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    Fenspiride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

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    PharmaCompass
    $ API Ref.Price (USD/KG) : 465Xls

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    2D Structure
    Also known as: 5053-06-5, Respiride, 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one, Fenspiride [inn], 8-phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, Eurespal
    Molecular Formula
    C15H20N2O2
    Molecular Weight
    260.33  g/mol
    InChI Key
    FVNFBBAOMBJTST-UHFFFAOYSA-N
    FDA UNII
    S983QC7HKM
    Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
    2.1.2 InChI
    InChI=1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18)
    2.1.3 InChI Key
    FVNFBBAOMBJTST-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3
    2.2 Other Identifiers
    2.2.1 UNII
    S983QC7HKM
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3612 S

    2. 3612-s

    3. Decaspiride

    4. Espiran

    5. Fenspiride Hydrochloride

    6. Pneumorel

    2.3.2 Depositor-Supplied Synonyms

    1. 5053-06-5

    2. Respiride

    3. 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

    4. Fenspiride [inn]

    5. 8-phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

    6. Eurespal

    7. 8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

    8. S983qc7hkm

    9. Fenspiride (inn)

    10. 1-oxa-3,8-diazaspiro(4,5)decan-2-one, 8-(2-phenylethyl)-

    11. Viarespan

    12. Fenspiridum [inn-latin]

    13. Fenspirida [inn-spanish]

    14. Fenspirida

    15. Fenspiridum

    16. 8-phenethyl-1-oxa-3,8-diazaspiro(4.5)decan-2-one

    17. Eurespal (tn)

    18. Einecs 225-751-3

    19. Brn 0533332

    20. Spectrum_001260

    21. Fenspiride [mi]

    22. Prestwick0_000213

    23. Prestwick1_000213

    24. Prestwick2_000213

    25. Prestwick3_000213

    26. Spectrum2_001396

    27. Spectrum3_001435

    28. Spectrum4_000415

    29. Spectrum5_001345

    30. Lopac-f-6145

    31. Unii-s983qc7hkm

    32. Fenspiride [who-dd]

    33. Lopac0_000496

    34. Schembl21016

    35. Bspbio_000225

    36. Bspbio_003170

    37. Kbiogr_000710

    38. Kbioss_001740

    39. Divk1c_000526

    40. Spbio_001412

    41. Spbio_002146

    42. Bpbio1_000249

    43. Chembl576127

    44. Zinc1441

    45. Dtxsid4023048

    46. Chebi:94558

    47. Hy-a0027a

    48. Kbio1_000526

    49. Kbio2_001740

    50. Kbio2_004308

    51. Kbio2_006876

    52. Kbio3_002390

    53. Ninds_000526

    54. Bcp07882

    55. Mfcd00867054

    56. Akos013605285

    57. Ccg-204587

    58. Db08979

    59. Sb37403

    60. Sdccgsbi-0050480.p004

    61. Cas-1151830

    62. Idi1_000526

    63. Ncgc00015438-01

    64. Ncgc00015438-02

    65. Ncgc00015438-03

    66. Ncgc00015438-04

    67. Ncgc00015438-13

    68. Ncgc00016988-01

    69. Ncgc00162172-01

    70. Ac-25697

    71. Sbi-0050480.p003

    72. Ab00053591

    73. Cs-0013596

    74. Ft-0650682

    75. D07949

    76. Ab00053591_10

    77. Ab00053591_11

    78. 053f065

    79. A913266

    80. Q518027

    81. 8-phenethyl-1-oxa-3,8-diaza-spiro4.5decan-2-one

    82. Brd-k26739552-003-05-5

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 260.33 g/mol
    Molecular Formula C15H20N2O2
    XLogP32.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count3
    Rotatable Bond Count3
    Exact Mass260.152477885 g/mol
    Monoisotopic Mass260.152477885 g/mol
    Topological Polar Surface Area41.6 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity318
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Bronchodilator Agents

    Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)

    4.2 ATC Code

    R - Respiratory system

    R03 - Drugs for obstructive airway diseases

    R03B - Other drugs for obstructive airway diseases, inhalants

    R03BX - Other drugs for obstructive airway diseases, inhalants

    R03BX01 - Fenspiride

    R - Respiratory system

    R03 - Drugs for obstructive airway diseases

    R03D - Other systemic drugs for obstructive airway diseases

    R03DX - Other systemic drugs for obstructive airway diseases

    R03DX03 - Fenspiride