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    Ephedrine Sulfate

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    2D Structure
    Also known as: Ephedrine sulphate, Isofedrol, Akovaz, 134-72-5, Corphedra, Ephedrine sulfate [usp]
    Molecular Formula
    C20H32N2O6S
    Molecular Weight
    428.5  g/mol
    InChI Key
    CAVQBDOACNULDN-KHFUBBAMSA-N
    FDA UNII
    U6X61U5ZEG
    A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1R,2S)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric acid
    2.1.2 InChI
    InChI=1S/2C10H15NO.H2O4S/c2*1-8(11-2)10(12)9-6-4-3-5-7-9;1-5(2,3)4/h2*3-8,10-12H,1-2H3;(H2,1,2,3,4)/t2*8-,10-;/m00./s1
    2.1.3 InChI Key
    CAVQBDOACNULDN-KHFUBBAMSA-N
    2.1.4 Canonical SMILES
    CC(C(C1=CC=CC=C1)O)NC.CC(C(C1=CC=CC=C1)O)NC.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.C[C@@H]([C@@H](C1=CC=CC=C1)O)NC.OS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    U6X61U5ZEG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ephedrine

    2. Ephedrine Erythro Isomer

    3. Ephedrine Hydrochloride

    4. Ephedrine Renaudin

    5. Erythro Isomer Of Ephedrine

    6. Hydrochloride, Ephedrine

    7. Renaudin, Ephedrine

    8. Sal Phedrine

    9. Sal-phedrine

    10. Salphedrine

    11. Sulfate, Ephedrine

    2.3.2 Depositor-Supplied Synonyms

    1. Ephedrine Sulphate

    2. Isofedrol

    3. Akovaz

    4. 134-72-5

    5. Corphedra

    6. Ephedrine Sulfate [usp]

    7. U6x61u5zeg

    8. (-)-ephedrine Sulfate (2:1) (salt)

    9. 134-72-5 (sulfate)

    10. (-)-ephedrine Hemisulfate

    11. Nci-c55652

    12. Ephedrine Sulfate (usp)

    13. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alphar)-, Sulfate (2:1) (salt)

    14. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol;sulfuric Acid

    15. L-ephedrine Sulfate

    16. Unii-u6x61u5zeg

    17. Expansyl

    18. Ccris 1351

    19. Ephedrini Sulfas

    20. Pazo Ointment

    21. Franol Plus

    22. Franol-plus

    23. (1r,2s)-2-(methylamino)-1-phenylpropan-1-ol Sulfate (2:1) (salt)

    24. Pazo Suppositories

    25. Corphedra (tn)

    26. Emerphed (tn)

    27. Einecs 205-154-4

    28. Akovaz (tn)

    29. Emerphed

    30. Ephedrine L- Sulfate

    31. 1-phenyl-2-methylamine-propanol-1-sulfate

    32. Ec 205-154-4

    33. Schembl41262

    34. (1r,2s)-1-phenyl-2-methylaminopropanol-1 Sulfate

    35. Ephedrine Sulfate [mi]

    36. 1-alpha-(1-(methylamino)ethyl)benzyl Alcohol Sulfate

    37. Chembl1523964

    38. Dtxsid6020565

    39. Ephedrine Sulfate [vandf]

    40. Ephedrine Sulfate [mart.]

    41. Ephedrine Sulfate [usp-rs]

    42. Ephedrine Sulfate [who-dd]

    43. Ephedrine Sulfate [who-ip]

    44. (-)-erythro-1-hydroxy-2-(methylamino)-1-phenylpropane Sulfate

    45. Bdbm50480314

    46. Akos015901652

    47. Ephedrine Sulfate [orange Book]

    48. Ephedrini Sulfas [who-ip Latin]

    49. Ephedrine Sulfate [usp Monograph]

    50. Ncgc00093901-01

    51. Ephedrine Sulfate (2:1) (salt), (-)-

    52. Eu-0100501

    53. D04018

    54. E 3250

    55. Q27290771

    56. Ephedrine Sulphate 1.0 Mg/ml In Methanol (as Free Base)

    57. Bis((r-(r*,s*))-beta-hydroxy-alpha-methylphenethyl)methylammonium Sulphate

    58. Bis((r-(r*,s*))-beta-hydroxy-alpha-methylphenethyl)methylammonium) Sulphate

    59. Benzenemethanol, Alpha-((1s)-1-(methylamino)ethyl)-, (alphar)-, Sulfate (2:1)

    60. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (r-(r*,s*))-, Sulfate (2:1) (salt)

    61. Benzenemethanol, Alpha-(1-(methylamino)ethyl)-, (theta-(theta,s))-, Sulfate (2:1) (salt)

    62. (r-(r*,s*))-.alpha.-(1-(methylamino)ethyl)benzenemethanol Sulfate (2:1) (salt) [who-ip]

    63. Benzenemethanol, .alpha.-(1-(methylamino)ethyl)-, (r-(r*,s*))-, Sulfate (2:1) (salt)

    2.4 Create Date
    2005-07-19
    3 Chemical and Physical Properties
    Molecular Weight 428.5 g/mol
    Molecular Formula C20H32N2O6S
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count6
    Exact Mass428.19810792 g/mol
    Monoisotopic Mass428.19810792 g/mol
    Topological Polar Surface Area148 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity202
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Adrenergic Agents

    Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)

    Sympathomimetics

    Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. (See all compounds classified as Sympathomimetics.)

    Vasoconstrictor Agents

    Drugs used to cause constriction of the blood vessels. (See all compounds classified as Vasoconstrictor Agents.)

    Central Nervous System Stimulants

    A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here. (See all compounds classified as Central Nervous System Stimulants.)

    4.2 FDA Pharmacological Classification
    4.2.1 Pharmacological Classes
    Adrenergic beta-Agonists [MoA]; Increased Norepinephrine Activity [PE]; Norepinephrine Releasing Agent [EPC]; alpha-Adrenergic Agonist [EPC]; beta-Adrenergic Agonist [EPC]; Adrenergic alpha-Agonists [MoA]