![Minakem Generic APIs](https://www.pharmacompass.com/image/flap/minakem-header-desktop-w27gif-57924.gif)
![Minakem Generic APIs](https://www.pharmacompass.com/image/flap/minakem-header-mobile-w27gif-62411.gif)
1. 18f-bay94-9172
2. 18f-florbetaben
3. 4-(n-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
4. Bay 94-9172
5. Bay94 9172
6. Bay94-9172
7. Florbetaben
1. Neuraceq
2. Florbetaben (18f)
3. Florbetaben F18
4. Florbetaben
5. Florbetaben F 18
6. 18f-florbetaben
7. Unii-tla7312toi
8. 902143-01-5
9. Florbetaben ((sup 18)f)
10. Florbetaben (18f) [inn]
11. Bay94-9172
12. Bay 94-9172
13. Chebi:79033
14. Florbetaben F18 [usan]
15. Bay-949172
16. 18f-bay94-9172
17. Tla7312toi
18. Av-1
19. 4-((1e)-2-(4-(2-(2-(2-((sup 18(f))fluoroethoxy)ethoxy)ethoxy)phenyl)eth-1-en-1-yl)-n-methylaniline
20. 4-[(e)-2-[4-[2-[2-(2-(18f)fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-n-methylaniline
21. Neuraceq (tn)
22. Florbetaben ((18)f)
23. Florbetaben 18f [inn]
24. Florbetaben (f-18)
25. Chembl566752
26. Gtpl7769
27. Schembl11301755
28. Florbetaben F 18 [mi]
29. Dtxsid20238065
30. Florbetaben(18f) [jan]
31. Bdbm50485236
32. Florbetaben (18f) [who-dd]
33. Bay94 9172
34. Db09148
35. Florbetaben (18f) (jan/usan/inn)
36. Florbetaben F-18 [orange Book]
37. [18f]bay 94-9172
38. Zk-6013443
39. Q17014149
40. 4-[(e)-2-[4-[2-[2-(2-fluoranylethoxy)ethoxy]ethoxy]phenyl]ethenyl]-n-methylaniline
41. 4-{(e)-2-[4-(2-{2-[2-((18)f)fluoroethoxy]ethoxy}ethoxy)phenyl]ethenyl}-n-methylaniline
Molecular Weight | 358.4 g/mol |
---|---|
Molecular Formula | C21H26FNO3 |
XLogP3 | 4.2 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 5 |
Rotatable Bond Count | 12 |
Exact Mass | 358.192206 g/mol |
Monoisotopic Mass | 358.192206 g/mol |
Topological Polar Surface Area | 39.7 Ų |
Heavy Atom Count | 26 |
Formal Charge | 0 |
Complexity | 364 |
Isotope Atom Count | 1 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 1 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Florbetaben is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the brain to estimate -amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimers Disease (AD) and other causes of cognitive decline.
FDA Label
This medicinal product is for diagnostic use only.
Neuraceq is a radiopharmaceutical indicated for Positron Emission Tomography (PET) imaging of amyloid neuritic plaque density in the brains of adult patients with cognitive impairment who are being evaluated for Alzheimers disease (AD) and other causes of cognitive impairment. Neuraceq should be used in conjunction with a clinical evaluation.
A negative scan indicates sparse or no plaques, which is not consistent with a diagnosis of AD.
Following intravenous administration, Neuraceq crosses the blood brain barrier and shows differential retention in brain regions that contain -amyloid deposits. Differences in signal intensity between brain regions showing specific and non-specific Neuraceq uptake form the basis for the image interpretation method.
V09AX06
V - Various
V09 - Diagnostic radiopharmaceuticals
V09A - Central nervous system
V09AX - Other central nervous system diagnostic radiopharmaceuticals
V09AX06 - Florbetaben (18F)
Absorption
Ten minutes after intravenous bolus injection of 300 MBq of Neuraceq in human volunteers, approximately 6% of the injected radioactivity was distributed to the brain. Florbetaben F 18 plasma concentrations declined by approximately 75% at 20 minutes post-injection, and by approximately 90% at 50 minutes.
Route of Elimination
At 12 hours post-administration, approximately 30% of the injected radioactivity had been excreted in urine.
In vitro studies show that metabolism of florbetaben is predominantly catalyzed by CYP2J2 and CYP4F2. Almost all F18 radioactivity in urine was excreted as polar metabolites of florbetaben F18 and only trace amounts of florbetaben F18 were detected.
1 hr
Florbetaben F18 is a F18-labeled stilbene derivative, which binds to -amyloid plaques in the brain. The F 18 isotope produces a positron signal that is detected by a PET scanner.