Please Wait
Applying Filters...
menu
    • menu
    Seqens is an integrated global leader in pharmaceutical solutions & specialty ingredients, & custom-made solutions to our customers.

    Virtual Booth

    Contact Supplier

    Inke S.A: APIs manufacturing plant.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-04-21

    Virtual Booth

    Contact Supplier

    AbbVie CDMO has been working with global companies to develop, manufacture & scale biopharmaceutical products.

    Virtual Booth

    Contact Supplier

    With Fermion, start the journey of your innovative API.

    Virtual Booth

    Contact Supplier

    xyz-pharma-m-2025-04-14

    Virtual Booth

    Contact Supplier

    Menu

    GLPG1205

    DEVELOPMENTS

    DIGITAL CONTENT

    PharmaCompass
    Xls

    Filters

    clear-filterReset all filters
    2D Structure
    Also known as: Glpg1205, Glpg-1205, 1445847-37-9, K9wr6lra5d, 9-(2-cyclopropylethynyl)-2-[[(2s)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one, (s)-2-((1,4-dioxan-2-yl)methoxy)-9-(cyclopropylethynyl)-6,7-dihydro-4h-pyrimido[6,1-a]isoquinolin-4-one
    Molecular Formula
    C22H22N2O4
    Molecular Weight
    378.4  g/mol
    InChI Key
    IRBAWVGZNJIROV-SFHVURJKSA-N
    FDA UNII
    K9WR6LRA5D
    GLPG-1205 is under investigation in clinical trial NCT03725852 (A Clinical Study to Test How Effective and Safe GLPG1205 is for Patients With Idiopathic Pulmonary Fibrosis (IPF)).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    9-(2-cyclopropylethynyl)-2-[[(2S)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one
    2.1.2 InChI
    InChI=1S/C22H22N2O4/c25-22-23-21(28-14-18-13-26-9-10-27-18)12-20-19-6-5-16(4-3-15-1-2-15)11-17(19)7-8-24(20)22/h5-6,11-12,15,18H,1-2,7-10,13-14H2/t18-/m0/s1
    2.1.3 InChI Key
    IRBAWVGZNJIROV-SFHVURJKSA-N
    2.1.4 Canonical SMILES
    C1CC1C#CC2=CC3=C(C=C2)C4=CC(=NC(=O)N4CC3)OCC5COCCO5
    2.1.5 Isomeric SMILES
    C1CC1C#CC2=CC3=C(C=C2)C4=CC(=NC(=O)N4CC3)OC[C@@H]5COCCO5
    2.2 Other Identifiers
    2.2.1 UNII
    K9WR6LRA5D
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 9-cyclopropylethynyl-2-((s)-1-(1,4)dioxan-2-ylmethoxy)-6,7-dihydropyrimido(6,1-a)isoquinolin-4-one

    2. Glpg1205

    2.3.2 Depositor-Supplied Synonyms

    1. Glpg1205

    2. Glpg-1205

    3. 1445847-37-9

    4. K9wr6lra5d

    5. 9-(2-cyclopropylethynyl)-2-[[(2s)-1,4-dioxan-2-yl]methoxy]-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one

    6. (s)-2-((1,4-dioxan-2-yl)methoxy)-9-(cyclopropylethynyl)-6,7-dihydro-4h-pyrimido[6,1-a]isoquinolin-4-one

    7. Unii-k9wr6lra5d

    8. Chembl3716365

    9. Schembl15051377

    10. Gtpl10171

    11. Bdbm50548385

    12. At30151

    13. Db15346

    14. Compound 122 [wo2013092791a1]

    15. Hy-135303

    16. Cs-0110898

    2.4 Create Date
    2013-07-29
    3 Chemical and Physical Properties
    Molecular Weight 378.4 g/mol
    Molecular Formula C22H22N2O4
    XLogP32.4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass378.15795719 g/mol
    Monoisotopic Mass378.15795719 g/mol
    Topological Polar Surface Area60.4 Ų
    Heavy Atom Count28
    Formal Charge0
    Complexity757
    Isotope Atom Count0
    Defined Atom Stereocenter Count1
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1