Please Wait
Applying Filters...
menu
    • menu
    DRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

    Virtual Booth

    Contact Supplier

    Valsynthese, part of the SSE Group, is a CDMO focused on highly energetic and highly hazardous chemistry.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    Bloomage is a one-stop source for CEP Sodium Hyaluronate and Hyaluronic Acid// FDA-inspected & GMP-certified.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2024-10-07

    Virtual Booth

    Contact Supplier

    Menu

    Fruquintinib

    ACTIVE PHARMA INGREDIENTS

    DEVELOPMENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    PATENTS & EXCLUSIVITIES

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: 1194506-26-7, Hmpl-013, Hmpl013, Fruquintinib [who-dd], Fruquintinib(hmpl-013), 6-(6,7-dimethoxyquinazolin-4-yl)oxy-n,2-dimethyl-1-benzofuran-3-carboxamide
    Molecular Formula
    C21H19N3O5
    Molecular Weight
    393.4  g/mol
    InChI Key
    BALLNEJQLSTPIO-UHFFFAOYSA-N
    FDA UNII
    49DXG3M5ZW
    Fruquintinib is an orally available, small molecule inhibitor of vascular endothelial growth factor receptors (VEGFRs), with potential anti-angiogenic and antineoplastic activities. Upon oral administration, fruquintinib inhibits VEGF-induced phosphorylation of VEGFRs 1, 2, and 3 which may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and tumor cell death. Expression of VEGFRs may be upregulated in a variety of tumor cell types.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    6-(6,7-dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
    2.1.2 InChI
    InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
    2.1.3 InChI Key
    BALLNEJQLSTPIO-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C2=C(O1)C=C(C=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(=O)NC
    2.2 Other Identifiers
    2.2.1 UNII
    49DXG3M5ZW
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hmpl-013

    2.3.2 Depositor-Supplied Synonyms

    1. 1194506-26-7

    2. Hmpl-013

    3. Hmpl013

    4. Fruquintinib [who-dd]

    5. Fruquintinib(hmpl-013)

    6. 6-(6,7-dimethoxyquinazolin-4-yl)oxy-n,2-dimethyl-1-benzofuran-3-carboxamide

    7. Fruquintinib [usan]

    8. 49dxg3m5zw

    9. 6-(6,7-dimethoxyquinazolin-4-yloxy)-n,2-dimethylbenzofuran-3-carboxamide

    10. 3-benzofurancarboxamide, 6-((6,7-dimethoxy-4-quinazolinyl)oxy)-n,2-dimethyl-

    11. 6-[(6,7-dimethoxyquinazolin-4-yl)oxy]-n,2-dimethyl-1-benzofuran-3-carboxamide

    12. 6-((6,7-dimethoxyquinazolin-4-yl)oxy)-n,2-dimethylbenzofuran-3-carboxamide

    13. Unii-49dxg3m5zw

    14. Elunate

    15. Fruquintinib [inn]

    16. Fruquintinib; Hmpl-013

    17. Fruquintinib (hmpl-013)

    18. Schembl947183

    19. Gtpl9428

    20. Hmpl 013

    21. Chembl4303214

    22. Bcp15692

    23. Ex-a2262

    24. Nsc801000

    25. Nsc829498

    26. S5667

    27. Who 10348

    28. 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-n,2-dimethyl-3-benzofurancarboxamide

    29. Akos026750586

    30. Zinc114898570

    31. Ccg-268573

    32. Cs-5558

    33. Db11679

    34. Nsc-801000

    35. Nsc-829498

    36. Sb17123

    37. Ncgc00481603-01

    38. As-73141

    39. Hmpl-013;hmpl013;hmpl 013

    40. Hy-19912

    41. B5864

    42. A14393

    43. C71641

    44. A898991

    45. Q27259271

    46. B2693-470819

    2.4 Create Date
    2009-12-15
    3 Chemical and Physical Properties
    Molecular Weight 393.4 g/mol
    Molecular Formula C21H19N3O5
    XLogP33.4
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count5
    Exact Mass393.13247072 g/mol
    Monoisotopic Mass393.13247072 g/mol
    Topological Polar Surface Area95.7 Ų
    Heavy Atom Count29
    Formal Charge0
    Complexity579
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Treatment of colorectal carcinoma