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    Flurazepam Dihydrochloride

    ACTIVE PHARMA INGREDIENTS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Flurazepam dihydrochloride, 1172-18-5, Dalmane, Dalmadorm, Dalmate, Felison
    Molecular Formula
    C21H25Cl3FN3O
    Molecular Weight
    460.8  g/mol
    InChI Key
    ZIIJJOPLRSCQNX-UHFFFAOYSA-N
    FDA UNII
    756RDM536M
    A benzodiazepine derivative used mainly as a hypnotic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one;dihydrochloride
    2.1.2 InChI
    InChI=1S/C21H23ClFN3O.2ClH/c1-3-25(4-2)11-12-26-19-10-9-15(22)13-17(19)21(24-14-20(26)27)16-7-5-6-8-18(16)23;;/h5-10,13H,3-4,11-12,14H2,1-2H3;2*1H
    2.1.3 InChI Key
    ZIIJJOPLRSCQNX-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    756RDM536M
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Apo Flurazepam

    2. Apo-flurazepam

    3. Dalmadorm

    4. Dalmane

    5. Dihydrochloride, Flurazepam

    6. Dormodor

    7. Flurazepam

    8. Flurazepam Dihydrochloride

    9. Flurazepam Mono Perchlorate

    10. Flurazepam Mono-perchlorate

    11. Flurazepam Monohydrochloride

    12. Hydrochloride, Flurazepam

    13. Mono-perchlorate, Flurazepam

    14. Monohydrochloride, Flurazepam

    15. Staurodorm

    2.3.2 Depositor-Supplied Synonyms

    1. Flurazepam Dihydrochloride

    2. 1172-18-5

    3. Dalmane

    4. Dalmadorm

    5. Dalmate

    6. Felison

    7. Linzac

    8. Natam

    9. Nsc-78559

    10. Ro 5-6901

    11. Insumin Dihydrochloride

    12. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-, Dihydrochloride

    13. Flurazepam Hydrochloride Civ

    14. Id 480

    15. 756rdm536m

    16. 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one Dihydrochloride

    17. Ro-5-6901

    18. Benozil

    19. Lunipax

    20. Somlan

    21. 7-chloro-1-[2-(diethylamino)ethyl]-5-(2-fluorophenyl)-3h-1,4-benzodiazepin-2-one;dihydrochloride

    22. Dea No. 2767

    23. Einecs 214-630-0

    24. Unii-756rdm536m

    25. Dalmane (tn)

    26. Flurazepam Hydrochloride [usan:usp:jan]

    27. Schembl29792

    28. Chebi:5129

    29. Flurazepam Hydrochloride (usp)

    30. Chembl3989724

    31. Dtxsid3025334

    32. Flurazepam Dihydrochloride, Solid

    33. Flurazepam Hydrochloride [jan]

    34. Flurazepam Dihydrochloride [mi]

    35. Flurazepam Hydrochloride [usan]

    36. Flurazepam Hydrochloride [vandf]

    37. Flurazepam Hydrochloride [who-dd]

    38. 2h-1,4-benzodiazepin-2-one, 7-chloro-1-(2-(diethylamino)ethyl)-5-(o-fluorophenyl)-, 1,3-dihydro-, Dihydrochloride

    39. Flurazepam Dihydrochloride [mart.]

    40. Db-041356

    41. Flurazepam Hydrochloride Civ [usp-rs]

    42. Flurazepam Hydrochloride [orange Book]

    43. D00695

    44. Flurazepam Hydrochloride [usp Monograph]

    45. W-108568

    46. Q27266355

    47. Flurazepam Dihydrochloride, Drug Standard, 1.0 Mg/ml In Methanol

    48. Flurazepam Hydrochloride, United States Pharmacopeia (usp) Reference Standard

    49. 7-chloro-1-(2-(diethylamino)ethyl)-5-(2-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one, Dihydrochloride

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 460.8 g/mol
    Molecular Formula C21H25Cl3FN3O
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count6
    Exact Mass459.104724 g/mol
    Monoisotopic Mass459.104724 g/mol
    Topological Polar Surface Area35.9 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity540
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameFlurazepam hydrochloride
    Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
    Active IngredientFlurazepam hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength30mg; 15mg
    Market StatusPrescription
    CompanyMylan Pharms

    2 of 2  
    Drug NameFlurazepam hydrochloride
    Drug LabelFlurazepam hydrochloride is chemically 7-chloro-1-[2-(diethylamino)ethyl]-5-(o-fluoro-phenyl)-1,3dihydro-2H-1,4-benzodiazepin-2-one dihydrochloride. It is a pale yellow, crystalline compound, freely soluble in alcohol and very soluble in water. It ha...
    Active IngredientFlurazepam hydrochloride
    Dosage FormCapsule
    RouteOral
    Strength30mg; 15mg
    Market StatusPrescription
    CompanyMylan Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    GABA Modulators

    Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here. (See all compounds classified as GABA Modulators.)

    Hypnotics and Sedatives

    Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Benzodiazepines [CS]; Benzodiazepine [EPC]