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    Dirlotapide

    PATENTS & EXCLUSIVITIES

    PharmaCompass
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    2D Structure
    Also known as: Slentrol, 481658-94-0, Chembl410414, Cp-742,033, 578h0rmp25, Cp-742033
    Molecular Formula
    C40H33F3N4O3
    Molecular Weight
    674.7  g/mol
    InChI Key
    TUOSYWCFRFNJBS-BHVANESWSA-N
    FDA UNII
    578H0RMP25
    Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, Slentrol, and is not intended for human use.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    N-[(1S)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide
    2.1.2 InChI
    InChI=1S/C40H33F3N4O3/c1-46(25-26-11-5-3-6-12-26)39(50)36(28-13-7-4-8-14-28)45-38(49)35-24-29-23-31(21-22-34(29)47(35)2)44-37(48)33-16-10-9-15-32(33)27-17-19-30(20-18-27)40(41,42)43/h3-24,36H,25H2,1-2H3,(H,44,48)(H,45,49)/t36-/m0/s1
    2.1.3 InChI Key
    TUOSYWCFRFNJBS-BHVANESWSA-N
    2.1.4 Canonical SMILES
    CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)NC(C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
    2.1.5 Isomeric SMILES
    CN1C2=C(C=C(C=C2)NC(=O)C3=CC=CC=C3C4=CC=C(C=C4)C(F)(F)F)C=C1C(=O)N[C@@H](C5=CC=CC=C5)C(=O)N(C)CC6=CC=CC=C6
    2.2 Other Identifiers
    2.2.1 UNII
    578H0RMP25
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 5-((4'-trifluoromethyl-biphenyl-2-carbonyl)-amino)-1h-indole-2-carboxylic Acid Benzylmethyl Carbamoylamide

    2.3.2 Depositor-Supplied Synonyms

    1. Slentrol

    2. 481658-94-0

    3. Chembl410414

    4. Cp-742,033

    5. 578h0rmp25

    6. Cp-742033

    7. (s)-n-(2-(benzyl(methyl)amino)-2-oxo-1-phenylethyl)-1-methyl-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxamido)-1h-indole-2-carboxamide

    8. 1h-indole-2-carboxamide, 1-methyl-n-((1s)-2-(methyl(phenylmethyl)amino)-2-oxo-1-phenylethyl)-5-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-

    9. N-((1s)-2-(benzylmethylamino)-2-oxo-1-phenylethyl)-1-methyl-5-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)-1h-indole-2-carboxamide

    10. Dirlotapide [usan:inn]

    11. Unii-578h0rmp25

    12. Cp 742033

    13. Dirlotapide [mi]

    14. Dirlotapide [inn]

    15. Dirlotapide (usan/inn)

    16. Dirlotapide [usan]

    17. Schembl37781

    18. Slentrol [veterinary] (tn)

    19. Dirlotapide [green Book]

    20. Dtxsid00897432

    21. Bdbm50204367

    22. Hy-u00070

    23. Cs-6779

    24. Db11399

    25. Dirlotapide [ema Epar Veterinary]

    26. D03867

    27. Q5280905

    28. (s)-n-{2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl}-1-methyl-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxamido]-1h-indole-2-carboxamide

    29. 5-((4'-trifluoromethyl-biphenyl-2-carbonyl)-amino)-1h-indole-2-carboxylic Acid Benzylmethyl Carbamoylamide

    30. N-[(1s)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 674.7 g/mol
    Molecular Formula C40H33F3N4O3
    XLogP37.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count9
    Exact Mass674.25047541 g/mol
    Monoisotopic Mass674.25047541 g/mol
    Topological Polar Surface Area83.4 Ų
    Heavy Atom Count50
    Formal Charge0
    Complexity1150
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    As an aid in the management of overweight and obesity in adult dogs. To be used as part of an overall weight-management programme that also includes appropriate dietary changes and exercise practice.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    QA08AB91