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    Fluprednidene Acetate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    GLOBAL SALES INFORMATION

    MARKET PLACE

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Decoderm, 1255-35-2, 9-fluoro-11beta,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione 21-acetate, Ge65dv564s, Emecort, Fluprednidene 21-acetate
    Molecular Formula
    C24H29FO6
    Molecular Weight
    432.5  g/mol
    InChI Key
    DEFOZIFYUBUHHU-IYQKUMFPSA-N
    FDA UNII
    GE65DV564S
    Fluprednidene acetate is a corticosteroid. It has anti-inflammatory and anti-allergic properties.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    [2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylidene-3-oxo-7,8,11,12,14,15-hexahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
    2.1.2 InChI
    InChI=1S/C24H29FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,17-19,28,30H,1,5-6,9,11-12H2,2-4H3/t17-,18-,19-,21-,22-,23-,24-/m0/s1
    2.1.3 InChI Key
    DEFOZIFYUBUHHU-IYQKUMFPSA-N
    2.1.4 Canonical SMILES
    CC(=O)OCC(=O)C1(C(=C)CC2C1(CC(C3(C2CCC4=CC(=O)C=CC43C)F)O)C)O
    2.1.5 Isomeric SMILES
    CC(=O)OCC(=O)[C@]1(C(=C)C[C@@H]2[C@@]1(C[C@@H]([C@]3([C@H]2CCC4=CC(=O)C=C[C@@]43C)F)O)C)O
    2.2 Other Identifiers
    2.2.1 UNII
    GE65DV564S
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Decoderm

    2. Fluprednylidene Acetate

    2.3.2 Depositor-Supplied Synonyms

    1. Decoderm

    2. 1255-35-2

    3. 9-fluoro-11beta,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione 21-acetate

    4. Ge65dv564s

    5. Emecort

    6. Fluprednidene 21-acetate

    7. Unii-ge65dv564s

    8. Decoderm (tn)

    9. Einecs 215-013-9

    10. Schembl7333

    11. Chebi:135700

    12. Fluprednidene Acetate [mi]

    13. Zinc30691649

    14. Fluprednidene Acetate [mart.]

    15. Fluprednidene Acetate [who-dd]

    16. Db14634

    17. [2-[(8s,9r,10s,11s,13s,14s,17r)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-16-methylidene-3-oxo-7,8,11,12,14,15-hexahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] Acetate

    18. D07980

    19. J-005237

    20. 9-fluoro-11beta,17,21-trihydroxy-16-methylenepregna-1,4-diene-3,20-dione21-acetate

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 432.5 g/mol
    Molecular Formula C24H29FO6
    XLogP32.3
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count4
    Exact Mass432.19481680 g/mol
    Monoisotopic Mass432.19481680 g/mol
    Topological Polar Surface Area101 Ų
    Heavy Atom Count31
    Formal Charge0
    Complexity952
    Isotope Atom Count0
    Defined Atom Stereocenter Count7
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Glucocorticoids

    A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (See all compounds classified as Glucocorticoids.)