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2D Structure
Also known as: 1262132-81-9, Jtz-951, Jtz 951, Enarodustat [inn], Jsk7tua223, 2-[[7-oxo-5-(2-phenylethyl)-3h-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino]acetic acid
Molecular Formula
C17H16N4O4
Molecular Weight
340.33  g/mol
InChI Key
FJYRBJKWDXVHHO-UHFFFAOYSA-N
FDA UNII
JSK7TUA223

Enarodustat is under investigation in clinical trial NCT02581124 (Study to Evaluate Effect of Lapatinib on Pharmacokinetics of JTZ-951 in Subjects With End-stage Renal Disease).
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
2-[[7-oxo-5-(2-phenylethyl)-3H-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino]acetic acid
2.1.2 InChI
InChI=1S/C17H16N4O4/c22-13-8-12(7-6-11-4-2-1-3-5-11)21-16(19-10-20-21)15(13)17(25)18-9-14(23)24/h1-5,8,10H,6-7,9H2,(H,18,25)(H,19,20)(H,23,24)
2.1.3 InChI Key
FJYRBJKWDXVHHO-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1=CC=C(C=C1)CCC2=CC(=O)C(=C3N2NC=N3)C(=O)NCC(=O)O
2.2 Other Identifiers
2.2.1 UNII
JSK7TUA223
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Glycine, N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)-

2. Jtz-951

3. N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)glycine

2.3.2 Depositor-Supplied Synonyms

1. 1262132-81-9

2. Jtz-951

3. Jtz 951

4. Enarodustat [inn]

5. Jsk7tua223

6. 2-[[7-oxo-5-(2-phenylethyl)-3h-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino]acetic Acid

7. Enarodustat (jan)

8. Enarodustat [jan]

9. (7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine

10. 2-(7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carboxamido)acetic Acid

11. Glycine, N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)-

12. Enaroy

13. Enarodustat (jtz-951)

14. Unii-jsk7tua223

15. Enarodustat [who-dd]

16. Jtz951

17. Schembl1481440

18. Chembl4297619

19. Gtpl11828

20. Jtz-951jtz-951

21. C17h16n4o4

22. Dtxsid901336902

23. Ex-a4798

24. S9656

25. Akos040741697

26. Db14985

27. Compound 14 [pmid: 29259755]

28. Ac-36543

29. Bj162590

30. Ms-25187

31. Hy-109057

32. Cs-0031647

33. D11523

34. N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)glycine

35. 1494680-11-3

36. 2-{[7-oxo-5-(2-phenylethyl)-3h,7h-[1,2,4]triazolo[1,5-a]pyridin-8-yl]formamido}acetic Acid

2.4 Create Date
2011-02-28
3 Chemical and Physical Properties
Molecular Weight 340.33 g/mol
Molecular Formula C17H16N4O4
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass g/mol
Monoisotopic Mass g/mol
Topological Polar Surface Area111
Heavy Atom Count25
Formal Charge0
Complexity674
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1