Please Wait
Applying Filters...
menu
    • menu
    Granules India Limited has high volume world-class facilities for APIs, PFIs, & FDFs, serving customers in over 80 countries.

    Virtual Booth

    Contact Supplier

    Jai Radhe Sales is your partner for all your sourcing needs.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Egis is a Hungarian generic pharma company with 110 years history. Our activities incorporate all areas of the pharma value chain.

    Virtual Booth

    Contact Supplier

    Biophore is a research-driven global pharmaceutical company focused on niche APIs for the generic industry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    dihydroxy(stearoyloxy)aluminum

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 7047-84-9, Dibasic aluminum stearate, Dihydroxyaluminum stearate, Dihydroxy(stearato)aluminium, Dihydroxy(stearato)aluminum, Dihydroxyaluminium stearate, pure
    Molecular Formula
    C18H39AlO4
    Molecular Weight
    346.5  g/mol
    InChI Key
    OIPZNTLJVJGRCI-UHFFFAOYSA-M
    Aluminium monostearate is a salt of stearic acid and aluminium with the molecular formula Al(OH)2C18H35O2. Also known as dihydroxyaluminium or dihydroxy(stearato)aluminium, it is used to form gels in the packaging of pharmaceuticals and in the preparation of colors for cosmetics. While considered safe for use, extensive usage may result in aluminum accumulation.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 InChI
    InChI=1S/C18H36O2.Al.2H2O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20;;;/h2-17H2,1H3,(H,19,20);;2*1H2/q;+1;;/p-1
    2.1.2 InChI Key
    OIPZNTLJVJGRCI-UHFFFAOYSA-M
    2.1.3 Canonical SMILES
    CCCCCCCCCCCCCCCCCC(=O)O[Al].O.O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Aluminum Tristearate

    2. Ammonium Stearate

    3. Calcium Stearate

    4. Magnesium Stearate

    5. Octadecanoic Acid

    6. Sodium Stearate

    7. Stearic Acid

    8. Zinc Stearate

    2.2.2 Depositor-Supplied Synonyms

    1. 7047-84-9

    2. Dibasic Aluminum Stearate

    3. Dihydroxyaluminum Stearate

    4. Dihydroxy(stearato)aluminium

    5. Dihydroxy(stearato)aluminum

    6. Dihydroxyaluminium Stearate, Pure

    7. Chebi:31197

    8. Ncgc00160596-02

    9. Aluminum, Monostearate

    10. Aluminum, Dihydroxide Stearate

    11. Einecs 230-325-5

    12. Aluminum, Dihydroxy(stearato)-

    13. Aluminum Dihydroxide Stearate

    14. Unii-p9bc99461e

    15. Aluminum Dextran

    16. Aluminum Monostearate [jan:nf]

    17. Stearic Acid Aluminum Dihydroxide Salt

    18. Aluminum, Dihydroxy(octadecanoato-kappao)-

    19. Aluminum, Dihydroxy(octadecanoato-.kappa.o)-

    20. Schembl4101

    21. Dsstox_cid_28623

    22. Dsstox_rid_82893

    23. Dsstox_gsid_48697

    24. Chembl3185220

    25. Dtxsid9048697

    26. Dihydroxido(octadecanoato)aluminium

    27. Aluminum Monostearate (jp17/nf)

    28. Tox21_113090

    29. Akos024319334

    30. Db01375

    31. Ncgc00160596-01

    32. Ncgc00160596-03

    33. Cas-7047-84-9

    34. D01867

    35. F20724

    36. Sr-01000945248

    37. Q4119955

    38. Sr-01000945248-1

    39. Aluminum Monostearate, Technical, ~75% (al), Powder

    2.3 Create Date
    2007-08-23
    3 Chemical and Physical Properties
    Molecular Weight 346.5 g/mol
    Molecular Formula C18H39AlO4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count18
    Exact Mass346.2663731 g/mol
    Monoisotopic Mass346.2663731 g/mol
    Topological Polar Surface Area28.3 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity225
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 Mechanism of Action

    Antacids perform a neutralization reaction, ie. they buffer gastric acid, raising the pH to reduce acidity in the stomach. When gastric hydrochloric acid reaches the nerves in the gasitrointestinal mucosa, they signal pain to the central nervous system. This happens when these nerves are exposed, as in peptic ulcers. The gastric acid may also reach ulcers in the esophagus or the duodenum. Other mechanisms may contribute, such as the effect of aluminum ions inhibiting smooth muscle cell contraction and delaying gastric emptying. Aluminum is known to bind troponin C (a muscle protein) and to interfere with voltage-dependent calcium transport. Aluminum also binds to and inhibits the activity of mitochondrial voltage gated channels (VDAC).