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    Gamithromycin

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    MARKET PLACE

    PATENTS & EXCLUSIVITIES

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    2D Structure
    Also known as: 145435-72-9, Ml-1709460, Ml-1,709,460, Ml-460, Ze856183s0, (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-11-(((2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one
    Molecular Formula
    C40H76N2O12
    Molecular Weight
    777.0  g/mol
    InChI Key
    VWAMTBXLZPEDQO-UZSBJOJWSA-N
    FDA UNII
    ZE856183S0
    Gamithromycin is an antibiotic used in cattle.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one
    2.1.2 InChI
    InChI=1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1
    2.1.3 InChI Key
    VWAMTBXLZPEDQO-UZSBJOJWSA-N
    2.1.4 Canonical SMILES
    CCCN1CC(C(C(C(OC(=O)C(C(C(C(C(CC1C)(C)O)OC2C(C(CC(O2)C)N(C)C)O)C)OC3CC(C(C(O3)C)O)(C)OC)C)CC)(C)O)O)C
    2.1.5 Isomeric SMILES
    CCCN1C[C@@H]([C@H]([C@]([C@H](OC(=O)[C@@H]([C@H]([C@@H]([C@H]([C@](C[C@H]1C)(C)O)O[C@H]2[C@@H]([C@H](C[C@H](O2)C)N(C)C)O)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)O)(C)OC)C)CC)(C)O)O)C
    2.2 Other Identifiers
    2.2.1 UNII
    ZE856183S0
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Zactran

    2.3.2 Depositor-Supplied Synonyms

    1. 145435-72-9

    2. Ml-1709460

    3. Ml-1,709,460

    4. Ml-460

    5. Ze856183s0

    6. (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-11-(((2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2h-pyran-2-yl)oxy)-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one

    7. (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one

    8. Gamithromycin [usan:inn]

    9. Unii-ze856183s0

    10. (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8

    11. Gamithromycin [mi]

    12. Gamithromycin [inn]

    13. Gamithromycin [usan]

    14. Chembl2107342

    15. Dtxsid90904260

    16. Gamithromycin [green Book]

    17. Ex-a1349

    18. Mfcd09954125

    19. S5328

    20. Zinc169292837

    21. Cs-7858

    22. Db11416

    23. Ds-4441

    24. Gamithromycin 100 Microg/ml In Methanol

    25. Ac-32611

    26. Gamithromycin [ema Epar Veterinary]

    27. Hy-108365

    28. C72760

    29. 435g729

    30. A884620

    31. J-008105

    32. (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-13-((2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylo-hexopyranosyl)oxy)-1-oxa-7-azacyclopentadecan-15-one

    33. (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-13-[(2,6-dideoxy-3-c-methyl-3-o-methyl-alpha-l-ribo-hexopyranosyl)

    34. (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-13-[(2,6-dideoxy-3-cmethyl-3-o-methyl-a-l-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-d-xylo-hexopyranosyl]oxy]-1-oxa-7-azacyclopentadecan-15-one

    35. 1-oxa-7-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-c-methyl-3-o-methyl-.alpha.-l-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-((3,4,6-trideoxy-3-(dimethylamino)-.beta.-d-xylo-hexopyranosyl)oxy)-, (2r,3s,4r,5s,8r,10r,11r,12s,13s,14r)-

    36. 1-oxa-7-azacyclopentadecan-15-one,13-[(2,6-dideoxy-3-c-methyl-3-o-methyl-a-l-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexamethyl-7-propyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-b-d-xylo-hexopyranosyl]oxy]-,[2r-(2r*,3s*,4r*,5s*,8r*,10r*,11r*,12s*,13s*,14r*)]-

    2.4 Create Date
    2012-08-20
    3 Chemical and Physical Properties
    Molecular Weight 777.0 g/mol
    Molecular Formula C40H76N2O12
    XLogP34.9
    Hydrogen Bond Donor Count5
    Hydrogen Bond Acceptor Count14
    Rotatable Bond Count9
    Exact Mass776.53982586 g/mol
    Monoisotopic Mass776.53982586 g/mol
    Topological Polar Surface Area180 Ų
    Heavy Atom Count54
    Formal Charge0
    Complexity1180
    Isotope Atom Count0
    Defined Atom Stereocenter Count18
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    * Cattle:

    Treatment and metaphylaxis of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida and Histophilus somni. The presence of the disease in the herd should be established before metaphylactic use.

    * Pigs:

    Treatment of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis and Bordetella bronchiseptica.

    * Sheep:

    Treatment of infectious pododermatitis (foot rot) associated with virulent Dichelobacter nodosus and Fusobacterium necrophorum requiring systemic treatment.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    5.2 ATC Code

    QJ01FA95