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    Fasudil

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: 105628-07-7, Fasudil hcl, Eril, Fasudil (ha-1077) hcl, 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline hydrochloride, Fasudil (hydrochloride)
    Molecular Formula
    C14H18ClN3O2S
    Molecular Weight
    327.8  g/mol
    InChI Key
    LFVPBERIVUNMGV-UHFFFAOYSA-N
    FDA UNII
    SQ04N8S7BR
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride
    2.1.2 InChI
    InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H
    2.1.3 InChI Key
    LFVPBERIVUNMGV-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    SQ04N8S7BR
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(5-isoquinolinesulfonyl)homopiperazine

    2. At 877

    3. At-877

    4. At877

    5. Fasudil

    6. Fasudil Mesylate

    7. Ha 1077

    8. Ha-1077

    2.3.2 Depositor-Supplied Synonyms

    1. 105628-07-7

    2. Fasudil Hcl

    3. Eril

    4. Fasudil (ha-1077) Hcl

    5. 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline Hydrochloride

    6. Fasudil (hydrochloride)

    7. At-877

    8. Fasudil Monohydrochloride

    9. Ha-1077

    10. Sq04n8s7br

    11. Fasudil, Monohydrochloride Salt

    12. 105628-07-7 (hcl)

    13. 1h-1,4-diazepine, Hexahydro-1-(5-isoquinolinylsulfonyl)-, Monohydrochloride

    14. Dsstox_cid_25615

    15. Dsstox_rid_81004

    16. Dsstox_gsid_45615

    17. Fasudil Hydrochloride (jan)

    18. 1-(5-isoquinolinesulfonyl)homopiperazine Hydrochloride

    19. Chembl541388

    20. Ha-1077 Hydrochloride

    21. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydrochloride

    22. 5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline Xhydrochloride

    23. At 877 Hydrochloride

    24. Fasudil Hydrochloride [jan]

    25. Ha 1077 Hydrochloride

    26. Ha-1077 Dihydrochloride

    27. 133337-43-6

    28. Cas-105628-07-7

    29. Ncgc00018100-04

    30. Unii-sq04n8s7br

    31. C14h17n3o2s.hcl

    32. Fasdil

    33. Fasudil-ha

    34. Calciumcyclamate

    35. Fasudil, Monohcl

    36. Hexahydro-1-(5-isoquinolinylsulfonyl)-1h-1,4-diazepine Monohydrochloride

    37. Regid_for_cid_4917

    38. Bmk1-e2

    39. Mls000069344

    40. Schembl317082

    41. Fasudil Hcl (ha-1077)

    42. Fasudil Hcl - Ha-1077

    43. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline Hydrochloride

    44. Dtxsid1045615

    45. Regid_for_cid_163751

    46. Chebi:31593

    47. Fasudil Hydrochloride [mi]

    48. Act06296

    49. Bcp26351

    50. Tox21_110824

    51. Mfcd00943198

    52. S1573

    53. Fasudil Hydrochloride [mart.]

    54. Akos015897321

    55. Fasudil Hydrochloride [who-dd]

    56. Tox21_110824_1

    57. Ac-4515

    58. Ccg-267783

    59. Cs-0225

    60. Ncgc00018100-08

    61. Ncgc00180915-01

    62. 111ge018

    63. As-17751

    64. Hy-10341

    65. Smr000058993

    66. Am20050635

    67. F0839

    68. Ft-0631034

    69. Sw218155-2

    70. A21128

    71. D01840

    72. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline Hcl

    73. Sr-01000000005

    74. 1-(5isoquinolinesulfonyl)homopiperazine Hydrochloride

    75. Sr-01000000005-2

    76. Q27289337

    77. 1-(5-isoquinolinesulfonyl)homopiperazine Dihydrochloride

    78. 5-(1-homopiperazinyl)sulfonylisoquinoline Hydrochloride

    79. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline;hydron;chloride

    80. 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline Hydrochloride (1:1)

    81. 5-(hexahydro-1h-1,4-diazepine-1-ylsulfonyl)isoquinoline Hydrochloride

    82. Isoquinoline, 5-((hexahydro-1h-1,4-diazepin-1-yl)sulfonyl)-, Hydrochloride (1:1)

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 327.8 g/mol
    Molecular Formula C14H18ClN3O2S
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass327.0808257 g/mol
    Monoisotopic Mass327.0808257 g/mol
    Topological Polar Surface Area70.7 Ų
    Heavy Atom Count21
    Formal Charge0
    Complexity421
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of non-traumatic subarachnoid haemorrhage

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Calcium Channel Blockers

    A class of drugs that act by selective inhibition of calcium influx through cellular membranes. (See all compounds classified as Calcium Channel Blockers.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    Protein Kinase Inhibitors

    Agents that inhibit PROTEIN KINASES. (See all compounds classified as Protein Kinase Inhibitors.)