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    Ethacizine

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Etacizin, Ethacizin, Ethacyzin, 33414-33-4, Etmozine daa, Nik-244
    Molecular Formula
    C22H27N3O3S
    Molecular Weight
    413.5  g/mol
    InChI Key
    PQXGNJKJMFUPPM-UHFFFAOYSA-N
    FDA UNII
    FE5SPV1Z6G
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    ethyl N-[10-[3-(diethylamino)propanoyl]phenothiazin-2-yl]carbamate
    2.1.2 InChI
    InChI=1S/C22H27N3O3S/c1-4-24(5-2)14-13-21(26)25-17-9-7-8-10-19(17)29-20-12-11-16(15-18(20)25)23-22(27)28-6-3/h7-12,15H,4-6,13-14H2,1-3H3,(H,23,27)
    2.1.3 InChI Key
    PQXGNJKJMFUPPM-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCC(=O)N1C2=CC=CC=C2SC3=C1C=C(C=C3)NC(=O)OCC
    2.2 Other Identifiers
    2.2.1 UNII
    FE5SPV1Z6G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 10-(3-(diethylamino)-1-oxopropyl)-10h-(phenothiazin-2-yl)carbamic Acid Ethyl Ester

    2. 2-(ethoxycarbonylamino)-10-(3-(diethylamino)propionyl)phenothiazine

    3. Etacizin

    4. Etacyzine

    5. Etatsizin

    6. Etatsizine

    7. Nik 244

    8. Nik0244

    2.3.2 Depositor-Supplied Synonyms

    1. Etacizin

    2. Ethacizin

    3. Ethacyzin

    4. 33414-33-4

    5. Etmozine Daa

    6. Nik-244

    7. Fe5spv1z6g

    8. Nsc-621878

    9. Ethyl N-[10-[3-(diethylamino)propanoyl]phenothiazin-2-yl]carbamate

    10. Ez-55

    11. Ethmozine Daa

    12. Ez 55

    13. Unii-fe5spv1z6g

    14. Brn 4827533

    15. Ethyl (10-(3-(diethylamino)-1-oxopropyl)-10h-phenothiazin-2-yl)carbamate

    16. Phenothiazine-2-carbamic Acid, 10-(n,n-diethyl-beta-alanyl)-, Ethyl Ester

    17. Ethacizine [mart.]

    18. Ethacizine [who-dd]

    19. Oprea1_817639

    20. Chembl1997663

    21. Schembl22882766

    22. Dtxsid50187057

    23. Chebi:134732

    24. Zinc4182572

    25. Nsc621878

    26. Stk995917

    27. Akos001680764

    28. Db13645

    29. Nsc 621878

    30. Carbamic Acid, (10-(3-(diethylamino)-1-oxopropyl)-10h-phenothiazin-2-yl)-, Ethyl Ester

    31. Nci60_006381

    32. D10503

    33. Q15408408

    34. Ethyl [10-(n,n-diethyl-beta-alanyl)-10h-phenothiazin-2-yl]carbamate

    35. Ethyl 10-(3-(diethylamino)propionyl)phenothiazine-2-carbamate

    36. Ethyl N-{10-[3-(diethylamino)propanoyl]-10h-phenothiazin-2-yl}carbamate

    37. 4596-66-1

    2.4 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 413.5 g/mol
    Molecular Formula C22H27N3O3S
    XLogP34.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count8
    Exact Mass413.17731291 g/mol
    Monoisotopic Mass413.17731291 g/mol
    Topological Polar Surface Area87.2 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity557
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    Psychotropic Drugs

    A loosely defined grouping of drugs that have effects on psychological function. Here the psychotropic agents include the antidepressive agents, hallucinogens, and tranquilizing agents (including the antipsychotics and anti-anxiety agents). (See all compounds classified as Psychotropic Drugs.)

    4.2 ATC Code

    C - Cardiovascular system

    C01 - Cardiac therapy

    C01B - Antiarrhythmics, class i and iii

    C01BC - Antiarrhythmics, class ic

    C01BC09 - Ethacizine