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    Eprosartan Mesylate

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 144143-96-4, Teveten, Eprosartan mesilate, Eprosartan methanesulfonate, Eprosartan monomethanesulfonate, Eprosartan (mesylate)
    Molecular Formula
    C24H28N2O7S2
    Molecular Weight
    520.6  g/mol
    InChI Key
    DJSLTDBPKHORNY-XMMWENQYSA-N
    FDA UNII
    8N2L1NX8S3
    Eprosartan Mesylate is the mesylate salt form of eprosartan, a non-biphenyl, non-tetrazole, nonpeptide angiotensin II antagonist with antihypertensive activity. Eprosartan mesylate antagonizes angiotensin II type I receptors in tissues such as vascular smooth muscle and the adrenal gland. This prevents angiotensin II-induced vasoconstriction and prevents angiotensin II-mediated stimulation of aldosterone secretion by the adrenal cortex, which decreases the excretion of sodium and water and increases the excretion of potassium.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-[[2-butyl-5-[(E)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic acid;methanesulfonic acid
    2.1.2 InChI
    InChI=1S/C23H24N2O4S.CH4O3S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27;1-5(2,3)4/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29);1H3,(H,2,3,4)/b18-12+;
    2.1.3 InChI Key
    DJSLTDBPKHORNY-XMMWENQYSA-N
    2.1.4 Canonical SMILES
    CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)C=C(CC3=CC=CS3)C(=O)O.CS(=O)(=O)O
    2.1.5 Isomeric SMILES
    CCCCC1=NC=C(N1CC2=CC=C(C=C2)C(=O)O)/C=C(\CC3=CC=CS3)/C(=O)O.CS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    8N2L1NX8S3
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 2-thiophenepropanoic Acid, Alpha-((2-butyl-1-((4- Carboxyphenyl)methyl)-lh-imidazol-5-yl)methylene)-, (e)-

    2. Eprosartan

    3. Sk And F 108566

    4. Skf-108566

    5. Teveten

    2.3.2 Depositor-Supplied Synonyms

    1. 144143-96-4

    2. Teveten

    3. Eprosartan Mesilate

    4. Eprosartan Methanesulfonate

    5. Eprosartan Monomethanesulfonate

    6. Eprosartan (mesylate)

    7. Sk&f 108566-j

    8. Sk&f-108566-j

    9. 8n2l1nx8s3

    10. Chebi:48409

    11. (e)-2-butyl-1-(p-carboxybenzyl)-alpha-2-thenylimidazole-5-acrylic Acid, Monomethanesulfonate

    12. 4-[[2-butyl-5-[(e)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic Acid;methanesulfonic Acid

    13. Eprosartan Mesylate (usan)

    14. Dsstox_cid_24217

    15. Dsstox_rid_80124

    16. Dsstox_gsid_44217

    17. Eprosartan Mesylate [usan]

    18. 4-({2-butyl-5-[(1e)-2-carboxy-2-(thiophen-2-ylmethyl)eth-1-en-1-yl]-1h-imidazol-1-yl}methyl)benzoic Acid; Methanesulfonic Acid

    19. Cas-144143-96-4

    20. Eprosartan Mesylate [usan:ban]

    21. Ncgc00164557-01

    22. Unii-8n2l1nx8s3

    23. Futuran

    24. Navixen

    25. Regulaten

    26. Tevetenz

    27. Epro-sartan Mesylate Dihydrate

    28. Sr-05000001450

    29. Eprosartanmesylate

    30. Teveten Sb

    31. Skf-108566j

    32. Teveten (tn)

    33. Schembl41396

    34. Chembl1200987

    35. Dtxsid7044217

    36. Hms3262b17

    37. Hms3885b05

    38. Eprosartan Mesylate [vandf]

    39. Eprosartan Mesilate [mart.]

    40. Tox21_112186

    41. Tox21_500808

    42. Eprosartan Mesilate [who-dd]

    43. Eprosartan Mesylate [usp-rs]

    44. Hy-15834a

    45. Mfcd08141807

    46. S4102

    47. Akos015994738

    48. Eprosartan Mesylate, >=98% (hplc)

    49. Tox21_112186_1

    50. Am84399

    51. Ccg-222112

    52. Ks-1233

    53. Eprosartan Mesylate [orange Book]

    54. Ncgc00167505-02

    55. Ncgc00261493-01

    56. (e)-4-((2-butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1h-imidazol-1-yl)methyl)benzoic Acid Compound With Methanesulfonic Acid (1:1)

    57. 2-thiophenepropanoic Acid, Alpha-((2-butyl-1-((4-carboxyphenyl)methyl)-1h-imidazol-5-yl)methylene)-, (e)-, Monomethanesulfonate

    58. Eprosartan Mesylate [usp Monograph]

    59. Eprosartan Monomethanesulfonate [mi]

    60. E-145

    61. E1161

    62. Sw219286-1

    63. A13747

    64. D02082

    65. Teveten Hct Component Eprosartan Mesylate

    66. 143e964

    67. A808180

    68. Eprosartan Mesylate Component Of Teveten Hct

    69. J-007923

    70. Sr-05000001450-2

    71. Q27121190

    72. Eprosartan Mesylate, United States Pharmacopeia (usp) Reference Standard

    73. (e)-2-butyl-1-(p-carboxybenzyl)-.alpha.-2-thenylimidazole-5-acrylic Acid, Monomethanesulfonate

    74. (e)-2-butyl-1-(p-carboxybenzyl)-.alpha.-2-thenylimidazole-5-acrylic Acid, Monomethanesulphonate

    75. (e)-4-((2-butyl-5-(2-carboxy-3-(thiophen-2-yl)prop-1-en-1-yl)-1h-imidazol-1-yl)methyl)benzoic Acid Methanesulfonic Acid Salt

    76. (e)-alpha-((2-butyl-1-((4-carboxyphenyl)methyl)-1h-imidazol-5-yl)methylene)-2-thiophenepropanoic Acid Monomethanesulfonate

    77. 2-thiophenepropanoic Acid, .alpha.-((2-butyl-1-((4-carboxyphenyl)methyl)-1h-imidazol-5-yl)methylene)-, (e)-, Monomethanesulfonate

    78. 2-thiophenepropanoic Acid, .alpha.-((2-butyl-1-((4-carboxyphenyl)methyl)-1h-imidazol-5-yl)methylene)-, (e)-, Monomethanesulphonate

    79. 2-thiophenepropanoic Acid, Alpha-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1h-imidazol-5-yl]methylene]-, (alphae)-, Methanesulfonate (1:1)

    80. 4-({2-butyl-5-[(1e)-2-carboxy-3-(2-thienyl)prop-1-en-1-yl]-1h-imidazol-1-yl}methyl)benzoic Acid Methanesulfonate

    81. 4-[[2-butyl-5-[(e)-2-carboxy-3-(2-thienyl)prop-1-enyl]imidazol-1-yl]methyl]benzoic Acid; Methanesulfonic Acid

    82. 4-[[2-butyl-5-[(e)-2-carboxy-3-thiophen-2-ylprop-1-enyl]imidazol-1-yl]methyl]benzoic Acid;methanesulfonic Acid.

    83. Eprosartan Mesylate

    84. Sk&f 108566

    85. (?e)-?-[[2-butyl-1-[(4-carboxyphenyl)methyl]-1h-imidazol-5-yl]methylene]-2-thiophenepropanoic Acid Methanesulfonate

    2.4 Create Date
    2005-10-11
    3 Chemical and Physical Properties
    Molecular Weight 520.6 g/mol
    Molecular Formula C24H28N2O7S2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count10
    Exact Mass520.13379358 g/mol
    Monoisotopic Mass520.13379358 g/mol
    Topological Polar Surface Area183 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity711
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameEprosartan mesylate
    PubMed HealthEprosartan (By mouth)
    Drug ClassesCardiovascular Agent, Renal Protective Agent
    Drug LabelTEVETEN (eprosartan mesylate) is a non-biphenyl non-tetrazole angiotensin II receptor (AT1) antagonist. A selective non-peptide molecule, TEVETEN is chemically described as the monomethanesulfonate of (E )-2-butyl-1-(p-carboxybenzyl)--2-thienyl...
    Active IngredientEprosartan mesylate
    Dosage FormTablet
    RouteOral
    Strengtheq 600mg base; eq 400mg base
    Market StatusPrescription
    CompanyMylan Pharms

    2 of 4  
    Drug NameTeveten
    Drug LabelTEVETEN (eprosartan mesylate) is a non-biphenyl non-tetrazole angiotensin II receptor (AT1) antagonist. A selective non-peptide molecule, TEVETEN is chemically described as the monomethanesulfonate of (E )-2-butyl-1-(p-carboxybenzyl)--2-thienyl...
    Active IngredientEprosartan mesylate
    Dosage FormTablet
    RouteOral
    Strengtheq 600mg base; eq 400mg base
    Market StatusPrescription
    CompanyAbbvie

    3 of 4  
    Drug NameEprosartan mesylate
    PubMed HealthEprosartan (By mouth)
    Drug ClassesCardiovascular Agent, Renal Protective Agent
    Drug LabelTEVETEN (eprosartan mesylate) is a non-biphenyl non-tetrazole angiotensin II receptor (AT1) antagonist. A selective non-peptide molecule, TEVETEN is chemically described as the monomethanesulfonate of (E )-2-butyl-1-(p-carboxybenzyl)--2-thienyl...
    Active IngredientEprosartan mesylate
    Dosage FormTablet
    RouteOral
    Strengtheq 600mg base; eq 400mg base
    Market StatusPrescription
    CompanyMylan Pharms

    4 of 4  
    Drug NameTeveten
    Drug LabelTEVETEN (eprosartan mesylate) is a non-biphenyl non-tetrazole angiotensin II receptor (AT1) antagonist. A selective non-peptide molecule, TEVETEN is chemically described as the monomethanesulfonate of (E )-2-butyl-1-(p-carboxybenzyl)--2-thienyl...
    Active IngredientEprosartan mesylate
    Dosage FormTablet
    RouteOral
    Strengtheq 600mg base; eq 400mg base
    Market StatusPrescription
    CompanyAbbvie

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Angiotensin II Type 2 Receptor Blockers

    Agents that antagonize the ANGIOTENSIN II TYPE 2 RECEPTOR. (See all compounds classified as Angiotensin II Type 2 Receptor Blockers.)