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    Estropipate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: 7280-37-7, Piperazine estrone sulfate, Ogen, Harmogen, Ortho-est, Estrone sulfate piperazine salt
    Molecular Formula
    C22H32N2O5S
    Molecular Weight
    436.6  g/mol
    InChI Key
    HZEQBCVBILBTEP-ZFINNJDLSA-N
    FDA UNII
    SVI38UY019
    Estropipate is a natural estrogenic substance composed of estrone sulfate and piperazine. Estropipate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate;piperazine
    2.1.2 InChI
    InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1
    2.1.3 InChI Key
    HZEQBCVBILBTEP-ZFINNJDLSA-N
    2.1.4 Canonical SMILES
    CC12CCC3C(C1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1
    2.1.5 Isomeric SMILES
    C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=C3C=CC(=C4)OS(=O)(=O)O.C1CNCCN1
    2.2 Other Identifiers
    2.2.1 UNII
    SVI38UY019
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, Compd. With Piperazine (1:1)

    2. Genoral

    3. Harmogen

    4. Harmonet

    5. Ogen

    6. Ortho-est

    7. Piperazine Estrone Sulfate

    2.3.2 Depositor-Supplied Synonyms

    1. 7280-37-7

    2. Piperazine Estrone Sulfate

    3. Ogen

    4. Harmogen

    5. Ortho-est

    6. Estrone Sulfate Piperazine Salt

    7. Sulestrex Piperazine

    8. Piperazine Estrone Sulphate

    9. Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, Compd. With Piperazine (1:1)

    10. Svi38uy019

    11. Piperazine Estronesulfate

    12. Nsc-758912

    13. Estrone Hydrogen Sulfate Compound With Piperazine (1:1)

    14. Sulestrex

    15. Unii-svi38uy019

    16. Piperazine (8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6h-cyclopenta[a]phenanthren-3-yl Sulfate

    17. Ogen 5

    18. Pipestrone

    19. Estropipate [usp:inn:ban]

    20. Ogen 2.5

    21. Ogen .625

    22. Ogen 1.25

    23. Einecs 230-696-3

    24. Estropipate (usp)

    25. Ogen (tn)

    26. Piperazineestronesulfate

    27. Ncgc00016682-02

    28. Dsstox_cid_3005

    29. Cas-7280-37-7

    30. Estropipate [vandf]

    31. Piperazine Oestrone Sulphate

    32. Conjugated Estrogens: Piperazine Estrone Sulfate

    33. Dsstox_rid_76828

    34. Estropipate [mart.]

    35. Dsstox_gsid_23005

    36. Schembl21577

    37. Estropipate [usp-rs]

    38. Estropipate [who-dd]

    39. Mls002153957

    40. Chebi:4873

    41. Chembl1200980

    42. Dtxsid3023005

    43. Piperazine, Compd. With Estrone Hydrogen Sulfate (1:1)

    44. Estrone, Hydrogen Sulfate, Compd. With Piperazine (1:1)

    45. Estropipate [orange Book]

    46. Hms1570i17

    47. Hms2097i17

    48. Hms2232o19

    49. Hms3714i17

    50. Estropipate [usp Monograph]

    51. Bcp05424

    52. Hy-b1361

    53. Tox21_113350

    54. S5288

    55. Akos024457702

    56. Estra-1,3,5(10)-trien-17-one 3-sulphate, Compound With Piperazine (1:1)

    57. Piperazine, Compd. With 3-(sulfooxy)estra-1,3,5(10)-trien-17-one (1:1)

    58. Bcp9000662

    59. Ccg-220688

    60. Cs-4818

    61. Estropipate, >=98% (hplc), Powder

    62. Nsc 758912

    63. [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Hydrogen Sulfate,piperazine

    64. Smr001233296

    65. Am20080957

    66. Estrone Sulfate Piperazine Salt [mi]

    67. D00948

    68. 280e377

    69. A837628

    70. Sr-01000000235

    71. Q5401860

    72. Sr-01000000235-5

    73. Estrone Hydrogen Sulphate Compound With Piperazine (1:1)

    74. Estropipate, United States Pharmacopeia (usp) Reference Standard

    75. 17-oxoestra-1,3,5(10)-trien-3-yl Hydrogen Sulfate - Piperazine (1:1)

    76. [(8r,9s,13s,14s)-13-methyl-17-oxidanylidene-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Hydrogen Sulfate; Piperazine

    77. [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Hydrogen Sulfate;piperazine

    78. Piperazine; Sulfuric Acid [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] Ester

    2.4 Create Date
    2005-11-20
    3 Chemical and Physical Properties
    Molecular Weight 436.6 g/mol
    Molecular Formula C22H32N2O5S
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count2
    Exact Mass436.20319330 g/mol
    Monoisotopic Mass436.20319330 g/mol
    Topological Polar Surface Area113 Ų
    Heavy Atom Count30
    Formal Charge0
    Complexity650
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 10  
    Drug NameEstropipate
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength1.5mg; 3mg; 0.75mg
    Market StatusPrescription
    CompanyWatson Labs; Mylan; Barr

    2 of 10  
    Drug NameOgen .625
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength0.75mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    3 of 10  
    Drug NameOgen 1.25
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength1.5mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    4 of 10  
    Drug NameOgen 2.5
    PubMed HealthEstropipate
    Drug ClassesEndocrine-Metabolic Agent, Female Reproductive Agent, Musculoskeletal Agent
    Drug LabelEstropipate (formerly piperazine estrone sulfate), is a natural estrogenic substance prepared from purified crystalline estrone, solubilized as the sulfate and stabilized with piperazine. It is appreciably soluble in water and has almost no odor or t...
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength3mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    5 of 10  
    Drug NameOgen 5
    PubMed HealthEstrogen
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength6mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    6 of 10  
    Drug NameEstropipate
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength1.5mg; 3mg; 0.75mg
    Market StatusPrescription
    CompanyWatson Labs; Mylan; Barr

    7 of 10  
    Drug NameOgen .625
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength0.75mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    8 of 10  
    Drug NameOgen 1.25
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength1.5mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    9 of 10  
    Drug NameOgen 2.5
    PubMed HealthEstropipate
    Drug ClassesEndocrine-Metabolic Agent, Female Reproductive Agent, Musculoskeletal Agent
    Drug LabelEstropipate (formerly piperazine estrone sulfate), is a natural estrogenic substance prepared from purified crystalline estrone, solubilized as the sulfate and stabilized with piperazine. It is appreciably soluble in water and has almost no odor or t...
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength3mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    10 of 10  
    Drug NameOgen 5
    PubMed HealthEstrogen
    Active IngredientEstropipate
    Dosage FormTablet
    RouteOral
    Strength6mg
    Market StatusPrescription
    CompanyPharmacia And Upjohn

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Contraceptive Agents, Hormonal

    Contraceptive agents that act on the ENDOCRINE SYSTEM. (See all compounds classified as Contraceptive Agents, Hormonal.)