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    Fluphenazine Decanoate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: 5002-47-1, Modecate, Fluphenazine depot, Moditen depot, Dapotum d, Lyogen
    Molecular Formula
    C32H44F3N3O2S
    Molecular Weight
    591.8  g/mol
    InChI Key
    VIQCGTZFEYDQMR-UHFFFAOYSA-N
    FDA UNII
    FMU62K1L3C
    Fluphenazine Decanoate is the decanoate salt form of fluphenazine, a phenothiazine with antipsychotic activity. Fluphenazine decanoate exerts its actions by blocking postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia. This prevents the actions of dopamine, thereby reducing the hallucinations and delusions that are associated with schizophrenia.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl decanoate
    2.1.2 InChI
    InChI=1S/C32H44F3N3O2S/c1-2-3-4-5-6-7-8-14-31(39)40-24-23-37-21-19-36(20-22-37)17-11-18-38-27-12-9-10-13-29(27)41-30-16-15-26(25-28(30)38)32(33,34)35/h9-10,12-13,15-16,25H,2-8,11,14,17-24H2,1H3
    2.1.3 InChI Key
    VIQCGTZFEYDQMR-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCCCCCCC(=O)OCCN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F
    2.2 Other Identifiers
    2.2.1 UNII
    FMU62K1L3C
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Fluphenazine Depot

    2. Ftorphenazine Decanoate

    3. Liogen

    4. Mirenil

    5. Modecate

    6. Moditen Depot

    7. Moditen-depot

    2.3.2 Depositor-Supplied Synonyms

    1. 5002-47-1

    2. Modecate

    3. Fluphenazine Depot

    4. Moditen Depot

    5. Dapotum D

    6. Lyogen

    7. Prolixin Decanoate

    8. Flufenazine Decanoate

    9. Fluorophenazine Decanoate

    10. Fluphenazine O-decanoate

    11. Fluphenaline Decanoate

    12. Sq 10,733

    13. 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl Decanoate

    14. 2-(4-{3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl}piperazin-1-yl)ethyl Decanoate

    15. Nsc-169510

    16. Fmu62k1l3c

    17. 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Decanoate

    18. Decanoic Acid, 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Ester

    19. Decanoic Acid, 2-[4-[3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl Ester

    20. Qd-10733

    21. Sq-10733

    22. 2-(4-(3-(2-(trifluoromethyl)-10h-phenothiazin-10-yl)propyl)piperazin-1-yl)ethyl Decanoate

    23. Decanoic Acid, 2-(4-(3-(2-(trifluoromethyl)phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Ester

    24. Decanoic Acid, 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl Ester

    25. Moditen-depo

    26. Fluphenazinedecanoate

    27. Ccris 3954

    28. Prolixin Decanoate (tn)

    29. Einecs 225-672-4

    30. Unii-fmu62k1l3c

    31. Nsc 169510

    32. Brn 0599852

    33. Dapotum Depot

    34. Fluphenazine Decanoate (jan/usp)

    35. Anatensol Decanoate

    36. Fluphenazini Decanoas

    37. Depot

    38. Fluphenazine-decanoate

    39. Fluphenazine Decanoate [usp:ban:jan]

    40. Schembl41288

    41. Mls006010097

    42. Chebi:5124

    43. Chembl1200854

    44. Dtxsid7023069

    45. Fluphenazine Decanoate [mi]

    46. Bcp18078

    47. Hy-b1904

    48. Fluphenazine Decanoate [jan]

    49. Mfcd00798504

    50. Nsc169510

    51. Zinc22816725

    52. Fluphenazine Decanoate [vandf]

    53. Akos003589045

    54. Fluphenazine Decanoate [mart.]

    55. Fluphenazine Decanoate [who-dd]

    56. Fluphenazine Decanoate [who-ip]

    57. Ncgc00386699-01

    58. As-11646

    59. Smr004701239

    60. Fluphenazine Decanoate [orange Book]

    61. Cs-0013962

    62. Fluphenazine Decanoate [ep Monograph]

    63. Fluphenazine Decanoate [usp Impurity]

    64. Fluphenazini Decanoas [who-ip Latin]

    65. Fluphenazine Decanoate [usp Monograph]

    66. C07956

    67. D00793

    68. 002f471

    69. A827938

    70. Fluphenazine Enanthate Impurity C [ep Impurity]

    71. Q27278080

    72. Wln: T C666 Bn Isj Exfff B3- At6n Dntj D2ov9

    73. Decanoic Acid, 2-(4-(3-(2-(trifluoromethyl)-10h-decanoate Phenothiazin-10-yl)propyl)-1-piperazinyl)ethyl Ester

    74. Decanoic Acid, 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazinyl]ethyl Ester (7ci,8ci)

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 591.8 g/mol
    Molecular Formula C32H44F3N3O2S
    XLogP39
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count9
    Rotatable Bond Count16
    Exact Mass591.31063331 g/mol
    Monoisotopic Mass591.31063331 g/mol
    Topological Polar Surface Area61.3 Ų
    Heavy Atom Count41
    Formal Charge0
    Complexity765
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFluphenazine decanoate
    Drug LabelFluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect and has the following structural formula:Fluphenazine Decanoate Injection...
    Active IngredientFluphenazine decanoate
    Dosage FormInjectable
    RouteInjection
    Strength25mg/ml
    Market StatusPrescription
    CompanyPar Sterile Products; Fresenius Kabi Usa; Eurohlth Intl

    2 of 2  
    Drug NameFluphenazine decanoate
    Drug LabelFluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect and has the following structural formula:Fluphenazine Decanoate Injection...
    Active IngredientFluphenazine decanoate
    Dosage FormInjectable
    RouteInjection
    Strength25mg/ml
    Market StatusPrescription
    CompanyPar Sterile Products; Fresenius Kabi Usa; Eurohlth Intl

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antipsychotic Agents

    Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Phenothiazines [CS]; Phenothiazine [EPC]