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    Hetastarch

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Hetastarch, 9004-62-0, 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol, 2-hydroxyethyl cellulose, Hydroxyethyl-cellulose, Schembl23306563
    Molecular Formula
    C29H52O21
    Molecular Weight
    736.7  g/mol
    InChI Key
    CWSZBVAUYPTXTG-UHFFFAOYSA-N
    Hetastarch is a synthetic, nonionic hydroxyethyl derivative of starch used as a plasma expander when prepared in an isotonic solution. Upon intravenous administration, hydroxyethyl starch colloid increases blood volume and thus improves circulation. This agent is almost exclusively excreted by the kidneys and is potentially nephrotoxic.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol
    2.1.2 InChI
    InChI=1S/C29H52O21/c1-10-15(34)16(35)24(13(8-33)45-10)49-28-20(39)18(37)25(50-29-26(43-5-4-30)21(40)23(42-3)12(7-32)47-29)14(48-28)9-44-27-19(38)17(36)22(41-2)11(6-31)46-27/h10-40H,4-9H2,1-3H3
    2.1.3 InChI Key
    CWSZBVAUYPTXTG-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)OC)O)O)OC4C(C(C(C(O4)CO)OC)O)OCCO)O)O)O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Aldiamed

    2. Hydroxyethylcellulose

    3. Hydroxyethylcellulose, Sodium Salt

    4. Hydroxyl Ethyl Cellulose

    5. Lacrigel

    6. Minims Artificial Tears

    7. Natrosol 250

    2.2.2 Depositor-Supplied Synonyms

    1. Hetastarch

    2. 9004-62-0

    3. 5-[6-[[3,4-dihydroxy-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxymethyl]-3,4-dihydroxy-5-[4-hydroxy-3-(2-hydroxyethoxy)-6-(hydroxymethyl)-5-methoxyoxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)-2-methyloxane-3,4-diol

    4. 2-hydroxyethyl Cellulose

    5. Hydroxyethyl-cellulose

    6. Schembl23306563

    7. Dtxsid60873934

    8. Ft-0627136

    9. H11622

    10. 2-hydroxyethyl Cellulose; Cellulose Hydroxyethyl Ether

    11. 2-o-(2-hydroxyethyl)-4-o-methylhexopyranosyl-(1->4)-[4-o-methylhexopyranosyl-(1->6)]hexopyranosyl-(1->5)-2,6-anhydro-1-deoxyheptitol

    2.3 Create Date
    2008-07-11
    3 Chemical and Physical Properties
    Molecular Weight 736.7 g/mol
    Molecular Formula C29H52O21
    XLogP3-7.7
    Hydrogen Bond Donor Count11
    Hydrogen Bond Acceptor Count21
    Rotatable Bond Count15
    Exact Mass736.30010866 g/mol
    Monoisotopic Mass736.30010866 g/mol
    Topological Polar Surface Area315 Ų
    Heavy Atom Count50
    Formal Charge0
    Complexity999
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count20
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 FDA Pharmacological Classification
    4.1.1 Pharmacological Classes
    Osmotic Activity [MoA]; Plasma Volume Expander [EPC]; Starch [CS]; Increased Intravascular Volume [PE]