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    Halofantrine Hydrochloride

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    REF. STANDARDS & IMPURITIES

    PharmaCompass
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    2D Structure
    Also known as: 36167-63-2, Halfan, Halofantrine hcl, Halofantrine hydrochloride [usan], Wr-171669, Skf-102886
    Molecular Formula
    C26H31Cl3F3NO
    Molecular Weight
    536.9  g/mol
    InChI Key
    WANGFTDWOFGECH-UHFFFAOYSA-N
    FDA UNII
    H77DL0Y630
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol;hydrochloride
    2.1.2 InChI
    InChI=1S/C26H30Cl2F3NO.ClH/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23;/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3;1H
    2.1.3 InChI Key
    WANGFTDWOFGECH-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl
    2.2 Other Identifiers
    2.2.1 UNII
    H77DL0Y630
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol Hcl

    2. Halfan

    3. Halofantrine

    4. Wr 171,699

    5. Wr 171669

    6. Wr-171,669

    7. Wr-171699

    2.3.2 Depositor-Supplied Synonyms

    1. 36167-63-2

    2. Halfan

    3. Halofantrine Hcl

    4. Halofantrine Hydrochloride [usan]

    5. Wr-171669

    6. Skf-102886

    7. Halofantrine (hydrochloride)

    8. 3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol;hydrochloride

    9. (-)-halofantrine Hydrochloride

    10. 2b7enl644k

    11. 106927-11-1

    12. Halofantrine Hydrochloride, (-)-

    13. H77dl0y630

    14. 3-(dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol Hydrochloride

    15. 9-(3-(dibutylamino)-1-hydroxypropyl)-1,3-dichloro-6-(trifluoromethyl)phenanthrene Hydrochloride

    16. Dl-wr 171669

    17. Ncgc00016833-01

    18. Skf-102886;wr-171669

    19. Dsstox_cid_25464

    20. Dsstox_rid_80895

    21. Dsstox_gsid_45464

    22. Halofantrine Hydrochloride (usan)

    23. Halofantrino

    24. Halofantrino [spanish]

    25. Mls002154111

    26. 66051-64-7

    27. Cas-36167-63-2

    28. (+-)-halofantrine Hydrochloride

    29. Wr 171669

    30. Wr-171,669

    31. Smr001233418

    32. Einecs 252-895-4

    33. Unii-h77dl0y630

    34. Halfan (tn)

    35. Mfcd00879136

    36. Skf 102886

    37. Halofantrine Hydrochlorid

    38. 1,3-dichloro-6-trifluoromethyl-9-(3-(dibutylamino)-1-hydroxypropyl)phenanthrene Hcl

    39. 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-(di-n-butylamino)propanol Hydrochloride

    40. Unii-2b7enl644k

    41. 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-9-phenanthrenemethanol Hydrochloride

    42. Schembl466895

    43. Chembl1200901

    44. Dtxsid0045464

    45. Hy-a0148a

    46. Hms1571o03

    47. Tox21_110637

    48. Akos030254762

    49. Tox21_110637_1

    50. Ccg-221031

    51. Halofantrine Hydrochloride [mi]

    52. Sk&f-102866

    53. Ncgc00179250-03

    54. (+/-)-halofantrine Hydrochloride

    55. 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)phenanthren-1-methanol Hydrochloride

    56. 9-phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, Hydrochloride

    57. Halofantrine Hydrochloride [mart.]

    58. Halofantrine Hydrochloride [vandf]

    59. Halofantrine Hydrochloride [who-dd]

    60. Cs-0031225

    61. Ft-0600399

    62. D02485

    63. Halofantrine Hydrochloride [ep Impurity]

    64. Halofantrine Hydrochloride [orange Book]

    65. Halofantrine Hydrochloride [ep Monograph]

    66. 167h632

    67. Halofantrine Hydrochloride, >=98% (hplc), Solid

    68. Sr-01000841216

    69. Sr-01000841216-2

    70. W-106636

    71. Halofantrine Hydrochloride, European Pharmacopoeia (ep) Reference Standard

    72. 1-[1,3-dichloro-6-trifluoromethyl-9-phenanthryl]-3-di(n-butyl)aminopropanol Hydrochloride

    73. 1,3-dichloro-.alpha.-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-9-phenanthrenemethanol Hydrochloride

    74. 1,3-dichloro-alpha-[2-(dibutylamino)ethyl]-6-(trifluoromethyl)-9-phenanthrenemethanol;(+/-)-halofantrine Hydrochloride

    75. 9-phenanthrenemethanol, 1,3-dichloro-.alpha.-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, Hydrochloride

    76. 9-phenanthrenemethanol, 1,3-dichloro-.alpha.-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, Hydrochloride (1:1)

    77. 9-phenanthrenemethanol, 1,3-dichloro-.alpha.-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, Hydrochloride, (-)-

    78. 9-phenanthrenemethanol, 1,3-dichloro-alpha-(2-(dibutylamino)ethyl)-6-(trifluoromethyl)-, Hydrochloride, (-)-

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 536.9 g/mol
    Molecular Formula C26H31Cl3F3NO
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count10
    Exact Mass535.142332 g/mol
    Monoisotopic Mass535.142332 g/mol
    Topological Polar Surface Area23.5 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity584
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Antimalarials

    Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585) (See all compounds classified as Antimalarials.)