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    Hexaethylene Glycol

    ACTIVE PHARMA INGREDIENTS

    DIGITAL CONTENT

    PharmaCompass
    $ API Ref.Price (USD/KG) : 953Xls

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    2D Structure
    Also known as: 2615-15-8, 3,6,9,12,15-pentaoxaheptadecane-1,17-diol, Hexagol, Hexaoxyethylene glycol, Ho-peg6-oh, Peg-6
    Molecular Formula
    C12H26O7
    Molecular Weight
    282.33  g/mol
    InChI Key
    IIRDTKBZINWQAW-UHFFFAOYSA-N
    Polyethylene glycol 300 (PEG 300) is a water-miscible polyether with an average molecular weight of 300 g/mol. It is a clear viscous liquid at room temperature with non-volatile, stable properties. Polyethylene glycols are widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. They serve as solubilizers, excipients, lubricants, and chemical reagents. Low molecular weight glycols are observed to exhibit antibacterial properties as well. PEG 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol
    2.1.2 InChI
    InChI=1S/C12H26O7/c13-1-3-15-5-7-17-9-11-19-12-10-18-8-6-16-4-2-14/h13-14H,1-12H2
    2.1.3 InChI Key
    IIRDTKBZINWQAW-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    C(COCCOCCOCCOCCOCCO)O
    2.2 Synonyms
    2.2.1 Depositor-Supplied Synonyms

    1. 2615-15-8

    2. 3,6,9,12,15-pentaoxaheptadecane-1,17-diol

    3. Hexagol

    4. Hexaoxyethylene Glycol

    5. Ho-peg6-oh

    6. Peg-6

    7. Polyethylene Glycol 300

    8. 2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanol

    9. Polyoxyethylene (6)

    10. Hexaethyleneglycol

    11. Nsc 201209

    12. Ethanol, 2,2'-(oxybis(ethyleneoxyethyleneoxy))di-

    13. Chebi:49793

    14. Mfcd00002877

    15. Einecs 220-045-1

    16. P6g

    17. Oh-peg6-oh

    18. Brn 1638281

    19. Ai3-01457

    20. Hexa[ethylene Glycol]

    21. Hexaethylene Glycol, 97%

    22. 2,2'-[oxybis(ethyleneoxyethyleneoxy)]bisethanol

    23. Schembl38159

    24. 4-01-00-02406 (beilstein Handbook Reference)

    25. Chembl1235082

    26. Dtxsid2058629

    27. Wln: Q2/o2/ 5q

    28. Amy19025

    29. Zinc4521548

    30. Nsc201209

    31. Akos015839803

    32. Nsc-201209

    33. Ncgc00159371-02

    34. Ncgc00159371-03

    35. As-19157

    36. Bp-21034

    37. Bp-21475

    38. Sy024148

    39. Trans-2-o-tolylcyclopropanecarboxylic Acid

    40. Hy-141230

    41. 3,9,12,15-pentaoxaheptadecane-1,17-diol

    42. Cs-0115001

    43. Ft-0602028

    44. H1432

    45. Hexaethylene Glycol, Purum, >=95.0% (gc)

    46. Ethanol,2'-[oxybis(ethyleneoxyethyleneoxy)]di-

    47. A877353

    48. J-016283

    49. Q27104720

    50. Ethanol,2'-[oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy)]bis-

    51. Ethanol, 2,2'-(oxybis(oxy-2,1-ethanediyloxy-2,1-ethanediyloxy))bis-

    52. 2-[2-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethanol

    53. 6529-43-7

    2.3 Create Date
    2005-03-26
    3 Chemical and Physical Properties
    Molecular Weight 282.33 g/mol
    Molecular Formula C12H26O7
    XLogP3-1.9
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count7
    Rotatable Bond Count16
    Exact Mass282.16785316 g/mol
    Monoisotopic Mass282.16785316 g/mol
    Topological Polar Surface Area86.6 Ų
    Heavy Atom Count19
    Formal Charge0
    Complexity141
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Indicated as a lubricant in over-the-counter ophthalmic solutions to temporarily relieve redness, burning and irritation of the eyes.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    PEGs act as nonionic surfactant to decrease surface tension and condition the stratum corneum, thus enhance the diffusion of other molecules or drugs through the skin.

    5.2 Absorption, Distribution and Excretion

    Absorption

    PEGs can be absorbed by the gastrointestinal tract following oral administration with the fraction absorbed being dependent on the molecular weight of the compound. It is likely to display minimal absorption through the intact skin, but may penetrate through injured skin with compromised barrier function.

    Route of Elimination

    After oral and intravenous exposure, PEGs are excreted mainly unchanged in the urine and faeces.

    Volume of Distribution

    No pharmacokinetic data available.

    Clearance

    No pharmacokinetic data available.

    5.3 Metabolism/Metabolites

    Proportion of absorbed PEGs may be metabolized to lower oligomers, glycolic acid, hydroxyglycolic acids and the diglycolic acids homologs, carbon dioxide that is exhaled, and to a minor extent, oxalic acid.

    5.4 Biological Half-Life

    No pharmacokinetic data available.

    5.5 Mechanism of Action

    Due to their physical properties, PEG acts as a surfactant by coating the eye. It provides lubrication and surface protection in dry eyes.