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    Dimetindene

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

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    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: Dimetindene maleate, 3614-69-5, Forhistal maleate, Dimethpyrindene maleate, Fenistil-retard, Dimethinden maleate
    Molecular Formula
    C24H28N2O4
    Molecular Weight
    408.5  g/mol
    InChI Key
    SWECWXGUJQLXJF-BTJKTKAUSA-N
    FDA UNII
    6LL60J9E0O
    A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (Z)-but-2-enedioic acid;N,N-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1H-inden-2-yl]ethanamine
    2.1.2 InChI
    InChI=1S/C20H24N2.C4H4O4/c1-15(19-10-6-7-12-21-19)20-17(11-13-22(2)3)14-16-8-4-5-9-18(16)20;5-3(6)1-2-4(7)8/h4-10,12,15H,11,13-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
    2.1.3 InChI Key
    SWECWXGUJQLXJF-BTJKTKAUSA-N
    2.1.4 Canonical SMILES
    CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=CC(=O)O)C(=O)O
    2.1.5 Isomeric SMILES
    CC(C1=CC=CC=N1)C2=C(CC3=CC=CC=C32)CCN(C)C.C(=C\C(=O)O)\C(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    6LL60J9E0O
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dimethindene

    2. Dimethpyrindene

    3. Dimetindene

    4. Fenistil

    5. Forhistal

    6. Maleate, Dimethindene

    2.3.2 Depositor-Supplied Synonyms

    1. Dimetindene Maleate

    2. 3614-69-5

    3. Forhistal Maleate

    4. Dimethpyrindene Maleate

    5. Fenistil-retard

    6. Dimethinden Maleate

    7. Fenistil

    8. Su-6518

    9. Dimethindene Maleate [usan]

    10. Su 6518

    11. Dimethindene (maleate)

    12. Nsc-107677

    13. Mls002704010

    14. 6ll60j9e0o

    15. 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)pyridine Maleate (1:1)

    16. Triten

    17. (z)-but-2-enedioic Acid;n,n-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1h-inden-2-yl]ethanamine

    18. 1h-indene-2-ethanamine, N,n-dimethyl-3-(1-(2-pyridinyl)ethyl)-, (z)-2-butenedioate (1:1)

    19. Forthistal Maleate

    20. Dimethindene Malenate

    21. Dimetindene Maleate (jan)

    22. But-2-enedioic Acid;n,n-dimethyl-2-[3-(1-pyridin-2-ylethyl)-1h-inden-2-yl]ethanamine

    23. Dimethindene Maleate (usan)

    24. Dimetindene Hydrogen Maleate

    25. Dimetindene Maleate [jan]

    26. N,n-dimethyl-2-(3-(1-(pyridin-2-yl)ethyl)-1h-inden-2-yl)ethanamine Maleate

    27. Nsc107677

    28. Einecs 222-789-2

    29. Nsc 107677

    30. Unii-6ll60j9e0o

    31. Dimethindenmaleat

    32. 2-[1-[2-[2-(dimethylamino)ethyl]inden-3-yl]ethyl]pyridine Maleate (1:1)

    33. Dimethindene Maleate [usan:usp]

    34. Starbld0026265

    35. Forhistal Maleate (tn)

    36. 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)pyridine Maleate

    37. Schembl359490

    38. Chembl1870768

    39. Chebi:31500

    40. Dimethindene Maleate [mi]

    41. Dimetindene Maleate [mart.]

    42. Dimetindene Maleate [who-dd]

    43. Hy-13710a

    44. Mfcd00072146

    45. Pyridine, 2-(1-(2-(2-(dimethylamino)ethyl)inden-3-yl)ethyl)-, Maleate (1:1)

    46. Dimetindene Maleate [ep Monograph]

    47. Smr001570719

    48. Ws-01911

    49. Cs-0015467

    50. Z 820

    51. D01343

    52. F16365

    53. W-106641

    54. Q27265113

    55. 1h-indene-2-ethanamine,n-dimethyl-3-[1-(2-pyridinyl)ethyl]-, (z)-2-butenedioate (1:1)

    56. N,n-dimethyl-2-{3-[(rs)-1-(pyridine-2-yl)ethyl]-1h-inden-2-yl}ethanamin-(z)-butendioate

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 408.5 g/mol
    Molecular Formula C24H28N2O4
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count7
    Exact Mass408.20490738 g/mol
    Monoisotopic Mass408.20490738 g/mol
    Topological Polar Surface Area90.7 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity518
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipruritics

    Agents, usually topical, that relieve itching (pruritus). (See all compounds classified as Antipruritics.)

    Histamine H1 Antagonists

    Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

    Anti-Allergic Agents

    Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)