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    GEPIRONE HYDROCHLORIDE

    ACTIVE PHARMA INGREDIENTS

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    2D Structure
    Also known as: Gepirone hcl, Travivo, Gepirone hydrochloride [usan], 83928-66-9, Tgfk07ad, Bmy 13805-1
    Molecular Formula
    C19H30ClN5O2
    Molecular Weight
    395.9  g/mol
    InChI Key
    DGOCVISYYYQFEP-UHFFFAOYSA-N
    FDA UNII
    80C9L8EP6V
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4,4-dimethyl-1-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]piperidine-2,6-dione;hydrochloride
    2.1.2 InChI
    InChI=1S/C19H29N5O2.ClH/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18;/h5-7H,3-4,8-15H2,1-2H3;1H
    2.1.3 InChI Key
    DGOCVISYYYQFEP-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1(CC(=O)N(C(=O)C1)CCCCN2CCN(CC2)C3=NC=CC=N3)C.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    80C9L8EP6V
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 4,4-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-2,6-piperidinedione

    2. Bmy 13805

    3. Bmy-13805

    4. Gepirone

    5. Gepirone Monohydrochloride

    6. Mj 13805

    7. Mj 13805-1

    8. Mj-13805

    2.3.2 Depositor-Supplied Synonyms

    1. Gepirone Hcl

    2. Travivo

    3. Gepirone Hydrochloride [usan]

    4. 83928-66-9

    5. Tgfk07ad

    6. Bmy 13805-1

    7. 80c9l8ep6v

    8. Chembl1204187

    9. Variza

    10. Ariza

    11. Bmy-13805-1

    12. Gepirone Er

    13. 3,3-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)glutarimide Monohydrochloride

    14. Gepirone Hydrochloride (usan)

    15. 2,6-piperidinedione, 4,4-dimethyl-1-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-, Monohydrochloride

    16. Bmy-13805

    17. Unii-80c9l8ep6v

    18. Bmy 138951

    19. Schembl318838

    20. Dtxsid30232812

    21. Org-33062

    22. Gepirone Hydrochloride [mart.]

    23. Gepirone Hydrochloride [who-dd]

    24. Sb19633

    25. Mj-13805

    26. D04314

    27. Q27269140

    28. 2,6-piperidinedione, 4,4-dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, Hydrochloride (1:1)

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 395.9 g/mol
    Molecular Formula C19H30ClN5O2
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count6
    Exact Mass395.2088029 g/mol
    Monoisotopic Mass395.2088029 g/mol
    Topological Polar Surface Area69.6 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity476
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Anti-Anxiety Agents

    Agents that alleviate ANXIETY, tension, and ANXIETY DISORDERS, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. ADRENERGIC BETA-ANTAGONISTS are commonly used in the symptomatic treatment of anxiety but are not included here. (See all compounds classified as Anti-Anxiety Agents.)

    Antidepressive Agents

    Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)

    Serotonin Receptor Agonists

    Endogenous compounds and drugs that bind to and activate SEROTONIN RECEPTORS. Many serotonin receptor agonists are used as ANTIDEPRESSANTS; ANXIOLYTICS; and in the treatment of MIGRAINE DISORDERS. (See all compounds classified as Serotonin Receptor Agonists.)