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    Dotinurad

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    2D Structure
    Also known as: 1285572-51-1, Fyu-981, Dotinurad [inn], (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2h)-yl)methanone, 305eb53128, (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2h-1,3-benzothiazol-3-yl)methanone
    Molecular Formula
    C14H9Cl2NO4S
    Molecular Weight
    358.2  g/mol
    InChI Key
    VOFLAIHEELWYGO-UHFFFAOYSA-N
    FDA UNII
    305EB53128
    Dotinurad is under investigation in clinical trial NCT03372200 (Febuxostat-controlled, Double-blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2H-1,3-benzothiazol-3-yl)methanone
    2.1.2 InChI
    InChI=1S/C14H9Cl2NO4S/c15-9-5-8(6-10(16)13(9)18)14(19)17-7-22(20,21)12-4-2-1-3-11(12)17/h1-6,18H,7H2
    2.1.3 InChI Key
    VOFLAIHEELWYGO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1N(C2=CC=CC=C2S1(=O)=O)C(=O)C3=CC(=C(C(=C3)Cl)O)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    305EB53128
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2h-1,3-benzothiazol-3-yl)methanone

    2. Fyu-981

    2.3.2 Depositor-Supplied Synonyms

    1. 1285572-51-1

    2. Fyu-981

    3. Dotinurad [inn]

    4. (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2h)-yl)methanone

    5. 305eb53128

    6. (3,5-dichloro-4-hydroxyphenyl)-(1,1-dioxo-2h-1,3-benzothiazol-3-yl)methanone

    7. Urece

    8. Methanone, (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxido-3(2h)-benzothiazolyl)-

    9. Urece (tn)

    10. Dotinurad (jan/inn)

    11. Dotinurad [jan]

    12. Dotinurad [who-dd]

    13. Fyu981

    14. Chembl4594446

    15. Schembl10322525

    16. Gtpl11389

    17. Unii-305eb53128

    18. Ex-a5737

    19. Bdbm50561689

    20. Hy-109031

    21. Cs-0030545

    22. D11071

    23. 3-(3,5-dichloro-4-hydroxybenzoyl)-1,1-dioxo-2,3-dihydro-1,3-benzothiazole

    2.4 Create Date
    2011-05-09
    3 Chemical and Physical Properties
    Molecular Weight 358.2 g/mol
    Molecular Formula C14H9Cl2NO4S
    XLogP32.9
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count1
    Exact Mass356.9629343 g/mol
    Monoisotopic Mass356.9629343 g/mol
    Topological Polar Surface Area83.1 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity538
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Uricosuric Agents

    Gout suppressants that act directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. (See all compounds classified as Uricosuric Agents.)