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    Firocoxib

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 189954-96-9, Equioxx, Previcox, Librens, Ml 1785713, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one
    Molecular Formula
    C17H20O5S
    Molecular Weight
    336.4  g/mol
    InChI Key
    FULAPETWGIGNMT-UHFFFAOYSA-N
    FDA UNII
    Y6V2W4S4WT
    Firocoxib is a cycooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug. It currently approved for veterinary use in dogs and horses under the brand names Equioxx and Previcox. Firocoxib was the first COX-2 inhibitor approved by the U.S. Food and Drug Administration for horses. Firocoxib is not intended or approved for use in human medicine.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
    2.1.2 InChI
    InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
    2.1.3 InChI Key
    FULAPETWGIGNMT-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1(C(=C(C(=O)O1)OCC2CC2)C3=CC=C(C=C3)S(=O)(=O)C)C
    2.2 Other Identifiers
    2.2.1 UNII
    Y6V2W4S4WT
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

    2. Equioxx

    3. Ml 1,785,713

    4. Ml 1785713

    5. Ml-1,785,713

    6. Ml-1785713

    7. Ml1,785,713

    8. Ml1785713

    2.3.2 Depositor-Supplied Synonyms

    1. 189954-96-9

    2. Equioxx

    3. Previcox

    4. Librens

    5. Ml 1785713

    6. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)furan-2(5h)-one

    7. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one

    8. Ml-1,785,713

    9. Nsc-758895

    10. Y6v2w4s4wt

    11. Chembl69998

    12. Chebi:76136

    13. Firocoxib (ema Epar: Veterinary)

    14. Equixx

    15. Ml-1785713

    16. 3-(cyclopropylmethoxy)-4-(4-methylsulfonylphenyl)-5,5-dimethylfuranone

    17. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-(methylsulfonyl)phenyl)-

    18. 2(5h)-furanone, 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-

    19. 3-(cyclopropylmethoxy)-4-(4-methanesulfonylphenyl)-5,5-dimethyl-2,5-dihydrofuran-2-one

    20. Firocoxib [usan:inn]

    21. Unii-y6v2w4s4wt

    22. Firocoxibum

    23. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]-2(5h)-furanone

    24. 3-(cyclopropylmethoxy)-5,5-dimethyl-4-[4-(methylsulfonyl)phenyl]furan-2(5h)-one

    25. Firocoxib [inn]

    26. Firocoxib [mi]

    27. Firocoxib (usan/inn)

    28. Firocoxib [usan]

    29. Firocoxib [mart.]

    30. Equioxx (tn) [veterinary]

    31. Firocoxib [green Book]

    32. Amy378

    33. Schembl1383179

    34. Dtxsid40870188

    35. Hms3264g15

    36. Pharmakon1600-01504526

    37. Bcp07253

    38. Zinc3623447

    39. Bdbm50080082

    40. Nsc758895

    41. Ccg-213396

    42. Cs-3419

    43. Db09217

    44. Nsc 758895

    45. Ncgc00389572-01

    46. Ncgc00389572-02

    47. Ac-33540

    48. As-73802

    49. Hy-14670

    50. Sbi-0206717.p001

    51. Ft-0668544

    52. Firocoxib, Vetranal(tm), Analytical Standard

    53. C18363

    54. C73637

    55. D03712

    56. Ab01563063_01

    57. 954f969

    58. A918990

    59. Sr-01000872758

    60. J-012265

    61. Q2034390

    62. Sr-01000872758-1

    63. 3-(cyclopropylmethoxy)-4-(4-methylsulfonyl)phenyl)-5,5-dimethylfuranone

    64. 3-(cyclopropylmethoxy)-4-[4-(methanesulfonyl)phenyl]-5,5-dimethylfuran-2(5h)-one

    65. 3-cyclopropylmethoxy-4-(4-methanesulfonyl-phenyl)-5,5-dimethyl-5h-furan-2-one

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 336.4 g/mol
    Molecular Formula C17H20O5S
    XLogP32.2
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count5
    Exact Mass336.10314491 g/mol
    Monoisotopic Mass336.10314491 g/mol
    Topological Polar Surface Area78 Ų
    Heavy Atom Count23
    Formal Charge0
    Complexity614
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Used for the treatment of pain inflammation and fever in horses and dogs.

    * Tablets:

    For the relief of pain and inflammation associated with osteoarthritis in dogs.

    For the relief of postoperative pain and inflammation associated with soft-tissue, orthopaedic and dental surgery in dogs.

    * Oral paste:

    Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.

    Alleviation of pain and inflammation associated with osteoarthritis and reduction of associated lameness in horses.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    QM01AH90

    QM01AH90