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    Technical details about Ferrous Fumarate, learn more about the structure, uses, toxicity, action, side effects and more

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    Ferrous Fumarate

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: Iron(ii) fumarate, 141-01-5, Feostat, Palafer, Galfer, Ircon
    Molecular Formula
    C4H2FeO4
    Molecular Weight
    169.90  g/mol
    InChI Key
    PMVSDNDAUGGCCE-TYYBGVCCSA-L
    FDA UNII
    R5L488RY0Q
    Ferrous Fumarate is the fumarate salt form of the mineral iron. Administration of ferrous fumarate results in elevation of serum iron concentration, which is then assimilated into hemoglobin, required for the transport of oxygen, or trapped in the reticuloendothelial cells for storage. This agent is used as a dietary supplement, and to prevent or treat iron deficiency related syndromes.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (E)-but-2-enedioate;iron(2+)
    2.1.2 InChI
    InChI=1S/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;
    2.1.3 InChI Key
    PMVSDNDAUGGCCE-TYYBGVCCSA-L
    2.1.4 Canonical SMILES
    C(=CC(=O)[O-])C(=O)[O-].[Fe+2]
    2.1.5 Isomeric SMILES
    C(=C/C(=O)[O-])\C(=O)[O-].[Fe+2]
    2.2 Other Identifiers
    2.2.1 UNII
    R5L488RY0Q
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Feostat

    2. Ferrocap

    3. Fersaday

    4. Fersamal

    5. Ferval

    6. Fumar

    7. Galfer

    8. Ircon

    9. Nephro-fer

    10. Palafer

    11. Rulofer N

    2.3.2 Depositor-Supplied Synonyms

    1. Iron(ii) Fumarate

    2. 141-01-5

    3. Feostat

    4. Palafer

    5. Galfer

    6. Ircon

    7. Ercoferro

    8. Ferrofume

    9. Tolferain

    10. Cpiron

    11. Hemoton

    12. Toleron

    13. Tolifer

    14. Erco-fer

    15. Ferrousfumarate

    16. Iron(2+) Fumarate

    17. Iron Fumarate

    18. 2-butenedioic Acid (2e)-, Iron(2+) Salt (1:1)

    19. Fumaric Acid, Iron(2+) Salt (1:1)

    20. 2-butenedioic Acid (e)-, Iron(2+) Salt (1:1)

    21. R5l488ry0q

    22. 2-butenedioic Acid, (e)-, Iron(2+) Salt

    23. Fersamal

    24. Fumar

    25. (e)-but-2-enedioate;iron(2+)

    26. Feroton

    27. Ferronat

    28. Ferrone

    29. Ferrotemp

    30. Fumafer

    31. Fumiron

    32. Firon

    33. One-iron

    34. Fumar-f

    35. Ferrocite

    36. Fumaric Acid, Iron(2+) Salt

    37. Ccris 6896

    38. Einecs 205-447-7

    39. Unii-r5l488ry0q

    40. Ferrofumarate

    41. Heferol

    42. Orgasal

    43. Ferrous Fumarate [usp:jan]

    44. Feostat (tn)

    45. Ferrum (tn)

    46. Iron (as Fumarate)

    47. Meterfer

    48. Iron (as Ferrous Fumarate)

    49. Schembl24284

    50. Schembl24286

    51. Ferrous Fumarate (jan/usp)

    52. Ferrous Fumarate [ii]

    53. Ferrous Fumarate [mi]

    54. Ferrous Fumarate [fcc]

    55. Ferrous Fumarate [jan]

    56. Ferrous Fumarate [inci]

    57. Dtxsid7047148

    58. Ferrous Fumarate [vandf]

    59. Chebi:31607

    60. Amy8976

    61. Ferrous Fumarate [mart.]

    62. Ferrous Fumarate [who-dd]

    63. Ferrous Fumarate [who-ip]

    64. Hy-b1651

    65. Einecs 231-731-5

    66. Mfcd00058315

    67. Akos015918237

    68. Ferrous Fumarate [orange Book]

    69. Db14491

    70. Ferrosi Fumaras [who-ip Latin]

    71. Ferrous Fumarate [ep Monograph]

    72. Ferrous Fumarate [usp Monograph]

    73. Iron (as Ferrous Fumarate) [vandf]

    74. 2-butenedioic Acid (2e)-, Iron(2+) Salt

    75. Cs-0013603

    76. Norquest Fe Component Ferrous Fumarate

    77. D01194

    78. Ferrous Fumarate Component Of Norquest Fe

    79. Lo Minastrin Fe Component Ferrous Fumarate

    80. Minastrin 24 Fe Component Ferrous Fumarate

    81. Q416370

    82. 2-butenedioic Acid (2e)-, Iron(2+) Salt (1:?)

    83. J-007445

    84. J-521364

    85. 7705-12-6

    2.4 Create Date
    2006-04-28
    3 Chemical and Physical Properties
    Molecular Weight 169.90 g/mol
    Molecular Formula C4H2FeO4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count0
    Exact Mass169.930244 g/mol
    Monoisotopic Mass169.930244 g/mol
    Topological Polar Surface Area80.3 Ų
    Heavy Atom Count9
    Formal Charge0
    Complexity108
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFerrous fumarate
    Active IngredientFerrous fumarate
    Dosage FormTablet
    Routeoral
    Strength75mg
    Market StatusTentative Approval
    CompanyBarr Labs

    2 of 2  
    Drug NameFerrous fumarate
    Active IngredientFerrous fumarate
    Dosage FormTablet
    Routeoral
    Strength75mg
    Market StatusTentative Approval
    CompanyBarr Labs

    4.2 Drug Indication

    Used in preventing and treating iron-deficiency anemia.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.

    5.2 MeSH Pharmacological Classification

    Trace Elements

    A group of chemical elements that are needed in minute quantities for the proper growth, development, and physiology of an organism. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) (See all compounds classified as Trace Elements.)

    5.3 ATC Code

    B - Blood and blood forming organs

    B03 - Antianemic preparations

    B03A - Iron preparations

    B03AA - Iron bivalent, oral preparations

    B03AA02 - Ferrous fumarate

    B - Blood and blood forming organs

    B03 - Antianemic preparations

    B03A - Iron preparations

    B03AD - Iron in combination with folic acid

    B03AD02 - Ferrous fumarate

    5.4 Absorption, Distribution and Excretion

    Absorption

    The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Those who are iron deficient may absorb up to 95% of an iron dose.

    5.5 Mechanism of Action

    Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.