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    ENB003

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    PharmaCompass
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    2D Structure
    Also known as: Bq-788, di(methyl-d)-, 2364572-10-9, D-norleucine, n-((cis-2,6-di(methyl-d)-1-piperidinyl)carbonyl)-4-methyl-l-leucyl-1-(methoxycarbonyl)-d-tryptophyl-, sodium salt, Unii-aay8r26vdx, Enb003, Enb-003 [who-dd]
    Molecular Formula
    C34H50N5NaO7
    Molecular Weight
    665.8  g/mol
    InChI Key
    QCVIFBRTTLMEOV-ZOHSNMQTSA-M
    FDA UNII
    AAY8R26VDX
    Endothelin B Receptor Blocker ENB 003 is an antagonist of the immune checkpoint endothelin B receptor (ETBR; EDNRB), with potential immunomodulating and antineoplastic activities. Upon administration, the ETBR blocker ENB 003 selectively targets and binds to ETBR expressed on tumor cells. This prevents ETBR-mediated signaling and may abrogate the immunosuppressive tumor microenvironment (TME), may enhance a T-cell mediated anti-tumor immune response and may inhibit proliferation of ETBR-expressing tumor cells. ETBR, a G-protein coupled receptor, is overexpressed in a variety of tumor cell types and plays a key role in tumor cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and angiogenesis. It also plays a role in tumor immunosuppression and blocks T-cell trafficking.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;(2R)-2-[[(2R)-2-[[(2S)-2-[[(2R,6S)-2,6-bis(deuteriomethyl)piperidine-1-carbonyl]amino]-4,4-dimethylpentanoyl]amino]-3-(1-methoxycarbonylindol-3-yl)propanoyl]amino]hexanoate
    2.1.2 InChI
    InChI=1S/C34H51N5O7.Na/c1-8-9-16-25(31(42)43)35-29(40)26(18-23-20-38(33(45)46-7)28-17-11-10-15-24(23)28)36-30(41)27(19-34(4,5)6)37-32(44)39-21(2)13-12-14-22(39)3;/h10-11,15,17,20-22,25-27H,8-9,12-14,16,18-19H2,1-7H3,(H,35,40)(H,36,41)(H,37,44)(H,42,43);/q;+1/p-1/t21-,22+,25-,26-,27+;/m1./s1/i2D,3D;
    2.1.3 InChI Key
    QCVIFBRTTLMEOV-ZOHSNMQTSA-M
    2.1.4 Canonical SMILES
    CCCCC(C(=O)[O-])NC(=O)C(CC1=CN(C2=CC=CC=C21)C(=O)OC)NC(=O)C(CC(C)(C)C)NC(=O)N3C(CCCC3C)C.[Na+]
    2.1.5 Isomeric SMILES
    [2H]C[C@H]1CCC[C@H](N1C(=O)N[C@@H](CC(C)(C)C)C(=O)N[C@H](CC2=CN(C3=CC=CC=C32)C(=O)OC)C(=O)N[C@H](CCCC)C(=O)[O-])C[2H].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    AAY8R26VDX
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. Bq-788, Di(methyl-d)-

    2. 2364572-10-9

    3. D-norleucine, N-((cis-2,6-di(methyl-d)-1-piperidinyl)carbonyl)-4-methyl-l-leucyl-1-(methoxycarbonyl)-d-tryptophyl-, Sodium Salt

    4. Unii-aay8r26vdx

    5. Enb003

    6. Enb-003 [who-dd]

    7. Enb-003

    2.4 Create Date
    2020-01-23
    3 Chemical and Physical Properties
    Molecular Weight 665.8 g/mol
    Molecular Formula C34H50N5NaO7
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count14
    Exact Mass665.37334672 g/mol
    Monoisotopic Mass665.37334672 g/mol
    Topological Polar Surface Area162 Ų
    Heavy Atom Count47
    Formal Charge0
    Complexity1080
    Isotope Atom Count2
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2