1. Helium 4
2. Helium-4
1. 7440-59-7
2. He
3. Atomic Helium
4. Helium-4
5. P-helium
6. O-helium
7. Helio
8. [he]
9. Helium(0)
10. Helium (usp)
11. Helium [usp]
12. E939
13. Ins No.939
14. E-939
15. Chebi:30217
16. Ins-939
17. 206gf3gb41
18. Hsdb 553
19. Einecs 231-168-5
20. Un1046
21. Un1963
22. Helium Atom
23. Unii-206gf3gb41
24. Helium, Compressed
25. Einecs 275-187-7
26. Helium [vandf]
27. Helium [hsdb]
28. Helium [fcc]
29. Helium [who-dd]
30. Helium [mi]
31. Helium [mart.]
32. Helium [green Book]
33. Helium, Compressed [un1046] [nonflammable Gas]
34. Helium [ep Monograph]
35. Helium [usp Monograph]
36. Helium, >=99.995%
37. Helium, >=99.999%
38. Chembl1796997
39. Dtxsid7036402
40. Chebi:33681
41. Db09155
42. 71086-78-7
43. Helium, Messer(r) Cangas, 99.999%
44. Q560
45. E 939
46. D04420
47. Helium, Refrigerated Liquid (cryogenic Liquid)
48. Helium, Compressed [un1046] [nonflammable Gas]
49. Helium, Refrigerated Liquid (cryogenic Liquid) [un1963] [nonflammable Gas]
| Molecular Weight | 4.00260 g/mol |
|---|---|
| Molecular Formula | He |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 0 |
| Rotatable Bond Count | 0 |
| Exact Mass | 4.002603254 g/mol |
| Monoisotopic Mass | 4.002603254 g/mol |
| Topological Polar Surface Area | 0 Ų |
| Heavy Atom Count | 1 |
| Formal Charge | 0 |
| Complexity | 0 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Because of its lower lipid solubility, helium is used by divers to replace nitrogen to prevent nitrogen ... /CNS depression/ at depth. Even at diving gas mixture of 50% helium, divers suffer no adverse effects as long as a normal partial pressure of oxygen is maintained the mixture at depth.
Goldfrank, L.R., Goldfrank's Toxicologic Emergencies 9th Ed. 2011., McGraw-Hill, New York, N.Y., p. 1644
The primary uses of helium are in pulmonary function testing, the treatment of respiratory obstruction, laser airway surgery, as a label in imaging studies, and for diving at depth.
Brunton, L. Chabner, B, Knollman, B. Goodman and Gillman's The Pharmaceutical Basis of Therapeutics, Twelth Edition, McGraw Hill Medical, New York, NY. 2011, p. 560
/FORMER USE/ as diluent in anesthetic mixt containing cyclopropane and oxygen, helium decr infammability. However, it is not widely used for this purpose. It has...been employed during open-heart surgery; helium-oxygen mixt are insufflated into lung during cardiopulmonary bypass when ventilation of lung has been discontinued. Helium has antiarrhythmic effect in exptl coronary occlusion which is as yet unexplained...
Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 898
Divers breathing compressed air are restricted to 45 m depth because of the ... /CNS depressant/ effects of nitrogen and toxic action of oxygen at increased pressures. Substitution of oxygen-helium for compressed air has permitted divers to reach 600 m. However, at depths greater than 160 m, signs and symptoms of the high pressure nervous syndrome (HPNS) occur. The objective is to ameliorate the symptoms of pressure-induced high pressure nervous syndrome by the addition of small amt of CNS depressant nitrogen to the oxygen-helium mixt to form the Trimix breathing gas. The results permit the conclusion that divers may be compressed safely to depths as great as 686 m. The technique requires a slow exponential compression over days, with frequent stages lasting 14 hr or more, the use of 5-8% (by vol) nitrogen in Heliox and careful selection of the divers.
Bennett PB, McLeod M; Philos Tran R Soc Lond (Biol) 304 (1118): 105-17 (1984)
HIGH PRESSURE GAS. CAN CAUSE RAPID SUFFOCATION. Store and use with adequate ventilation. Use equipment rated for cylinder pressure. Cylinder temperature should not exceed 52C (125F). Close valve after each use and when empty. Use in accordance with the Material Safety Data Sheet.
Aero All Gas Company; HELIUM gas; Available from, as of March 6, 2014: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2e9012ae-8ff1-4858-a1e9-e2c3959b2f57
Administration of Helium may be hazardous or contraindicated. For use only by or under the supervision of a licensed practitioner who is experienced in the use administration of Helium and is familiar with the indications, effects, dosages, methods, and frequency and duration of administration, and with the hazards, contraindications and side effects and the precautions to be taken.
Aero All Gas Company; HELIUM gas; Available from, as of March 6, 2014: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2e9012ae-8ff1-4858-a1e9-e2c3959b2f57
For use in patients who are not getting enough oxygen into their blood due to blockages in the lungs from pathological conditions or injuries. Suggested potential benefit in upper airway obstruction, in severe asthma, and in exacerbations of COPD/COLD. Helium may be used in place of carbon monoxide during laparoscopic surgeries as it lowers the risk of developing respiratory acidosis in selected patients.
Helium provides lung ventilation and prevents narrowing or collapse in respiratory units. It increases the tendency to laminar flow and reduces the resistance in turbulent flow, leading to more efficient penetration of gases to the distal alveoli, higher minute volumes and improved ventilation.
V - Various
V03 - All other therapeutic products
V03A - All other therapeutic products
V03AN - Medical gases
V03AN03 - Helium
Route of Elimination
Respiration
Helium ... is quite insolubility in body tissues.
Brunton, L. Chabner, B, Knollman, B. Goodman and Gillman's The Pharmaceutical Basis of Therapeutics, Twelth Edition, McGraw Hill Medical, New York, NY. 2011, p. 560
0.8 seconds
Due to its lower density, helium achieves more effective flow of gas due to lowered resistance to gas flow within the airways and reduces the work of breathing by decreasing the pressure gradient needed to achieve a turbulent flow. Helium has a higher diffusion coefficient for carbon dioxide relative to oxygen thus promotes exhalation of trapped carbon dioxide. This reduces hypercapnia and normalizes pH. Helium increases the coronary collateral circulation and enhances the vasodilatory effects of inhaled nitric oxide on pulmonary vessels. It is suggested to possess neuroprotective properties. Cardioprotective effects against ischemia are mediated through early and late preconditioning by exposing the myocardial tissues to short ischemic episodes. Studies show that helium is associated with activation of pro-survival signalling kinases and inhibition of the opening of mitochondrial permeability transition pore (mPTP).
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