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    Technical details about Fenquizone, learn more about the structure, uses, toxicity, action, side effects and more

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    Fenquizone

    DOSSIERs // Finished Dosage Forms

    GLOBAL SALES INFORMATION

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    Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients & provides custom-made solutions.

    2D Structure
    1. Also known as: 20287-37-0, Idrolone, M.g. 13054, Lj1u13r8ik, 7-chloro-4-oxo-2-phenyl-2,3-dihydro-1h-quinazoline-6-sulfonamide, Mg-13054
    Molecular Formula
    C14H12ClN3O3S
    Molecular Weight
    337.8  g/mol
    InChI Key
    DBDTUXMDTSTPQZ-UHFFFAOYSA-N
    FDA UNII
    LJ1U13R8IK
    Fenquizone is a quinazolinone sulphonamide-based diuretic, structurally related to metolazone, with thiazide-like activity. As a thiazide-like diuretic, fenquizone acts by blocking reabsorption of sodium in the proximal tubule and the ascending branch of the loop of Henle. This causes an increase in diuresis with the elimination of chloride and sodium.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    7-chloro-4-oxo-2-phenyl-2,3-dihydro-1H-quinazoline-6-sulfonamide
    2.1.2 InChI
    InChI=1S/C14H12ClN3O3S/c15-10-7-11-9(6-12(10)22(16,20)21)14(19)18-13(17-11)8-4-2-1-3-5-8/h1-7,13,17H,(H,18,19)(H2,16,20,21)
    2.1.3 InChI Key
    DBDTUXMDTSTPQZ-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1=CC=C(C=C1)C2NC3=CC(=C(C=C3C(=O)N2)S(=O)(=O)N)Cl
    2.2 Other Identifiers
    2.2.1 UNII
    LJ1U13R8IK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Idrolone

    2. Mg 13054

    2.3.2 Depositor-Supplied Synonyms

    1. 20287-37-0

    2. Idrolone

    3. M.g. 13054

    4. Lj1u13r8ik

    5. 7-chloro-4-oxo-2-phenyl-2,3-dihydro-1h-quinazoline-6-sulfonamide

    6. Mg-13054

    7. Fenchizone

    8. Fenquizona

    9. Fenquizonum

    10. Fenchizone [dcit]

    11. Fenquizone [usan:inn]

    12. Fenquizonum [inn-latin]

    13. Fenquizona [inn-spanish]

    14. Unii-lj1u13r8ik

    15. Einecs 243-689-5

    16. Fenquizone [mi]

    17. Fenquizone [inn]

    18. Fenquizone (usan/inn)

    19. Fenquizone [usan]

    20. Fenquizone [mart.]

    21. Fenquizone [who-dd]

    22. Schembl309550

    23. Chembl2106186

    24. Dtxsid10864933

    25. Chebi:135435

    26. Ex-a6134

    27. (+-)-7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-6-quinazolinesulfonamide

    28. Db13708

    29. Hy-126179

    30. Cs-0092520

    31. D04161

    32. Q3742488

    33. 2-phenyl-7-chloro-6-sulfamoyl-1,2,3,4-tetrahydro-4-quinazolinone

    34. 2-phenyl-6-sulfonamido-7-chloro-1,2,3,4-tetrahydro-4-quinazolidone

    35. 7-chloro-4-oxo-2-phenyl-1,2,3,4-tetrahydroquinazoline-6-sulfonamide

    36. (+/-)-7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-6-quinazolinesulfonamide

    37. 6-quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-, (+-)-

    38. 6-quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-4-oxo-2-phenyl-, (+/-)-

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 337.8 g/mol
    Molecular Formula C14H12ClN3O3S
    XLogP31.8
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count2
    Exact Mass337.0287901 g/mol
    Monoisotopic Mass337.0287901 g/mol
    Topological Polar Surface Area110 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity530
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Diuretics

    Agents that promote the excretion of urine through their effects on kidney function. (See all compounds classified as Diuretics.)

    4.2 ATC Code

    C - Cardiovascular system

    C03 - Diuretics

    C03B - Low-ceiling diuretics, excl. thiazides

    C03BA - Sulfonamides, plain

    C03BA13 - Fenquizone

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