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    Enarodustat

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 1262132-81-9, Jtz-951, Jtz 951, Enarodustat [inn], Jsk7tua223, 2-[[7-oxo-5-(2-phenylethyl)-3h-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino]acetic acid
    Molecular Formula
    C17H16N4O4
    Molecular Weight
    340.33  g/mol
    InChI Key
    FJYRBJKWDXVHHO-UHFFFAOYSA-N
    FDA UNII
    JSK7TUA223
    Enarodustat is under investigation in clinical trial NCT02581124 (Study to Evaluate Effect of Lapatinib on Pharmacokinetics of JTZ-951 in Subjects With End-stage Renal Disease).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[[7-oxo-5-(2-phenylethyl)-3H-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino]acetic acid
    2.1.2 InChI
    InChI=1S/C17H16N4O4/c22-13-8-12(7-6-11-4-2-1-3-5-11)21-16(19-10-20-21)15(13)17(25)18-9-14(23)24/h1-5,8,10H,6-7,9H2,(H,18,25)(H,19,20)(H,23,24)
    2.1.3 InChI Key
    FJYRBJKWDXVHHO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)CCC2=CC(=O)C(=C3N2NC=N3)C(=O)NCC(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    JSK7TUA223
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Glycine, N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)-

    2. Jtz-951

    3. N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)glycine

    2.3.2 Depositor-Supplied Synonyms

    1. 1262132-81-9

    2. Jtz-951

    3. Jtz 951

    4. Enarodustat [inn]

    5. Jsk7tua223

    6. 2-[[7-oxo-5-(2-phenylethyl)-3h-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl]amino]acetic Acid

    7. Enarodustat (jan)

    8. Enarodustat [jan]

    9. (7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carbonyl)glycine

    10. 2-(7-hydroxy-5-phenethyl-[1,2,4]triazolo[1,5-a]pyridine-8-carboxamido)acetic Acid

    11. Glycine, N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)-

    12. Enaroy

    13. Enarodustat (jtz-951)

    14. Unii-jsk7tua223

    15. Enarodustat [who-dd]

    16. Jtz951

    17. Schembl1481440

    18. Chembl4297619

    19. Gtpl11828

    20. Jtz-951jtz-951

    21. C17h16n4o4

    22. Dtxsid901336902

    23. Ex-a4798

    24. S9656

    25. Akos040741697

    26. Db14985

    27. Compound 14 [pmid: 29259755]

    28. Ac-36543

    29. Bj162590

    30. Ms-25187

    31. Hy-109057

    32. Cs-0031647

    33. D11523

    34. N-((7-hydroxy-5-(2-phenylethyl)(1,2,4)triazolo(1,5-a)pyridin-8-yl)carbonyl)glycine

    35. 1494680-11-3

    36. 2-{[7-oxo-5-(2-phenylethyl)-3h,7h-[1,2,4]triazolo[1,5-a]pyridin-8-yl]formamido}acetic Acid

    2.4 Create Date
    2011-02-28
    3 Chemical and Physical Properties
    Molecular Weight 340.33 g/mol
    Molecular Formula C17H16N4O4
    XLogP31.6
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass g/mol
    Monoisotopic Mass g/mol
    Topological Polar Surface Area111
    Heavy Atom Count25
    Formal Charge0
    Complexity674
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1