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    Fostamatinib Disodium Hexahydrate

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

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    $ API Ref.Price (USD/KG) : 19,619Xls

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    2D Structure
    Also known as: 1025687-58-4, Fostamatinib disodium, R788 disodium, R788 (fostamatinib) disodium, R 788 sodium, R935788 (fostamatinib disodium, r788)
    Molecular Formula
    C23H24FN6Na2O9P
    Molecular Weight
    624.4  g/mol
    InChI Key
    HSYBQXDGYCYSGA-UHFFFAOYSA-L
    FDA UNII
    X9417132K8
    Fostamatinib Disodium Anhydrous is the anhydrous form of fostamatinib disodium, an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate
    2.1.2 InChI
    InChI=1S/C23H26FN6O9P.2Na/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;/q;2*+1/p-2
    2.1.3 InChI Key
    HSYBQXDGYCYSGA-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    X9417132K8
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4h-pyrido(3,2-b)-1,4-oxazin-4-yl)methyl Disodium Phosphate Hexahydrate

    2. 2h-pyrido(3,2-b)-1,4-oxazin-3(4h)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-

    3. 2h-pyrido(3,2-b)-1,4-oxazin-3(4h)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-, Sodium Salt (1:2)

    4. Fostamatinib

    5. Fostamatinib Disodium

    6. Fostamatinib Disodium Hydrate

    7. Fostamatinib Disodium Salt Hexahydrate

    8. R-788 Free Acid

    9. R-788 Sodium

    10. R-788 Sodium Anhydrous

    11. R-788 Sodium Hydrate

    12. R-935788 Free Acid

    13. R-935788 Sodium Anhydrous

    14. R-935788 Sodium Hydrate

    15. R788 Free Acid

    16. R788 Sodium

    17. R788 Sodium Anhydrous

    18. R788 Sodium Hydrate

    19. R935788 Free Acid

    20. R935788 Sodium Anhydrous

    21. R935788 Sodium Hydrate

    22. Tavalisse

    2.3.2 Depositor-Supplied Synonyms

    1. 1025687-58-4

    2. Fostamatinib Disodium

    3. R788 Disodium

    4. R788 (fostamatinib) Disodium

    5. R 788 Sodium

    6. R935788 (fostamatinib Disodium, R788)

    7. R 935788 Sodium

    8. Tavalisse

    9. Tamatinib Fosdium

    10. X9417132k8

    11. 2h-pyrido(3,2-b)-1,4-oxazin-3(4h)-one, 6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)-4-pyrimidinyl)amino)-2,2-dimethyl-4-((phosphonooxy)methyl)-, Sodium Salt (1:2)

    12. Disodium;[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl Phosphate

    13. R788(fostamatinib Disodium)

    14. Disodium (6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2h-pyrido[3,2-b][1,4]oxazin-4(3h)-yl)methyl Dihydrogen Phosphate

    15. R-935788

    16. Fosd

    17. Fostamatinib Sodium

    18. Unii-x9417132k8

    19. R788(disodium)

    20. R788, Fostamatinib

    21. R788 Disodium (fostamatinib)

    22. R788 Sodium Anhydrous

    23. Schembl3657651

    24. R-788 Sodium Anhydrous

    25. Dtxsid70145275

    26. Ex-a2146

    27. R935788 (fostamatinib Disodium)

    28. R935788 - Fostamatinib Disodium

    29. R935788 Sodium Anhydrous

    30. R-935788 Sodium Anhydrous

    31. Akos026750559

    32. Ccg-270264

    33. Fostamatinib Disodium Salt [mi]

    34. Sb40413

    35. R788(disodium); Fostamatinib Disodium

    36. Ac-28433

    37. As-16263

    38. C71107

    39. J-000725

    40. J-518183

    41. Q27293710

    42. (6-((5-fluoro-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4h-pyrido(3,2-b)-1,4-oxazin-4-yl)methyl Disodium Phosphate

    43. 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2h-pyrido[3,2-b]-1,4-oxazi N-3(4h)-one Sodium Salt

    44. Disodium,[6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxopyrido[3,2-b][1,4]oxazin-4-yl]methyl Phosphate

    2.4 Create Date
    2008-10-27
    3 Chemical and Physical Properties
    Molecular Weight 624.4 g/mol
    Molecular Formula C23H24FN6Na2O9P
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count15
    Rotatable Bond Count9
    Exact Mass624.11218009 g/mol
    Monoisotopic Mass624.11218009 g/mol
    Topological Polar Surface Area192 Ų
    Heavy Atom Count42
    Formal Charge0
    Complexity893
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 1  
    Drug NameTAVALISSE
    Active IngredientFOSTAMATINIB DISODIUM
    CompanyRIGEL PHARMS INC (Application Number: N209299)

    4.2 Drug Indication

    Tavlesse is indicated for the treatment of chronic immune thrombocytopenia (ITP) in adult patients who are refractory to other treatments.

    5 Pharmacology and Biochemistry
    5.1 ATC Code

    B02BX