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    Guanethidine

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    REF. STANDARDS & IMPURITIES

    PharmaCompass
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    2D Structure
    Also known as: 645-43-2, Guanethidine monosulfate, Ismelin, Ismelin sulfate, Guanethidine (sulfate), Guanethidine sulphae
    Molecular Formula
    C10H24N4O4S
    Molecular Weight
    296.39  g/mol
    InChI Key
    YUFWAVFNITUSHI-UHFFFAOYSA-N
    FDA UNII
    5UBY8Y002G
    An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric acid
    2.1.2 InChI
    InChI=1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)
    2.1.3 InChI Key
    YUFWAVFNITUSHI-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C1CCCN(CCC1)CCN=C(N)N.OS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    5UBY8Y002G
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. ((2-hexahydro-1(2h)-azocinyl)ethyl)guanidine

    2. Guanethidine

    3. Guanethidine Monosulfate

    4. Guanethidine Sulfate (1:1)

    5. Guanethidine Sulfate (1:2)

    6. Guanethidine Sulfate (2:1)

    7. Guanethidine Sulfate (2:1), 14c-labeled

    8. Ismelin

    9. Isobarin

    10. Monosulfate, Guanethidine

    11. Octadine

    12. Oktadin

    13. Sulfate, Guanethidine

    2.3.2 Depositor-Supplied Synonyms

    1. 645-43-2

    2. Guanethidine Monosulfate

    3. Ismelin

    4. Ismelin Sulfate

    5. Guanethidine (sulfate)

    6. Guanethidine Sulphae

    7. 1-(2-(azocan-1-yl)ethyl)guanidine Sulfate

    8. Guanethidine Monosulphate

    9. 645-43-2 (sulfate)

    10. 5uby8y002g

    11. 2-[2-(azocan-1-yl)ethyl]guanidine;sulfuric Acid

    12. Guanidine, (2-(hexahydro-1(2h)-azocinyl)ethyl)-, Sulfate (1:1)

    13. Guanidine, [2-(hexahydro-1(2h)-azocinyl)ethyl]-, Sulfate (1:1)

    14. Isobarin

    15. Octadin

    16. Octadine

    17. Iporal

    18. Guanetidin Sulfate

    19. Guanethidinesulfate

    20. 2-(octahydro-1-azocinyl)ethyl Guanidine Sulphate

    21. Guanethidine Bisulfate

    22. (2-(hexahydro-1(2h)-azocinyl)ethyl) Guanidine Hydrogen Sulfate

    23. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulfate (1:1)

    24. Ismelin Sulfate (2:1)

    25. Su 5864 Sulfate (1:1)

    26. Chebi:51016

    27. Nsc29863

    28. Guanethidine Monosulfate [usan]

    29. Einecs 211-442-0

    30. Unii-5uby8y002g

    31. Isomelin

    32. Guanethidine Sulfate (1:1)

    33. N-(2-guanidino Ethyl)heptamethylenimine Sulfate

    34. Prestwick_249

    35. Ismelin (tn)

    36. [2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate (2:1)

    37. Guanethidine Monosulfate [usan:usp]

    38. Azocine, Sulfate (2:1)

    39. Chembl1345

    40. Schembl51039

    41. Guanethidine Monosulphate Usp

    42. Guanethidine Sulfate (jp17)

    43. Spectrum1500323

    44. Guanethidine Monosulfate (usp)

    45. Schembl11658850

    46. Hms501k21

    47. (2-(hexahydro-(2h)-azocin-1-yl)ethyl)guanidinium Sulphate

    48. Dtxsid20110019

    49. Hms1568p16

    50. Hms1920b19

    51. Hms2091j05

    52. Hms3749o19

    53. Pharmakon1600-01500323

    54. Methyltriallylammoniumbromide

    55. Hy-b0800

    56. Ac-479

    57. Ccg-39688

    58. Guanethidine Monosulfate [mi]

    59. Mfcd00035403

    60. Nsc757045

    61. S5496

    62. Akos015856688

    63. Akos026750543

    64. Wln: T8ntj A2myzum & 2wsqq

    65. Cs-3931

    66. Nsc-757045

    67. Guanethidine Monosulfate [mart.]

    68. Guanethidine Monosulfate [vandf]

    69. Guanethidine Monosulfate [usp-rs]

    70. Guanethidine Monosulfate [who-dd]

    71. Ncgc00094691-01

    72. Ncgc00094691-02

    73. As-57397

    74. .beta.-1-azacyclooctylethylguanidine Sulfate

    75. Ft-0603504

    76. Guanethidine Monosulfate [ep Impurity]

    77. D04382

    78. Esimil Component Guanethidine Monosulfate

    79. Guanethidine Monosulfate [ep Monograph]

    80. Guanethidine Monosulfate [usp Monograph]

    81. [2-(octahydro-1-azocinyl)ethyl]guanidine Sulfate

    82. Guanethidine Monosulfate Component Of Esimil

    83. N-[2-(azocan-1-yl)ethyl]guanidine; Sulfuric Acid

    84. Sr-05000001637

    85. 1-[2-(azocan-1-yl)ethyl]guanidine (1/2h2so4)

    86. Sr-05000001637-1

    87. [2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate

    88. N''-[2-(azocan-1-yl)ethyl]guanidine; Sulfuric Acid

    89. Q27122277

    90. N-[2-(hexahydro-1(2h)-azocinyl)ethyl]guanidine Sulfate

    91. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulfate (1:1).

    92. (2-(hexahydro-1(2h)-azocinyl)ethyl)guanidine Sulphate (1:1).

    93. Guanidine, (2-(hexahydro-1(2h)-azocinyl)ethyl)-, Sulphate (1:1)

    94. Guanethidine Monosulfate, United States Pharmacopeia (usp) Reference Standard

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 296.39 g/mol
    Molecular Formula C10H24N4O4S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count6
    Rotatable Bond Count3
    Exact Mass296.15182643 g/mol
    Monoisotopic Mass296.15182643 g/mol
    Topological Polar Surface Area151 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity248
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antihypertensive Agents

    Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

    Sympatholytics

    Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)

    Adrenergic Agents

    Drugs that act on adrenergic receptors or affect the life cycle of adrenergic transmitters. Included here are adrenergic agonists and antagonists and agents that affect the synthesis, storage, uptake, metabolism, or release of adrenergic transmitters. (See all compounds classified as Adrenergic Agents.)