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    Flumethasone Pivalate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

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    2D Structure
    Also known as: Locorten, 2002-29-1, Locacorten, Flumetasone pivalate, Flumethasone 21-pivalate, Lorinden
    Molecular Formula
    C27H36F2O6
    Molecular Weight
    494.6  g/mol
    InChI Key
    JWRMHDSINXPDHB-OJAGFMMFSA-N
    FDA UNII
    0DV09X6F21
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate
    2.1.2 InChI
    InChI=1S/C27H36F2O6/c1-14-9-16-17-11-19(28)18-10-15(30)7-8-24(18,5)26(17,29)20(31)12-25(16,6)27(14,34)21(32)13-35-22(33)23(2,3)4/h7-8,10,14,16-17,19-20,31,34H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,24+,25+,26+,27+/m1/s1
    2.1.3 InChI Key
    JWRMHDSINXPDHB-OJAGFMMFSA-N
    2.1.4 Canonical SMILES
    CC1CC2C3CC(C4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F
    2.1.5 Isomeric SMILES
    C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)COC(=O)C(C)(C)C)O)C)O)F)C)F
    2.2 Other Identifiers
    2.2.1 UNII
    0DV09X6F21
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cerson

    2. Flumethasone Dimethylpropionate

    3. Locacorten

    4. Locorten

    2.3.2 Depositor-Supplied Synonyms

    1. Locorten

    2. 2002-29-1

    3. Locacorten

    4. Flumetasone Pivalate

    5. Flumethasone 21-pivalate

    6. Lorinden

    7. Nsc 107680

    8. Nsc-107680

    9. Mls000069558

    10. Mls001077304

    11. Chebi:31620

    12. 0dv09x6f21

    13. Nsc107680

    14. Smr000058824

    15. Flumethasone-21-pivalate

    16. Locorten (tn)

    17. 6.alpha.,9-difluoro-11.beta.,17,21-trihydroxy-16.alpha.-methylpregna-1,4-diene-3,20-dione 21-pivalate

    18. Flumetasone 21-pivalate

    19. Flumethasone Pivalate (usp)

    20. Unii-0dv09x6f21

    21. 6.alpha.,9.alpha.-difluoro-16.alpha.-methylprednisolone 21-pivalate

    22. Flumetasone Pivalate (jan/ban)

    23. Flumethasone Pivalate [usan:usp]

    24. Ncgc00022408-03

    25. Flumethsone Pivalate

    26. Einecs 217-901-1

    27. Flumethasone-pivalate

    28. Flumethasome Pivalate

    29. Ks-1138

    30. Opera_id_1461

    31. Schembl6968

    32. [2-[(6s,8s,9r,10s,11s,13s,14s,16r,17r)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate

    33. Gtpl7075

    34. Chembl1200877

    35. 6alpha,9alpha-difluoro-16alpha-methylprednisolone 21-pivalate

    36. Flumetasone Pivalate [jan]

    37. Hms2231d24

    38. Hms3715l14

    39. Zinc3977985

    40. Flumethasone Pivalate [usan]

    41. Flumetasone Pivalate [mart.]

    42. Flumetasone Pivalate [who-dd]

    43. Akos015964841

    44. Ac-2070

    45. Ccg-221256

    46. Flumethasone 21-pivalate [mi]

    47. 6,9-difluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl Pivalate

    48. Ncgc00022408-04

    49. 6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate)

    50. 6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate

    51. 6alpha,9-difluoro-11beta,17-dihydroxy-16alpha-methyl-3,20-dioxopregna-1,4-dien-21-yl 2,2-dimethylpropanoate

    52. Flumetasone Pivalate [ep Monograph]

    53. Flumethasone Pivalate [orange Book]

    54. Flumethasone Pivalate [usp Impurity]

    55. D01464

    56. E98632

    57. 002f291

    58. Q-101376

    59. Q20817117

    60. Flumethasone Pivalate, British Pharmacopoeia (bp) Reference Standard

    61. Flumethasone Pivalate, European Pharmacopoeia (ep) Reference Standard

    62. Flumethasone Pivalate, United States Pharmacopeia (usp) Reference Standard

    63. [2-[(6s,8s,9r,10s,11s,13s,14s,16r,17r)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] 2,2-dimethylpropanoate

    64. 2-((6s,9r,10s,11s,13s,16r,17r)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3h-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl Pivalate

    65. 2-[(1r,2s,8s,10s,11s,13r,14r,15s,17s)-1,8-difluoro-14,17-dihydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-14-yl]-2-oxoethyl 2,2-dimethylpropanoate

    66. 6alpha,9alpha-difluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, 21-pivalate

    67. Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11, 17-dihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)-

    68. Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)

    69. Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-

    70. Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-, 21-pivalate

    71. Pregna-1,4-diene-3,20-dione, 6alpha,9-difluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 21-pivalate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 494.6 g/mol
    Molecular Formula C27H36F2O6
    XLogP33.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass494.24799519 g/mol
    Monoisotopic Mass494.24799519 g/mol
    Topological Polar Surface Area101 Ų
    Heavy Atom Count35
    Formal Charge0
    Complexity1030
    Isotope Atom Count0
    Defined Atom Stereocenter Count9
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)