1. Apo Domperidone
2. Apo-domperidone
3. Domidon
4. Domperidon
5. Domperidon Al
6. Domperidon Hexal
7. Domperidon Stada
8. Domperidon Teva
9. Domperidon-teva
10. Domperidona Gamir
11. Domperidone Maleate
12. Domperidone Maleate (1:1)
13. Domperidone Monohydrochloride
14. Gamir, Domperidona
15. Gastrocure
16. Hexal, Domperidon
17. Maleate, Domperidone
18. Monohydrochloride, Domperidone
19. Motilium
20. Nauzelin
21. Novo Domperidone
22. Novo-domperidone
23. Nu Domperidone
24. Nu-domperidone
25. Pridys
26. Pms Domperidone
27. Pms-domperidone
28. R-33,812
29. R-33812
30. R33,812
31. R33812
32. Ratio Domperidone
33. Ratio-domperidone
34. Stada, Domperidon
1. 57808-66-9
2. Motilium
3. Nauzelin
4. Domperidonum
5. Domperidona
6. C22h24cln5o2
7. R-33812
8. R 33,812
9. 4-(5-chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine
10. Nsc299589
11. Nsc-299589
12. 5-chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone
13. Domperidone (motilium)
14. R33812
15. Nsc-759575
16. Kw 5338
17. 6-chloro-3-[1-[3-(2-oxo-3h-benzimidazol-1-yl)propyl]piperidin-4-yl]-1h-benzimidazol-2-one
18. Mls000069343
19. Chembl219916
20. Chebi:31515
21. Nsc 299589
22. 2h-benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-
23. 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2h-benzimidazol-2-one
24. 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl]piperidin-4-yl}-1,3-dihydro-2h-benzimidazol-2-one
25. Motinorm
26. Costi
27. 5-chloro-1-[1-[3-(2-oxo-1-benzimidazolinyl)propyl]-4-piperidyl]-2-benzimidazolinone
28. Dsstox_cid_25116
29. Dsstox_rid_80682
30. Dsstox_gsid_45116
31. 1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)piperidin-1-yl)propyl)-1h-benzo[d]imidazol-2(3h)-one
32. 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one
33. 5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1h-benzo[d]imidazol-2(3h)-one
34. 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-1h-1,3-benzodiazol-1-yl)propyl]piperidin-4-yl}-2,3-dihydro-1h-1,3-benzodiazol-2-one
35. 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
36. Domperidonum [inn-latin]
37. Domperidona [inn-spanish]
38. 5587267z69
39. Motillium
40. Motilium (tn)
41. Smr000326802
42. Cas-57808-66-9
43. Kw-5338
44. Lopac-d-122
45. Sr-01000003002
46. Einecs 260-968-7
47. Brn 0903774
48. Nauzelin Od
49. Domperidone,(s)
50. 5-chloro-1-{1-[3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2h-benzimidazol-2-one
51. Domperidone [usan:inn:ban:jan]
52. Prestwick_794
53. Mfcd00069256
54. Nci299589
55. Unii-5587267z69
56. Hs-0067
57. Spectrum_000391
58. Opera_id_616
59. Specplus_000825
60. Domperidone [mi]
61. Prestwick0_000461
62. Prestwick1_000461
63. Prestwick2_000461
64. Prestwick3_000461
65. Spectrum4_000087
66. Domperidone [inn]
67. Domperidone [jan]
68. Domperidone [usan]
69. Biomol-nt_000022
70. Domperidone - Pharma Grade
71. Domperidone [vandf]
72. Ncistruc1_001686
73. Ncistruc2_001819
74. Domperidone [mart.]
75. Lopac0_000427
76. Schembl43729
77. Bspbio_002350
78. Domperidone [who-dd]
79. Gtpl965
80. Kbiogr_000354
81. Kbioss_000871
82. 5-24-02-00402 (beilstein Handbook Reference)
83. Mls000859942
84. Mls001306482
85. Mls002222324
86. Divk1c_006921
87. Spectrum2300212
88. Spbio_002501
89. Bpbio1_000620
90. Bpbio1_001185
91. Domperidone [green Book]
92. Dtxsid1045116
93. Domperidone (jp17/usan/inn)
94. Kbio1_001865
95. Kbio2_000871
96. Kbio2_003439
97. Kbio2_006007
98. Domperidone [ep Monograph]
99. Hms1922n04
100. Hms2089c14
101. Hms2093n22
102. Hms2096c21
103. Hms2230n18
104. Hms3261e16
105. Hms3269o13
106. Hms3370l03
107. Hms3413f15
108. Hms3656m21
109. Hms3677f15
110. Hms3713c21
111. Hms3884n19
112. Pharmakon1600-02300212
113. Bcp28265
114. Domperidone 1.0 Mg/ml In Methanol
115. Hy-b0411
116. Zinc4175569
117. Tox21_110056
118. Tox21_500427
119. Bbl028136
120. Bdbm50241107
121. Ccg-37870
122. Ncgc00014670
123. Nsc759575
124. S2461
125. Stk622843
126. Akos005555858
127. Tox21_110056_1
128. Ac-2037
129. Db01184
130. Domperidone, Powder, >=98% (hplc)
131. Lp00427
132. Nsc 759575
133. Sdccgsbi-0050412.p004
134. Ncgc00014670-01
135. Ncgc00014670-02
136. Ncgc00014670-03
137. Ncgc00014670-04
138. Ncgc00014670-05
139. Ncgc00014670-06
140. Ncgc00014670-07
141. Ncgc00014670-08
142. Ncgc00014670-09
143. Ncgc00014670-10
144. Ncgc00014670-11
145. Ncgc00014670-12
146. Ncgc00014670-13
147. Ncgc00014670-14
148. Ncgc00014670-16
149. Ncgc00014670-17
150. Ncgc00014670-28
151. Ncgc00015306-01
152. Ncgc00021472-02
153. Ncgc00021472-03
154. Ncgc00021472-04
155. Ncgc00021472-05
156. Ncgc00021472-06
157. Ncgc00021472-07
158. Ncgc00021472-08
159. Ncgc00097773-01
160. Ncgc00261112-01
161. 2h-benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl)-4-piperidinyl)-
162. 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1h-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-2h-benzimidazol-2-one
163. 5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1h-benzo[d]imidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2h-benzo[d]imidazol-2-one
164. Bd164379
165. Nci60_002512
166. Smr000058969
167. Ab00052423
168. D4125
169. Eu-0100427
170. Ft-0625588
171. Sw196931-3
172. C75710
173. D01745
174. Ab00052423-06
175. Ab00052423-07
176. Ab00052423_08
177. Ab00052423_09
178. 808d669
179. A831618
180. L000230
181. Q424238
182. R 33812
183. Sr-01000003002-2
184. Sr-01000003002-4
185. Sr-01000003002-7
186. W-105440
187. Brd-k38305202-001-02-6
188. Brd-k38305202-001-08-3
189. Domperidone, European Pharmacopoeia (ep) Reference Standard
190. 5-chloro-1-[1-[3-(2-oxo-1-benzimidazolyl)propyl]-4-piperidyl]benzimidazol-2-one
191. 1h-benzimidazol-2-ol, 5-chloro-1-[1-[3-(2-hydroxy-1h-benzimidazol-1-yl)propyl]-4-piperidinyl]-
192. 2h-benzimidazol-2-one,3-dihydro-2-oxo-1h-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-
193. 5-chloro-1-[1-[3-(2,3-dihydro-2-oxo -1h-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-d Ihydro-2h-benzimidazol-2-one
194. 5-chloro-1-{1-[3-(1,3-dihydro-2-oxo-2h-benzimidazol-1-yl)propyl]-4-piperidinyl}-1,3-dihydro-2h-benzimidazol-2-one
195. 5-chloro-1-{1-[3-(2-hydroxy-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-2,3-dihydro-1h-benzoimidazol-2-ol
196. 5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one(domperidone)
197. 6-chloro-3-[1-[3-(2-oxo-3a,7a-dihydro-3h-benzimidazol-1-yl)propyl]-4-piperidyl]-3a,7a-dihydro-1h-benzimidazol-2-one
198. Domperidone5-chloro-1-{1-[3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one
| Molecular Weight | 425.9 g/mol |
|---|---|
| Molecular Formula | C22H24ClN5O2 |
| XLogP3 | 3.9 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 5 |
| Exact Mass | 425.1618527 g/mol |
| Monoisotopic Mass | 425.1618527 g/mol |
| Topological Polar Surface Area | 67.9 Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 655 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
Domperidone is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Antiemetics
Drugs used to prevent NAUSEA or VOMITING. (See all compounds classified as Antiemetics.)
Dopamine Antagonists
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)
A03FA03
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
A - Alimentary tract and metabolism
A03 - Drugs for functional gastrointestinal disorders
A03F - Propulsives
A03FA - Propulsives
A03FA03 - Domperidone
Domperidone has known human metabolites that include 1-Propyl-1,3-dihydro-2H-benzimidazol-2-one, 3-[3-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]propyl]-6-hydroxy-1H-benzimidazol-2-one, and 5-Chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
7 hours
Domperidone acts as a gastrointestinal emptying (delayed) adjunct and peristaltic stimulant. The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Domperidone facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates nausea and vomiting
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