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    Ganciclovir Sodium

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    RELATED EXCIPIENT COMPANIES

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

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    PATENTS & EXCLUSIVITIES

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    $ API Ref.Price (USD/KG) : 467Xls

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    2D Structure
    Also known as: 107910-75-8, Ganciclovir sodium salt, Cytovene iv, Rs-21592 sodium, Ganciclovir (sodium), Ganciclovir sodium [usan]
    Molecular Formula
    C9H12N5NaO4
    Molecular Weight
    277.21  g/mol
    InChI Key
    JJICLMJFIKGAAU-UHFFFAOYSA-M
    An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate
    2.1.2 InChI
    InChI=1S/C9H13N5O4.Na/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17);/q;+1/p-1
    2.1.3 InChI Key
    JJICLMJFIKGAAU-UHFFFAOYSA-M
    2.1.4 Canonical SMILES
    C1=NC2=C(N1COC(CO)CO)N=C(N=C2[O-])N.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Biolf-62

    2. Bw-759

    3. Cytovene

    4. Ganciclovir

    5. Ganciclovir, Monosodium Salt

    6. Gancyclovir

    7. Rs-21592

    2.2.2 Depositor-Supplied Synonyms

    1. 107910-75-8

    2. Ganciclovir Sodium Salt

    3. Cytovene Iv

    4. Rs-21592 Sodium

    5. Ganciclovir (sodium)

    6. Ganciclovir Sodium [usan]

    7. 84245-13-6

    8. Sodium;2-amino-9-(1,3-dihydroxypropan-2-yloxymethyl)purin-6-olate

    9. 107910-75-8 (sodium)

    10. Ganciclovir Sodium (usan)

    11. Natclovir

    12. Cytovene-iv

    13. 9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine, Monosodium Salt

    14. Rs 21592 Sodium

    15. 02l083w284

    16. Unii-02l083w284

    17. Cytovene Iv Sodium

    18. Ganciclovir Sodium (unspecified Mf)

    19. Cytovene Iv (tn)

    20. Ganciclovir (as Sodium)

    21. 6h-purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, Monosodium Salt

    22. Schembl149822

    23. Chembl1200850

    24. Dtxsid20883175

    25. Hy-13637a

    26. Mfcd00873979

    27. Akos015896059

    28. Bs-1004

    29. Ccg-267214

    30. Sodium 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6h-purin-6-one

    31. Db-059667

    32. Cs-0013616

    33. Ft-0656038

    34. D04301

    35. J-002034

    36. Q27231533

    37. Sodium 2-amino-9-((1,3-dihydroxypropan-2-yloxy)methyl)-9h-purin-6-olate

    38. 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6-one Sodium Salt

    39. 6h-purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, Monosodium Salt

    40. 6h-purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-, Sodium Salt

    2.3 Create Date
    2008-02-05
    3 Chemical and Physical Properties
    Molecular Weight 277.21 g/mol
    Molecular Formula C9H12N5NaO4
    Hydrogen Bond Donor Count3
    Hydrogen Bond Acceptor Count8
    Rotatable Bond Count5
    Exact Mass277.07869816 g/mol
    Monoisotopic Mass277.07869816 g/mol
    Topological Polar Surface Area142 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity273
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 3  
    Drug NameGANCICLOVIR SODIUM
    Active IngredientGANCICLOVIR SODIUM
    CompanyPHARMASCIENCE INC (Application Number: A207645)

    2 of 3  
    Drug NameGANCICLOVIR
    Active IngredientGANCICLOVIR SODIUM
    CompanyFRESENIUS KABI USA (Application Number: A090658); LUITPOLD PHARMS INC (Application Number: A202624); MYLAN LABS LTD (Application Number: A204560); PAR STERILE PRODUCTS (Application Number: A204950)

    3 of 3  
    Drug NameCYTOVENE
    Active IngredientGANCICLOVIR SODIUM
    CompanyROCHE PALO (Application Number: N019661)

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antiviral Agents

    Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    DNA Polymerase Inhibitors [MoA]; Nucleoside Analog Antiviral [EPC]; Nucleoside Analog [EXT]; Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor [EPC]