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    Flupentixol Dihydrochloride

    ACTIVE PHARMA INGREDIENTS

    INTERMEDIATES

    FINISHED DOSAGE FORMULATIONS

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    REF. STANDARDS & IMPURITIES

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    $ API Ref.Price (USD/KG) : 1,526Xls

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    2D Structure
    Also known as: 51529-01-2, Flupenthixol dihydrochloride, Emergil, Cis-(z)-flupenthixol dihydrochloride, 2413-38-9, Flupentixol hcl
    Molecular Formula
    C23H27Cl2F3N2OS
    Molecular Weight
    507.4  g/mol
    InChI Key
    IOVDQEIIMOZNNA-MHKBYHAFSA-N
    FDA UNII
    96L0Z069N1
    A thioxanthene neuroleptic that, unlike CHLORPROMAZINE, is claimed to have CNS-activating properties. It is used in the treatment of psychoses although not in excited or manic patients. (From Martindale, The Extra Pharmacopoeia, 30th ed, p595)
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[4-[(3Z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol;dihydrochloride
    2.1.2 InChI
    InChI=1S/C23H25F3N2OS.2ClH/c24-23(25,26)17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)30-22)5-3-9-27-10-12-28(13-11-27)14-15-29;;/h1-2,4-8,16,29H,3,9-15H2;2*1H/b18-5-;;
    2.1.3 InChI Key
    IOVDQEIIMOZNNA-MHKBYHAFSA-N
    2.1.4 Canonical SMILES
    C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
    2.1.5 Isomeric SMILES
    C1CN(CCN1CC/C=C\2/C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F)CCO.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    96L0Z069N1
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Alpha-flupenthixol

    2. Cis-flupenthixol

    3. Emergil

    4. Fluanxol

    5. Flupenthixol

    6. Flupentixol

    2.3.2 Depositor-Supplied Synonyms

    1. 51529-01-2

    2. Flupenthixol Dihydrochloride

    3. Emergil

    4. Cis-(z)-flupenthixol Dihydrochloride

    5. 2413-38-9

    6. Flupentixol Hcl

    7. Cis-(z)-flupentixol Dihydrochloride

    8. Fupentixol Dihydrochloride

    9. (z)-flupenthixol Dihydrochloride

    10. Flupenthixol 2hcl

    11. (e/z)-flupentixol Dihydrochloride

    12. Flupenthixol, Dihydrochloride

    13. Fx 703

    14. Flupentixol Dihydrochloride Cis-(z)

    15. 96l0z069n1

    16. Cis-(z)-flupentixol (dihydrochloride)

    17. Flupentixol Hydrochloride

    18. (z)-4-[3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Dihydrochloride

    19. 2-[4-[(3z)-3-[2-(trifluoromethyl)thioxanthen-9-ylidene]propyl]piperazin-1-yl]ethanol;dihydrochloride

    20. N 7009

    21. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Dihydrochloride, (z)-

    22. (z)-4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-1-piperazineethanol Dihydrochloride

    23. Einecs 219-321-4

    24. Nsc 170952

    25. Unii-96l0z069n1

    26. Prestwick_902

    27. Cis-flupenthixol 2hcl

    28. Unii-hat84mlq6z

    29. Hat84mlq6z

    30. 1-piperazineethanol, 4-(3-(2-trifluoromethylthioxanth-9-ylidene)propyl)-, Dihydrochloride

    31. 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-1-piperazineethanol Dihydrochloride

    32. Cis-flupenthixol Hydrochloride

    33. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Dihydrochloride

    34. Cis-flupenthixol Dihydrochloride

    35. (z)-flupentixol Dihydrochloride

    36. Schembl1153162

    37. Chembl1496351

    38. Ex-a352

    39. Chebi:180489

    40. Flupentixol Dihydrochloride (jan)

    41. Cis-(z)-flupentixoldihydrochloride

    42. Dtxsid501017247

    43. Hms1569c21

    44. Cis(z)-flupentixol Dihydrochloride

    45. 4-[3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Dihydrochloride

    46. Cis-flupentixol Hydrochloride

    47. Tox21_500528

    48. Mfcd00069278

    49. S3664

    50. Akos025401529

    51. Ac-2136

    52. Ccg-221832

    53. Lp00528

    54. 1-piperazineethanol, 4-(3-(2-(trifluoromethyl)thioxanthen-9-ylidene)propyl)-, Dihydrochloride

    55. Ncgc00093921-01

    56. Ncgc00261213-01

    57. .alpha.-flupenthixol Hydrochloride

    58. 4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)piperazine-1-ethanol Dihydrochloride

    59. Bs-16961

    60. Flupentixol Dihydrochloride, (z)-

    61. Hy-15856

    62. Thioxanthene, 9-(3-(4-(2-hydroxyethyl)piperazinyl)propylidene)-2-trifluoromethyl-, Dihydrochloride

    63. B7578

    64. Cs-0009393

    65. Eu-0100528

    66. F-114

    67. D02236

    68. 529f012

    69. Sr-01000076232

    70. J-015359

    71. Sr-01000076232-1

    72. Q27271910

    73. Cis-(z)-flupenthixol Dihydrochloride, >=98% (hplc), Solid

    74. (z)-2-(4-(3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethanol Dihydrochloride

    75. (z)-4-[3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazine-ethanol Dihydrochloride

    76. 1-(2-hydroxyethyl)-4-{(3z)-3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl}piperazinediium Dichloride

    77. 1-piperazineethanol, 4-((3z)-3-(2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Dihydrochloride

    78. 1-piperazineethanol, 4-(3-((3z)-2-(trifluoromethyl)-9h-thioxanthen-9-ylidene)propyl)-, Hydrochloride (1:2)

    79. 2-(4-{(3z)-3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethan-1-ol--hydrogen Chloride (1/2)

    80. 2-(4-{(3z)-3-[2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl}piperazin-1-yl)ethanol Dihydrochloride

    81. 4-[3-[(3z)-2-(trifluoromethyl)-9h-thioxanthen-9-ylidene]propyl]-1-piperazineethanol Hydrochloride

    2.4 Create Date
    2005-10-11
    3 Chemical and Physical Properties
    Molecular Weight 507.4 g/mol
    Molecular Formula C23H27Cl2F3N2OS
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count5
    Exact Mass506.1173245 g/mol
    Monoisotopic Mass506.1173245 g/mol
    Topological Polar Surface Area52 Ų
    Heavy Atom Count32
    Formal Charge0
    Complexity592
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count1
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    Dopamine Antagonists

    Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)