1. Lutalyse
2. Minprostin F2 Alpha
3. Pgf2alpha Tromethamine
4. Prostaglandin F2alpha Tromethamine
5. Prostin F2
6. Prostin F2 Alpha
1. 38562-01-5
2. Dinolytic
3. Zinoprost
4. Prostin F2 Alpha
5. Dinoprost Trometamol
6. Pgf2alpha Tham
7. Prostalmon F
8. Pgf2-alpha Tham
9. Prostaglandin F2alpha Tham
10. Panacelan F Tromethamine Salt
11. Prostaglandin F2-alpha Tham
12. Prostaglandin F2a Tromethamine
13. Pgf2a Tham
14. Dinoprost Tromethamine Salt
15. Enzaprost F Compd. With Trisamine
16. U-14,583e
17. Prostaglandin F(sub 2a) Tromethamine
18. Dinoprost (tromethamine Salt)
19. Lutalyse
20. (e,z)-(1r,2r,3r,5s)-7-(3,5-dihydroxy-2-((3s)-(3-hydroxy-1-octenyl))cyclopentyl)-5-heptenoic Acid Compound With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
21. Prostamate
22. Nsc-196515
23. Prostaglandin F2alpha Tris Salt
24. Pronalgon F
25. Ct6bbq5a68
26. U-14583e
27. Mls000028821
28. Chebi:31502
29. Dinoprost, Trometamol Salt
30. Tham Pgf2-alpha
31. Ensaprost
32. Smr000058792
33. U-14-583e
34. Lutalyse (veterinary)
35. Pgf2-alpha Tris Salt
36. Pgf2-alpha Tromethamine
37. Prostaglandin F2a Tris Salt
38. Pgf2-alpha Tromethamine Salt
39. Protaglandin F2-alpha-tham Salt
40. Prostaglandin F2-alpha Tham Salt
41. Prostaglandin F2-alpha Tromethamine
42. Tromethamine Prostaglandin F2-alpha
43. 2-amino-2-(hydroxymethyl)propane-1,3-diol (z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((s,e)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoate
44. Prostaglandin F2
45. A
46. Einecs 254-002-3
47. Prostin F2 Alpha (tn)
48. U 14585
49. Unii-ct6bbq5a68
50. Nsc 196515
51. Dinoprost Tromethamine (jan/usp)
52. Prostaglandin F2?
53. 5-heptenoic Acid, 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-, Tham
54. 7-(3,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl)-5-heptenoic Acid, Tromethamine Salt
55. Dinoprost Tromethamine [usan:usp:jan]
56. Pgf2.alpha. Tham
57. Pgf2alpha-tham
58. Prostaglandinf2atrissalt
59. Prostaglandin F2a Tham
60. Opera_id_1888
61. 7-[3, Tromethamine Salt
62. Dinoprost Tromethamine Powder
63. 1,3-propanediol, 2-amino-2-(hydroxymethyl)-, (5z,9alpha,11alpha,13e,15s)-9,11,15-trihydroxyprosta-5,13-dien-1-oate (salt)
64. Prosta-5,13-dien-1-oic Acid, (5z,9-alpha,11-alpha,13e,15s)-9,11,15-trihydroxy-, Compd. With Trimethylolaminomethane
65. Prosta-5,13-dien-1-oic Acid, 9,11,15-trihydroxy-, (5z,9alpha,11alpha,13e,15s)-, Compd. With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
66. Schembl203377
67. Prostaglandin F2.alpha. Tham
68. Chembl1200896
69. Dtxsid1045582
70. Regid_for_cid_5282415
71. Hms2230j05
72. Ex-a4115
73. Dinoprost Tromethamine [jan]
74. Dinoprost Trometamol [mart.]
75. Dinoprost Tromethamine [usan]
76. Hy-12956a
77. Nsc196515
78. S5056
79. Dinoprost Trometamol [who-dd]
80. Dinoprost Tromethamine [vandf]
81. Akos015920234
82. Ccg-269499
83. Db01160
84. Dinoprost Tromethamine [usp-rs]
85. Pgf2 Alpha (prostaglandin F2 Alpha )
86. Prostaglandin F2alpha Tromethamine Salt
87. Prostin F2 Alpha,3-propanediol (1:1)
88. Prosta-5,13-dien-1-oic Acid, 9,11,15-trihydroxy-, (5z,9.alpha.,11.alpha.,13e,15s)-, Compd. With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
89. Prostaglandin F2alpha (tromethamine Salt)
90. U-14
91. Dinoprost Trometamol [ep Monograph]
92. Dinoprost Tromethamine [green Book]
93. Dinoprost Tromethamine [orange Book]
94. B7617
95. Dinoprost Tromethamine [usp Monograph]
96. D01352
97. Prostaglandin F2.alpha.,3-propanediol (1:1)
98. Prostaglandin F2.alpha. Tromethamine Salt
99. 562d015
100. 562p015
101. Sr-01000946463
102. Sr-01000946463-1
103. Prostaglandin F2.alpha. Tromethamine Salt [mi]
104. Wln: L5tj Aq B2u4vq C1u1yq5 Dq &q1xz1q1q
105. Dinolytic; Pgf2-alpha Tham; Zinoprost; Prostin F2 Alpha
106. Prostaglandin F2alpha Tris Salt, >=99%, Synthetic, Powder
107. Prostaglandin F2alpha Tris Salt, Synthetic, Cell Culture Tested
108. Prostaglandin F2alpha Tromethamine Salt;dinoprost Tromethamine
109. Dinoprost Trometamol, European Pharmacopoeia (ep) Reference Standard
110. 5-heptenoic Acid,5-dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-, Tham
111. Dinoprost Compd. With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
112. Dinoprost Tromethamine, United States Pharmacopeia (usp) Reference Standard
113. 9?,11?,15s-trihydroxy-prosta-5z,13e-dien-1-oic Acid Tris(hydroxymethyl)aminomethane Salt
114. (e,2r,3r,5s)-7-[3,5-dihydroxy-2-[(3s)-(3-hydroxy-1-octenyl)]cyclopentyl]-5-heptenoic Acid Compound With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)@component Of Prostin F2 Alpha, Injectable
115. 2-amino-2-(hydroxymethyl)propane-1,3-diol(z)-7-((1r,2r,3r,5s)-3,5-dihydroxy-2-((s,e)-3-hydroxyoct-1-en-1-yl)cyclopentyl)hept-5-enoate
116. Prosta-5, (5z,9.alpha.,11.alpha.,13e,15s)-9,11,15-trihydroxy- Compd. With (trimethylolamino)methane
117. Prosta-5, 9,11,15-trihydroxy-, (5z,9.alpha.,11.alpha.,13e,15s)-, Compd. With 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
| Molecular Weight | 475.6 g/mol |
|---|---|
| Molecular Formula | C24H45NO8 |
| Hydrogen Bond Donor Count | 8 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 15 |
| Exact Mass | 475.31451739 g/mol |
| Monoisotopic Mass | 475.31451739 g/mol |
| Topological Polar Surface Area | 185 Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 486 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 5 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 2 |
Used for aborting second-trimester pregnancy (between the twelfth to eighteenth week of gestation) and in incomplete abortion or for therapeutic abortion in cases of intrauterine fetal death and congenital abnormalities incompatible with life. Also used at low-doses for medically indicated induction of labor at term. Also injected intra-arterially for use as a vasodilator to assist in angiography.
Dinoprost tromethamine is the tromethamine (THAM) salt of the naturally occurring prostaglandin F2alpha. Prostaglandin F2alpha has several pharmacologic effects on the female reproductive system, including stimulation of myometrial activity, relaxation of the cervix, inhibition of steroidogenesis by corpora lutea, and can potentially lyse corpora lutea.
Abortifacient Agents, Nonsteroidal
Non-steroidal chemical compounds with abortifacient activity. (See all compounds classified as Abortifacient Agents, Nonsteroidal.)
Oxytocics
Drugs that stimulate contraction of the myometrium. They are used to induce LABOR, OBSTETRIC at term, to prevent or control postpartum or postabortion hemorrhage, and to assess fetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (ABORTIFACIENTS). Oxytocics used clinically include the neurohypophyseal hormone OXYTOCIN and certain prostaglandins and ergot alkaloids. (From AMA Drug Evaluations, 1994, p1157) (See all compounds classified as Oxytocics.)
Absorption
Slowly absorbed from the amniotic fluid into systemic circulation.
Enzymatic dehydrogenation primarily in the maternal lungs and also in the liver.
The half-life of dinoprost in amniotic fluid is 3 to 6 hours. The plasma half-life of dinoprost after intravenous administration is reported to be less than 1 minute.
Dinoprost tromethamine appears to act directly on the myometrium, but this has not been completely established. Dinoprost stimulates myometrial contractions (via its interaction with the prostaglandin receptors) in the gravid uterus that are similar to the contractions that occur in the term uterus during labor. These contractions are usually sufficient to cause abortion. Uterine response to prostaglandins increases gradually throughout pregnancy. Dinoprost also facilitates cervical dilatation and softening.
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