1. Accrufer
2. Iron (iii) Maltol
3. Iron(3+) Tris(2-methyl-4-oxo-4h-pyran-3-olate)
1. 33725-54-1
2. Iron (iii) Maltol
3. Ferric Maltol [inn]
4. Ferric Maltol [usan]
5. St10
6. Ma10qyf1z0
7. Iron(3+);2-methyl-4-oxopyran-3-olate
8. Iron(iii) 2-methyl-4-oxo-4h-pyran-3-olate
9. St10-021
10. Iron Maltol
11. Feraccru (tn)
12. Unii-ma10qyf1z0
13. Ferric Maltol [mi]
14. Ferric Maltol (usan/inn)
15. Ferric Maltol [usan:inn]
16. Ferric Maltol [who-dd]
17. St-10
18. Ferric Maltol [orange Book]
19. Who 9974
20. Db15598
21. Iron(iii)2-methyl-4-oxo-4h-pyran-3-olate
22. D10833
23. E83926
24. Q27283748
25. Iron, Tris(3-hydroxy-2-methyl-4h-pyran-4-onato-o3,o4)-
26. Iron, Tris(3-(hydroxy-.kappa.o)-2-methyl-4h-pyran-4-onato-.kappa.o4)-
27. Tris(3-(hydroxy-.kappa.o)-2-methyl-4h-pyran-4-onato-.kappa.o4)iron(iii)
| Molecular Weight | 431.2 g/mol |
|---|---|
| Molecular Formula | C18H15FeO9 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 0 |
| Exact Mass | 431.006543 g/mol |
| Monoisotopic Mass | 431.006543 g/mol |
| Topological Polar Surface Area | 148 Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 200 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 4 |
Ferric maltol is indicated to treat iron deficiency in adults.
Feraccru is indicated in adults for the treatment of iron deficiency.
Treatment of iron deficiency
Ferric maltol is used to provide supplemental iron to patients with an iron deficiency. It has a wide therapeutic index as patients generally take 30mg twice daily, while concentrations of 20mg/kg may produce toxicity. Patients should be counselled regarding the risk of inflammatory bowel disease flares, iron overload, and accidental ingestion in children.
Hematinics
Agents which improve the quality of the blood, increasing the hemoglobin level and the number of erythrocytes. They are used in the treatment of anemias. (See all compounds classified as Hematinics.)
B03AB
B - Blood and blood forming organs
B03 - Antianemic preparations
B03A - Iron preparations
B03AB - Iron trivalent, oral preparations
B03AB10 - Ferric maltol
Absorption
Ferric maltol dissociates in the gastrointestinal tract, leading to a Tmax of 1.5-3.0 hours for iron concentrations. Mean serum iron increases by 146mol/L in iron deficient patients following a single dose. a 60mg dose is approximately 14% bioavailable. 60 minutes after injection of radiolabelled ferric maltol, 11+2% of the dose is present in the bone marrow, 181% is present in the liver, and 2.61% is in the urine. Maltol has an AUC of 0.022-0.205h\*g/mL and maltol glucuronide has an AUC of 9.83-30.9h\*g/mL.
Route of Elimination
39.8-60% of an oral dose of ferric maltol is excreted in the urine as a glucuronide conjugate. Iron and ferric maltol are not excreted in the urine and unabsorbed ferric maltol is eliminated in the feces.
Volume of Distribution
Data regarding the volume of distribution of ferric maltol is not readily available.
Clearance
Data regarding the clearance of ferric maltol is not readily available.
_In vitro_, ferric maltol metabolism is predominantly glucuronidation of maltol by UGT1A6 and sulfation.
Maltol has a half life of 0.7h.
Ferric maltol dissociates as the iron atom is donated to unknown iron uptake mechanisms, possibly beta 3 integrin or divalent metal transporter 1, in the ileum and duodenum. Once the iron is in circulation, it then associates with transferrin and ferritin.
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