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    Distigmine Bromide

    ACTIVE PHARMA INGREDIENTS

    MARKET PLACE

    PharmaCompass
    Xls

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    2D Structure
    Also known as: 15876-67-2, Ubretid, Ubritil, Distigmini bromidum, Hexamarium, Bromure de distigmine
    Molecular Formula
    C22H32Br2N4O4
    Molecular Weight
    576.3  g/mol
    InChI Key
    GJHSNEVFXQVOHR-UHFFFAOYSA-L
    FDA UNII
    750F36OP6J
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1-methylpyridin-1-ium-3-yl) N-methyl-N-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate;dibromide
    2.1.2 InChI
    InChI=1S/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2
    2.1.3 InChI Key
    GJHSNEVFXQVOHR-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C[N+]1=CC=CC(=C1)OC(=O)N(C)CCCCCCN(C)C(=O)OC2=C[N+](=CC=C2)C.[Br-].[Br-]
    2.2 Other Identifiers
    2.2.1 UNII
    750F36OP6J
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Distigmine

    2. Hexamarium

    3. Pyridinium, 3,3'-(1,6-hexanediylbis((methylimino)carbonyl)oxy)bis-1-methyl-, Dibromide

    4. Ubretid

    2.3.2 Depositor-Supplied Synonyms

    1. 15876-67-2

    2. Ubretid

    3. Ubritil

    4. Distigmini Bromidum

    5. Hexamarium

    6. Bromure De Distigmine

    7. Bromuro De Distigmina

    8. Distigminebromide

    9. Hexamarium Bromide

    10. Bc 51

    11. Distigmine Dibromide

    12. Bc-51

    13. 750f36op6j

    14. 3,3'-(1,6-hexanediylbis((methylimino)carbonyl)oxy)bis(1-methylpyridinium) Dibromide

    15. (1-methylpyridin-1-ium-3-yl) N-methyl-n-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate;dibromide

    16. 3,3'-(((hexane-1,6-diylbis(methylazanediyl))bis(carbonyl))bis(oxy))bis(1-methylpyridin-1-ium) Bromide

    17. 3-hydroxy-1-methylpyridinium Bromide Hexamethylenebis-(n-methylcarbamate)

    18. (1-methylpyridin-1-ium-3-yl) N-methyl-n-[6-[methyl-(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]hexyl]carbamate,dibromide

    19. 3,3'-{hexane-1,6-diylbis[(methylcarbamoyl)oxy]}bis(1-methylpyridin-1-ium) Dibromide

    20. Distigmini Bromidum [inn-latin]

    21. Distigmine Bromide [inn:ban:jan]

    22. Bromure De Distigmine [inn-french]

    23. Einecs 240-013-0

    24. Bromuro De Distigmina [inn-spanish]

    25. Adcostigmine

    26. Unii-750f36op6j

    27. Ubretid (tn)

    28. 3-hydroxy-1-methylpyridinium Bromide Hexamethylenebis(methylcarbamate)

    29. Schembl148842

    30. Distigmine Bromide [mi]

    31. Chembl1098285

    32. Distigmine Bromide [inn]

    33. Distigmine Bromide [jan]

    34. Chebi:31512

    35. Distigmine Bromide (jp17/inn)

    36. Dtxsid60935985

    37. Distigmine Bromide [mart.]

    38. Bcp16582

    39. Distigmine Bromide [who-dd]

    40. Mfcd00867188

    41. Akos015914117

    42. Pyridinium, 3-hydroxy-1-methyl-, Bromide, Hexamethylenebis(methylcarbamate)

    43. Ac-8868

    44. Pyridinium, 3,3'-(1,6-hexanediylbis((methylimino)carbonyl)oxy)bis-1-methyl-, Dibromide

    45. As-74357

    46. Sy226319

    47. Hy-119577

    48. Cs-0070000

    49. Ft-0718457

    50. C72992

    51. D01228

    52. A855351

    53. Q3277473

    54. 3,3'-(1,6-hexanediylbis((methylimino)carbonyl)oxy)bis(1-methylpyridinium)dibromide

    55. 3,3'-{hexane-1,6-diylbis[(methylcarbamoyl)oxy]}bis(1-methylpyridinium) Dibromide

    56. Hexamethylenebis(n-methylcarbaminoyl-1-methyl-3-hydroxypyridinium Bromide)

    57. 1-methyl-3-{[methyl({6-[methyl({[(1-methylpyridin-1-ium-3-yl)oxy]carbonyl})amino]hexyl})carbamoyl]oxy}pyridin-1-ium Dibromide

    58. 3,3-(((hexane-1,6-diylbis(methylazanediyl))bis(carbonyl))bis(oxy))bis(1-methylpyridin-1-ium) Bromide

    59. Pyridinium, 3,3'-(1,6-hexanediylbis((methylimino)carbonyl)oxy)bis(1-methyl-, Bromide (1:2)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 576.3 g/mol
    Molecular Formula C22H32Br2N4O4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count11
    Exact Mass576.07698 g/mol
    Monoisotopic Mass574.07903 g/mol
    Topological Polar Surface Area66.8 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity487
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Cholinesterase Inhibitors

    Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system. (See all compounds classified as Cholinesterase Inhibitors.)