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    Etidronate Disodium

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    DIGITAL CONTENT

    PATENTS & EXCLUSIVITIES

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: 7414-83-7, Didronel, Disodium etidronate, Sodium etidronate, Sodium ethidronate, Sodium ethydronate
    Molecular Formula
    C2H6Na2O7P2
    Molecular Weight
    249.99  g/mol
    InChI Key
    GWBBVOVXJZATQQ-UHFFFAOYSA-L
    FDA UNII
    M16PXG993G
    A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate
    2.1.2 InChI
    InChI=1S/C2H8O7P2.2Na/c1-2(3,10(4,5)6)11(7,8)9;;/h3H,1H3,(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
    2.1.3 InChI Key
    GWBBVOVXJZATQQ-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    M16PXG993G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (1-hydroxyethylene)diphosphonic Acid

    2. (1-hydroxyethylene)diphosphonic Acid, Tetrapotassium Salt

    3. 1 Hydroxyethane 1,1 Diphosphonate

    4. 1 Hydroxyethylidene 1,1 Bisphosphonate

    5. 1,1 Hydroxyethylenediphosphonate

    6. 1,1-hydroxyethylenediphosphonate

    7. 1-hydroxyethane-1,1-diphosphonate

    8. 1-hydroxyethylene Diphosphonate, Disodium

    9. 1-hydroxyethylidene-1,1-bisphosphonate

    10. Dicalcium Ehdp

    11. Dicalcium Etidronate

    12. Didronel

    13. Diphosphonate, Disodium 1-hydroxyethylene

    14. Diphosphonic Acid, Hydroxyethylidene

    15. Disodium 1 Hydroxyethylene Diphosphonate

    16. Disodium 1-hydroxyethylene Diphosphonate

    17. Disodium Etidronate

    18. Ehdp

    19. Ehdp, Dicalcium

    20. Ethanehydroxydiphosphonate

    21. Ethanehydroxyphosphate

    22. Etidronate

    23. Etidronate, Dicalcium

    24. Etidronate, Disodium

    25. Etidronate, Sodium

    26. Etidronate, Tetrapotassium Salt

    27. Etidronic Acid

    28. Hedp

    29. Hedspa

    30. Hydroxyethanediphosphonate

    31. Hydroxyethylidene Diphosphonic Acid

    32. Phosphonic Acid, (1-hydroxyethylidene)bis-, Disodium Salt

    33. Salt Etidronate, Tetrapotassium

    34. Sodium Etidronate

    35. Tetrapotassium Salt Etidronate

    36. Xidifon

    37. Xidiphon

    38. Xydiphone

    2.3.2 Depositor-Supplied Synonyms

    1. 7414-83-7

    2. Didronel

    3. Disodium Etidronate

    4. Sodium Etidronate

    5. Sodium Ethidronate

    6. Sodium Ethydronate

    7. Disodium Ethydronate

    8. Turpinal 2nz

    9. Disodium Ethanol-1,1-diphosphonate

    10. Etidronic Acid Disodium Salt

    11. Etidronatedisodium

    12. Disodium (1-hydroxyethylidene)diphosphonate

    13. Phosphonic Acid, (1-hydroxyethylidene)bis-, Disodium Salt

    14. Disodium 1-hydroxyethylidene Phosphonate

    15. Chebi:4906

    16. Hedpa;hedp

    17. Disodium Dihydrogen (1-hydroxyethylidene)diphosphonate

    18. Disodium Ethane-1-hydroxy-1,1-diphosphonate

    19. (1-hydroxyethylidene)diphosphonic Acid, Disodium Salt

    20. Etidronic Acid, Disodium Salt

    21. 1-hydroxyethylidene-1,1-diphosphonic Acid Disodium Salt

    22. (1-hydroxyethane-1,1-diyl)diphosphonic Acid Disodium Salt

    23. M16pxg993g

    24. Didronel R

    25. 1-hydroxyethane-1,1-diphosphonic Acid Disodium Salt

    26. Nsc-759157

    27. Cas-7414-83-7

    28. Dsstox_cid_9671

    29. Disodium;hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

    30. Dsstox_rid_78804

    31. Dsstox_gsid_29671

    32. Disodium (1-hydroxyethane-1,1-diyl)bis[hydrogen (phosphonate)]

    33. Etidronsaeure Dinatriumsalz

    34. Etidronate Disodium Hydrate

    35. Etidronic Acid Disodium

    36. Ncgc00159352-02

    37. 29329-71-3

    38. Einecs 231-025-7

    39. Sm-5600

    40. Unii-m16pxg993g

    41. Didronel Iv

    42. Didronel Pmo

    43. Phosphonic Acid, (1-hydroxyethylidene)bis-, Sodium Salt

    44. Didronel (tn)

    45. Ethane-1-hydroxy-1,1-diphosphonate, Disodium Salt

    46. Etidronate Disodium [usan:usp:jan]

    47. Mfcd00152567

    48. Prestwick_1061

    49. Disodium Dihydrogen (1-hydroxyethylidene)bisphosphonate

    50. Ethane-1-hydroxy-1,1-diphosphonic Acid, Disodium Salt

    51. Phosphonic Acid, (1-hydroxyethylidene)di-, Disodium Salt

    52. Disodium Hydroxy-[1-hydroxy-1-[hydroxy(oxido)phosphoryl]ethyl]phosphinate

    53. Chembl1201042

    54. Dtxsid1029671

    55. Etidronate Disodium [jan]

    56. Etidronate Disodium (jp17/usp)

    57. Disodium Etidronate [inci]

    58. Etidronate Disodium [usan]

    59. Hms1570n07

    60. Hms2093p03

    61. Hms2097n07

    62. Etidronate Disodium [vandf]

    63. Bcp22743

    64. Etidronate Disodium [mart.]

    65. Tox21_111596

    66. Bdbm50247999

    67. Etidronate Disodium [usp-rs]

    68. Etidronate Disodium [who-dd]

    69. Phosphonic Acid, P,p'-(1-hydroxyethylidene)bis-, Sodium Salt (1:2)

    70. Akos015961949

    71. Tox21_111596_1

    72. Ac-2078

    73. Ccg-213569

    74. Ks-1297

    75. Nsc 759157

    76. Etidronate Disodium [orange Book]

    77. Ncgc00017072-01

    78. Ncgc00179380-04

    79. Be164429

    80. Etidronate Disodium [ep Monograph]

    81. Etidronic Acid Disodium Salt [mi]

    82. Etidronate Disodium [usp Monograph]

    83. Disodium 1-hydroxyethane-1,1-diphosphonate

    84. D4159

    85. Ft-0630369

    86. D00314

    87. H11387

    88. Etidronate Disodium;hedpa Disodium;hedp Disodium

    89. A838033

    90. Etidronate Disodium Hydrate, >=97% (nmr), Solid

    91. W-104431

    92. 1-hydroxyethane 1,1-diphosphonic Acid Disodium Salt

    93. Disodium Etidronate;sm-5600; Sm-5600; Sm-5600

    94. Q27106537

    95. Sodium 1-hydroxyethane-1,1-diylbis(hydrogenphosphonate)

    96. Disodium [1-[oxidanidyl(oxidanyl)phosphoryl]-1-oxidanyl-ethyl]-oxidanyl-phosphinate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 249.99 g/mol
    Molecular Formula C2H6Na2O7P2
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count2
    Exact Mass249.93841509 g/mol
    Monoisotopic Mass249.93841509 g/mol
    Topological Polar Surface Area141 Ų
    Heavy Atom Count13
    Formal Charge0
    Complexity206
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameDidronel
    Active IngredientEtidronate disodium
    Dosage FormTablet
    RouteOral
    Strength200mg; 400mg
    Market StatusPrescription
    CompanyProcter And Gamble

    2 of 4  
    Drug NameEtidronate disodium
    PubMed HealthEtidronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelEtidronate disodium tablets, USP contain either 200 mg or 400 mg of etidronate disodium, the disodium salt of (1-hydroxyethylidene) diphosphonic acid, for oral administration. This compound, also known as EHDP, regulates bone metabolism. Etidronate d...
    Active IngredientEtidronate disodium
    Dosage FormTablet
    RouteOral
    Strength200mg; 400mg
    Market StatusPrescription
    CompanyMylan

    3 of 4  
    Drug NameDidronel
    Active IngredientEtidronate disodium
    Dosage FormTablet
    RouteOral
    Strength200mg; 400mg
    Market StatusPrescription
    CompanyProcter And Gamble

    4 of 4  
    Drug NameEtidronate disodium
    PubMed HealthEtidronate (By mouth)
    Drug ClassesCalcium Regulator
    Drug LabelEtidronate disodium tablets, USP contain either 200 mg or 400 mg of etidronate disodium, the disodium salt of (1-hydroxyethylidene) diphosphonic acid, for oral administration. This compound, also known as EHDP, regulates bone metabolism. Etidronate d...
    Active IngredientEtidronate disodium
    Dosage FormTablet
    RouteOral
    Strength200mg; 400mg
    Market StatusPrescription
    CompanyMylan

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Bone Density Conservation Agents

    Agents that inhibit BONE RESORPTION and/or favor BONE MINERALIZATION and BONE REGENERATION. They are used to heal BONE FRACTURES and to treat METABOLIC BONE DISEASES such as OSTEOPOROSIS. (See all compounds classified as Bone Density Conservation Agents.)