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    Fenoldopam Mesylate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    EXCIPIENTS BY APPLICATIONS

    GLOBAL SALES INFORMATION

    REF. STANDARDS & IMPURITIES

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    $ API Ref.Price (USD/KG) : 14,217Xls

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    2D Structure
    Also known as: 67227-57-0, Corlopam, Fenoldopam methanesulfonate, Fenoldopam (mesylate), Fenoldopam mesilate, Corlopam mesylate
    Molecular Formula
    C17H20ClNO6S
    Molecular Weight
    401.9  g/mol
    InChI Key
    CVKUMNRCIJMVAR-UHFFFAOYSA-N
    FDA UNII
    HA3R0MY016
    A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;methanesulfonic acid
    2.1.2 InChI
    InChI=1S/C16H16ClNO3.CH4O3S/c17-15-11-5-6-18-8-13(9-1-3-10(19)4-2-9)12(11)7-14(20)16(15)21;1-5(2,3)4/h1-4,7,13,18-21H,5-6,8H2;1H3,(H,2,3,4)
    2.1.3 InChI Key
    CVKUMNRCIJMVAR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CS(=O)(=O)O.C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=C(C=C3)O
    2.2 Other Identifiers
    2.2.1 UNII
    HA3R0MY016
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Corlopam

    2. Fenoldopam

    3. Fenoldopam Hydrobromide

    4. Hydrobromide, Fenoldopam

    5. Sk And F 82526

    6. Sk And F 82526j

    7. Sk And F-82526

    8. Sk And F-82526j

    9. Sk And F82526

    10. Sk And F82526j

    11. Skf 82526

    12. Skf 82526j

    13. Skf-82526

    14. Skf-82526j

    15. Skf82526

    16. Skf82526j

    2.3.2 Depositor-Supplied Synonyms

    1. 67227-57-0

    2. Corlopam

    3. Fenoldopam Methanesulfonate

    4. Fenoldopam (mesylate)

    5. Fenoldopam Mesilate

    6. Corlopam Mesylate

    7. Sk&f 82526-j

    8. Fendolopam Mesylate

    9. Nsc-759860

    10. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;methanesulfonic Acid

    11. Ha3r0my016

    12. Sk&f-82526j

    13. 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Methanesulfonate (salt)

    14. Fenoldopam Methanesulfonate;skf-82526 Mesylate

    15. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol,methanesulfonic Acid

    16. 1h-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, Methanesulfonate (salt)

    17. Mls001401388

    18. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-benzo[d]azepine-7,8-diol Methanesulfonate

    19. Einecs 266-612-7

    20. Fenoldopam Mesylate [usan]

    21. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol; Methanesulfonic Acid

    22. Fenoldopam Monomethanesulfonate

    23. Sk-82526-j

    24. Skf 82526-j

    25. Smr000469190

    26. Unii-ha3r0my016

    27. Skf 82526 (mesylate)

    28. Fenoldopam Mesylate [usan:usp]

    29. Corlopam (tn)

    30. Skf-82526 Mesylate

    31. Fenoldopam Mesylate (usp)

    32. Chembl1026

    33. Schembl41213

    34. 6-chloro-2,3,4,5-tetrahydro-7,8-dihydroxy-1-(p-hydroxyphenyl)-1h-3-benzazepinium Methanesulphonate

    35. 9-chloro-5-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol; Methanesulfonic Acid

    36. Chebi:5003

    37. Hy-b0735a

    38. Dtxsid00904650

    39. Hms2051p09

    40. Hms2230j03

    41. Hms3264b10

    42. Hms3371l12

    43. Hms3393p09

    44. Hms3885l10

    45. Pharmakon1600-01505539

    46. Fenoldopam Mesylate [vandf]

    47. Fenoldopam Mesilate [mart.]

    48. Fenoldopam Mesilate [who-dd]

    49. Fenoldopam Mesylate [usp-rs]

    50. Nsc759860

    51. S4618

    52. Sk&f-82526-j

    53. Akos030254549

    54. Fenoldopam Mesylate, >=98% (hplc)

    55. Ccg-100942

    56. Ccg-213480

    57. M27f569

    58. Nc00192

    59. Nsc 759860

    60. Fenoldopam Methanesulfonate [mi]

    61. Fenoldopam Mesylate [orange Book]

    62. Ac-32753

    63. As-57125

    64. Fenoldopam Mesylate [usp Monograph]

    65. Db-054999

    66. Ft-0626401

    67. C76117

    68. D00613

    69. A835665

    70. W-104725

    71. Q27279818

    72. Z2210694608

    73. Fenoldopam Mesylate, United States Pharmacopeia (usp) Reference Standard

    74. 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Mesylate

    75. 1h-3-benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-, Methanesulphonate (salt)

    76. 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol;methanesulfonic Acid

    77. 6-chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1h-3-benzazepine-7,8-diol Methanesulphonate (salt)

    78. 6-chloro-7,8-dihydroxy-1-(p-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine Methane Sulfonate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 401.9 g/mol
    Molecular Formula C17H20ClNO6S
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count1
    Exact Mass401.0699862 g/mol
    Monoisotopic Mass401.0699862 g/mol
    Topological Polar Surface Area136 Ų
    Heavy Atom Count26
    Formal Charge0
    Complexity441
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameCorlopam
    PubMed HealthFenoldopam (Injection)
    Drug ClassesAntihypertensive
    Drug LabelCorlopam (Fenoldopam Mesylate Injection, USP) is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-...
    Active IngredientFenoldopam mesylate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 10mg base/ml
    Market StatusPrescription
    CompanyHospira

    2 of 4  
    Drug NameFenoldopam mesylate
    Drug LabelFenoldopam Mesylate Injection, USP is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-7,8-diol me...
    Active IngredientFenoldopam mesylate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 10mg base/ml
    Market StatusPrescription
    CompanyEurohlth Intl; Sandoz

    3 of 4  
    Drug NameCorlopam
    PubMed HealthFenoldopam (Injection)
    Drug ClassesAntihypertensive
    Drug LabelCorlopam (Fenoldopam Mesylate Injection, USP) is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-...
    Active IngredientFenoldopam mesylate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 10mg base/ml
    Market StatusPrescription
    CompanyHospira

    4 of 4  
    Drug NameFenoldopam mesylate
    Drug LabelFenoldopam Mesylate Injection, USP is a dopamine D1-like receptor agonist. The product is formulated as a solution to be diluted for intravenous infusion. Chemically it is 6-chloro-2,3,4,5-tetrahydro-1-(4-hydroxyphenyl)-[1H]-3-benzazepine-7,8-diol me...
    Active IngredientFenoldopam mesylate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 10mg base/ml
    Market StatusPrescription
    CompanyEurohlth Intl; Sandoz

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Dopamine Agonists

    Drugs that bind to and activate dopamine receptors. (See all compounds classified as Dopamine Agonists.)

    Vasodilator Agents

    Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Dopaminergic Agonist [EPC]; Dopamine Agonists [MoA]