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2D Structure
Also known as: Flurazepam dihydrochloride, 1172-18-5, Dalmane, Dalmadorm, Dalmate, Felison
Molecular Formula
C21H25Cl3FN3O
Molecular Weight
460.8  g/mol
InChI Key
ZIIJJOPLRSCQNX-UHFFFAOYSA-N
FDA UNII
756RDM536M

A benzodiazepine derivative used mainly as a hypnotic.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;dihydrochloride
2.1.2 InChI
InChI=1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H
2.1.3 InChI Key
ZIIJJOPLRSCQNX-UHFFFAOYSA-N
2.1.4 Canonical SMILES
CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl
2.2 Other Identifiers
2.2.1 UNII
756RDM536M
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Apo Flurazepam

2. Apo-flurazepam

3. Dalmadorm

4. Dalmane

5. Dihydrochloride, Flurazepam

6. Dormodor

7. Flurazepam

8. Flurazepam Dihydrochloride

9. Flurazepam Mono Perchlorate

10. Flurazepam Mono-perchlorate

11. Flurazepam Monohydrochloride

12. Hydrochloride, Flurazepam

13. Mono-perchlorate, Flurazepam

14. Monohydrochloride, Flurazepam

15. Staurodorm

2.3.2 Depositor-Supplied Synonyms

1. Flurazepam Dihydrochloride

2. 1172-18-5

3. Dalmane

4. Dalmadorm

5. Dalmate

6. Felison

7. Linzac

8. Natam

9. Nsc-78559

10. Ro 5-6901

11. Insumin Dihydrochloride

12. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Dihydrochloride

13. Flurazepam Hydrochloride Civ

14. Id 480

15. 756rdm536m

16. 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one Dihydrochloride

17. Ro-5-6901

18. Benozil

19. Lunipax

20. Somlan

21. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3h-1,4-benzodiazepin-2-one;dihydrochloride

22. Dea No. 2767

23. Einecs 214-630-0

24. Unii-756rdm536m

25. Dalmane (tn)

26. Flurazepam Hydrochloride [usan:usp:jan]

27. Schembl29792

28. Chebi:5129

29. Flurazepam Hydrochloride (usp)

30. Chembl3989724

31. Dtxsid3025334

32. Flurazepam Dihydrochloride, Solid

33. Flurazepam Hydrochloride [jan]

34. Flurazepam Dihydrochloride [mi]

35. Flurazepam Hydrochloride [usan]

36. Flurazepam Hydrochloride [vandf]

37. Flurazepam Hydrochloride [who-dd]

38. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, Dihydrochloride

39. Flurazepam Dihydrochloride [mart.]

40. Db-041356

41. Flurazepam Hydrochloride Civ [usp-rs]

42. Flurazepam Hydrochloride [orange Book]

43. D00695

44. Flurazepam Hydrochloride [usp Monograph]

45. W-108568

46. Q27266355

47. Flurazepam Dihydrochloride, Drug Standard, 1.0 Mg/ml In Methanol

48. Flurazepam Hydrochloride, United States Pharmacopeia (usp) Reference Standard

49. 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one, Dihydrochloride

2.4 Create Date
2005-06-24
3 Chemical and Physical Properties
Molecular Weight 460.8 g/mol
Molecular Formula C21H25Cl3FN3O
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass459.104724 g/mol
Monoisotopic Mass459.104724 g/mol
Topological Polar Surface Area35.9 Ų
Heavy Atom Count29
Formal Charge0
Complexity540
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Information
1 of 2  
Drug NameFlurazepam hydrochloride
Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active IngredientFlurazepam hydrochloride
Dosage FormCapsule
RouteOral
Strength30mg; 15mg
Market StatusPrescription
CompanyMylan Pharms

2 of 2  
Drug NameFlurazepam hydrochloride
Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
Active IngredientFlurazepam hydrochloride
Dosage FormCapsule
RouteOral
Strength30mg; 15mg
Market StatusPrescription
CompanyMylan Pharms

5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Anti-Anxiety Agents

Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)


GABA Modulators

Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)


Hypnotics and Sedatives

Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Benzodiazepines [CS]; Benzodiazepine [EPC]