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    Ethambutol Dihydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DRUG PRODUCT COMPOSITIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

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    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 382Xls

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    2D Structure
    Also known as: Ethambutol dihydrochloride, Ethambutol hcl, 1070-11-7, Myambutol, Dadibutol, Dexambutol
    Molecular Formula
    C10H26Cl2N2O2
    Molecular Weight
    277.23  g/mol
    InChI Key
    AUAHHJJRFHRVPV-BZDVOYDHSA-N
    FDA UNII
    QE4VW5FO07
    An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2S)-2-[2-[[(2S)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;dihydrochloride
    2.1.2 InChI
    InChI=1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
    2.1.3 InChI Key
    AUAHHJJRFHRVPV-BZDVOYDHSA-N
    2.1.4 Canonical SMILES
    CCC(CO)NCCNC(CC)CO.Cl.Cl
    2.1.5 Isomeric SMILES
    CC[C@@H](CO)NCCN[C@@H](CC)CO.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    QE4VW5FO07
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dexambutol

    2. Emb Fatol

    3. Emb Hefa

    4. Emb-fatol

    5. Emb-hefa

    6. Etambutol Llorente

    7. Ethambutol

    8. Etibi

    9. Hydrochloride, Ethambutol

    10. Llorente, Etambutol

    11. Miambutol

    12. Myambutol

    2.3.2 Depositor-Supplied Synonyms

    1. Ethambutol Dihydrochloride

    2. Ethambutol Hcl

    3. 1070-11-7

    4. Myambutol

    5. Dadibutol

    6. Dexambutol

    7. Etibi

    8. Ethambutol (dihydrochloride)

    9. Servambutol

    10. Etapiam

    11. Mycobutol

    12. Tambutol

    13. Ebutol

    14. Cl 40881

    15. Tibutol

    16. (2s,2's)-2,2'-(ethane-1,2-diylbis(azanediyl))bis(butan-1-ol) Dihydrochloride

    17. Jng307dj5x

    18. Qe4vw5fo07

    19. Ethambutol Dihydrochloride, Dl-

    20. (+)-2,2'-(ethylenediimino)-di-1-butanol Dihydrochloride

    21. Nsc-757022

    22. Cl-40881

    23. 22196-75-4

    24. Dsstox_cid_25345

    25. Dsstox_rid_80813

    26. Dsstox_gsid_45345

    27. Ethambutol 2hcl

    28. Emb Dihydrochloride

    29. Chebi:4878

    30. (2s)-2-[2-[[(1s)-1-(hydroxymethyl)propyl]amino]ethylamino]butan-1-ol Dihydrochloride

    31. (2s)-2-[2-[[(2s)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol;dihydrochloride

    32. Ccris 6606

    33. Ncgc00178864-03

    34. Einecs 213-970-7

    35. Unii-jng307dj5x

    36. Unii-qe4vw5fo07

    37. (+-)-ethambutol Dihydrochloride

    38. Myambutol (tn)

    39. Ethambutol Hydrochloride [usan:usp:jan]

    40. Ethambutoli Hydrochloridum

    41. Emb

    42. Ncgc00016560-01

    43. Cas-1070-11-7

    44. (2s)-2-[(2-{[(2s)-1-hydroxybutan-2-yl]amino}ethyl)amino]butan-1-ol Dihydrochloride

    45. Schembl650049

    46. Spectrum1500288

    47. Chembl3140361

    48. Dtxsid4045345

    49. Hy-b0535a

    50. (+-)-2,2'-(ethylenediimino)-di-1-butanol Dihydrochloride

    51. Hms1920m18

    52. Kuc109574c

    53. (s-(r*,r*))-2,2'-(ethylenediimino)dibutan-1-ol Dihydrochloride

    54. Ksc-27-052b

    55. Tox21_110494

    56. 1-butanol, 2,2'-(ethylenediimino)di-, Dihydrochloride, (+)-

    57. Ccg-40232

    58. Mfcd21364080

    59. S4004

    60. Ethambutol Hydrochloride (jp17/usp)

    61. Ethambutol Hydrochloride [jan]

    62. 1-butanol, (1,2-ethanediyldiimino)bis-, Dihydrochloride, (r*,r*)-(+-)-

    63. Akos024258527

    64. Tox21_110494_1

    65. Cl40881

    66. Ethambutol Dihydrochloride [mi]

    67. Ethambutol Hydrochloride [usan]

    68. Nsc 757022

    69. 1-butanol, 2,2'-(1,2-ethanediyldiimino)bis-, Dihydrochloride, (r-(r*,r*))-

    70. 1-butanol, 2,2'-(1,2-ethanediyldiimino)bis-, Dihydrochloride, (s-(r*,r*))-

    71. Ethambutol Hydrochloride [mart.]

    72. Ethambutol Hydrochloride [vandf]

    73. Ethambutol Hydrochloride [usp-rs]

    74. Ethambutol Hydrochloride [who-ip]

    75. Ethambutol Dihydrochloride [who-dd]

    76. Ethambutol Dihydrochloride, Antimycobacterial

    77. E1011

    78. Sw219109-1

    79. Ethambutol Hydrochloride [ep Impurity]

    80. Ethambutol Hydrochloride [orange Book]

    81. D00878

    82. Ethambutol Hydrochloride [ep Monograph]

    83. Ethambutol Hydrochloride [usp Monograph]

    84. Ethambutoli Hydrochloridum [who-ip Latin]

    85. A895715

    86. Q27106530

    87. Z1558572530

    88. 2,2'-(1,2-ethanediyldiimino)bis-1-butanol Dihydrochloride

    89. 2,2'-[ethane-1,2-diyldi(imino)]dibutan-1-ol Dihydrochloride

    90. (s,s)-2,2'-(1,2-ethanediyldiimino)bis-1-butanol Dihydrochloride

    91. (s,s)-n,n'-bis(1-hydroxy-2-butyl)ethylenediamine Dihydrochloride

    92. 1-butanol, 2,2'-(1,2-ethanediyldiimino)bis-, Dihydrochloride, (r*,r*)-

    93. 1-butanol, 2,2'-(ethylenediimino)di-, Dihydrochloride, (+-)-

    94. Ethambutol Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    95. 1-butanol, 2,2'(1,2-ethanediyldiimino)bis-, Dihydrochloride, (-(r*,r*))

    96. 1-butanol, 2,2'-(1,2-ethanediyldiimino)bis-, Dihydrochloride, (2r,2'r)-rel-

    97. 1-butanol, 2,2'-(1,2-ethanediyldiimino)bis-, Hydrochloride (1:2), (2s,2's)-

    98. Ethambutol For System Suitability, European Pharmacopoeia (ep) Reference Standard

    99. Ethambutol Hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

    100. Ethambutol Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    101. 29326-86-1

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 277.23 g/mol
    Molecular Formula C10H26Cl2N2O2
    Hydrogen Bond Donor Count6
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count9
    Exact Mass276.1371335 g/mol
    Monoisotopic Mass276.1371335 g/mol
    Topological Polar Surface Area64.5 Ų
    Heavy Atom Count16
    Formal Charge0
    Complexity109
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameEthambutol hydrochloride
    Active IngredientEthambutol hydrochloride
    Dosage FormTablet
    RouteOral
    Strength100mg; 400mg
    Market StatusPrescription
    CompanyLupin; Barr

    2 of 2  
    Drug NameEthambutol hydrochloride
    Active IngredientEthambutol hydrochloride
    Dosage FormTablet
    RouteOral
    Strength100mg; 400mg
    Market StatusPrescription
    CompanyLupin; Barr

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antitubercular Agents

    Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. (See all compounds classified as Antitubercular Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Antimycobacterial [EPC]