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    Gacyclidine

    DEVELOPMENTS

    PharmaCompass
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    2D Structure
    Also known as: 68134-81-6, Gacyclidine [inn], 1-[(1r,2s)-2-methyl-1-thiophen-2-ylcyclohexyl]piperidine, 1-(cis-2-methyl-1-(2-thienyl)cyclohexyl)piperidine, 9290nd070r, Gk-11
    Molecular Formula
    C16H25NS
    Molecular Weight
    263.4  g/mol
    InChI Key
    DKFAAPPUYWQKKF-GOEBONIOSA-N
    FDA UNII
    9290ND070R
    Gacyclidine has been used in trials studying the treatment of Tinnitus.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[(1R,2S)-2-methyl-1-thiophen-2-ylcyclohexyl]piperidine
    2.1.2 InChI
    InChI=1S/C16H25NS/c1-14-8-3-4-10-16(14,15-9-7-13-18-15)17-11-5-2-6-12-17/h7,9,13-14H,2-6,8,10-12H2,1H3/t14-,16+/m0/s1
    2.1.3 InChI Key
    DKFAAPPUYWQKKF-GOEBONIOSA-N
    2.1.4 Canonical SMILES
    CC1CCCCC1(C2=CC=CS2)N3CCCCC3
    2.1.5 Isomeric SMILES
    C[C@H]1CCCC[C@@]1(C2=CC=CS2)N3CCCCC3
    2.2 Other Identifiers
    2.2.1 UNII
    9290ND070R
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Gk 11

    2. Gk-11

    3. Gk11

    4. Methyl-2-r-(piperidine-1-)-1-(thienyl-2)1-cyclohexene

    2.3.2 Depositor-Supplied Synonyms

    1. 68134-81-6

    2. Gacyclidine [inn]

    3. 1-[(1r,2s)-2-methyl-1-thiophen-2-ylcyclohexyl]piperidine

    4. 1-(cis-2-methyl-1-(2-thienyl)cyclohexyl)piperidine

    5. 9290nd070r

    6. Gk-11

    7. Nst-001

    8. Unii-9290nd070r

    9. Oto-311

    10. (+)-gacyclidine

    11. Methyl-2-r-(piperidine-1-)-1-(thienyl-2)1-cyclohexene

    12. Gacyclidine [who-dd]

    13. 1-[(1r,2s)-2-methyl-1-(thiophen-2-yl)cyclohexyl]piperidine

    14. Schembl397836

    15. Dtxsid30218313

    16. Piperidine, 1-(2-methyl-1-(2-thienyl)cyclohexyl)-, Cis-

    17. Zinc4213419

    18. Akos016010755

    19. Db13096

    20. Q13560447

    21. Piperidine, 1-((1r,2s)-2-methyl-1-(2-thienyl)cyclohexyl)-, Rel-

    2.4 Create Date
    2005-08-09
    3 Chemical and Physical Properties
    Molecular Weight 263.4 g/mol
    Molecular Formula C16H25NS
    XLogP34.4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count2
    Exact Mass263.17077098 g/mol
    Monoisotopic Mass263.17077098 g/mol
    Topological Polar Surface Area31.5 Ų
    Heavy Atom Count18
    Formal Charge0
    Complexity274
    Isotope Atom Count0
    Defined Atom Stereocenter Count2
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Neuroprotective Agents

    Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids. (See all compounds classified as Neuroprotective Agents.)

    Excitatory Amino Acid Antagonists

    Drugs that bind to but do not activate excitatory amino acid receptors, thereby blocking the actions of agonists. (See all compounds classified as Excitatory Amino Acid Antagonists.)