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    Technical details about Diphosphonate, Technetium Methylene, learn more about the structure, uses, toxicity, action, side effects and more

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    Diphosphonate, Technetium Methylene

    DIGITAL CONTENT

    PharmaCompass

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    2D Structure
    1. Also known as: 8v3fgc4j77, Technetium tc-99m medronate anhydrous, Tc-99m-diphosphonate, Technetium diphosphonate, Tc-mdp, Tc-mdp tc-99m
    Molecular Formula
    CH2O6P2Tc
    Molecular Weight
    270.88  g/mol
    InChI Key
    DDVFLVSIVNKSLB-IEOVAKBOSA-J
    FDA UNII
    8V3FGC4J77
    Technetium Tc-99m Medronate is a radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with radioisotopic activity and hydroxyapatite affinity. Upon intravenous administration, skeletal uptake of technetium Tc 99m methylene diphosphonate occurs as a function of skeletal blood flow and osteogenic activity. The MDP moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization; labeling of MDP with Tc 99m allows scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    dioxido-oxo-(phosphonatomethyl)-5-phosphane;technetium-99(4+)
    2.1.2 InChI
    InChI=1S/CH6O6P2.Tc/c2-8(3,4)1-9(5,6)7;/h1H2,(H2,2,3,4)(H2,5,6,7);/q;+4/p-4/i;1+1
    2.1.3 InChI Key
    DDVFLVSIVNKSLB-IEOVAKBOSA-J
    2.1.4 Canonical SMILES
    C(P(=O)([O-])[O-])P(=O)([O-])[O-].[Tc+4]
    2.1.5 Isomeric SMILES
    C(P(=O)([O-])[O-])P(=O)([O-])[O-].[99Tc+4]
    2.2 Other Identifiers
    2.2.1 UNII
    8V3FGC4J77
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Tc-99m-diphosphonate

    2. Technetium Diphosphonate

    3. Technetium Tc 99m Diphosphonate

    2.3.2 Depositor-Supplied Synonyms

    1. 8v3fgc4j77

    2. Technetium Tc-99m Medronate Anhydrous

    3. Tc-99m-diphosphonate

    4. Technetium Diphosphonate

    5. Tc-mdp

    6. Tc-mdp Tc-99m

    7. Technetium Tc 99m Diphosphonate

    8. Technetium Tc-99m Diphosphonate

    9. Diphosphonic Acid, Technetium-99tc Salt

    10. Q27271059

    11. Dioxido-oxo-(phosphonatomethyl)-lambda5-phosphane;technetium-99(4+)

    12. Phosphonic Acid, Methylenebis-, Technetium(4+) Salt (1:1)

    13. Phosphonic Acid, Methylenebis-, Technetium(4+)-99tc Salt (1:1)

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 270.88 g/mol
    Molecular Formula CH2O6P2Tc
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count0
    Exact Mass270.838911 g/mol
    Monoisotopic Mass270.838911 g/mol
    Topological Polar Surface Area126 Ų
    Heavy Atom Count10
    Formal Charge0
    Complexity129
    Isotope Atom Count1
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Radiopharmaceuticals

    Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161) (See all compounds classified as Radiopharmaceuticals.)

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