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    Hydroconchinine

    PharmaCompass
    Xls

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    2D Structure
    Also known as: Hydroquinidine, 1435-55-8, Hydroconquinine, Hydroconchinine, Dihydroquinine, (+)-hydroquinidine
    Molecular Formula
    C20H26N2O2
    Molecular Weight
    326.4  g/mol
    InChI Key
    LJOQGZACKSYWCH-LHHVKLHASA-N
    FDA UNII
    8P68XPY4HG
    Hydroquinidine is under investigation in clinical trial NCT00927732 (Hydroquinidine Versus Placebo in Patients With Brugada Syndrome).
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (S)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
    2.1.2 InChI
    InChI=1S/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14-,19+,20-/m0/s1
    2.1.3 InChI Key
    LJOQGZACKSYWCH-LHHVKLHASA-N
    2.1.4 Canonical SMILES
    CCC1CN2CCC1CC2C(C3=C4C=C(C=CC4=NC=C3)OC)O
    2.1.5 Isomeric SMILES
    CC[C@H]1CN2CC[C@H]1C[C@@H]2[C@H](C3=C4C=C(C=CC4=NC=C3)OC)O
    2.2 Other Identifiers
    2.2.1 UNII
    8P68XPY4HG
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Dihydroquinine

    2. Hydroquinidine

    3. Hydroquinidine Dihydrochloride, (1beta,4beta,3s)-(+-)-isomer

    4. Hydroquinidine Dihydrochloride, (3alpha,9s)-(+-)-isomer

    5. Hydroquinidine Hydrochloride

    6. Hydroquinidine Monosulfate

    7. Hydroquinidine Monosulfate, (1beta,3alpha,4beta,8alpha,9r)-isomer

    8. Hydroquinidine Monosulfate, (1beta,3alpha,4beta,9s)-isomer

    9. Hydroquinidine Sulfate

    10. Hydroquinidine Sulfate, (9s)-isomer

    11. Hydroquinidine, (+-)-isomer

    12. Hydroquinidine, (1beta, 3alpha,4beta,8alpha,9r)-isomer

    13. Hydroquinidine, (1beta,3alpha,4beta,9s)-isomer

    14. Hydroquinidine, (1beta,4beta,9s)-(+-)-isomer

    15. Hydroquinidine, (3alpha,9s)-(+-)-isomer

    16. Hydroquinidine, (8alpha,9r)-isomer

    17. Hydroquinidine, (8alpha,9s)-isomer

    18. Hydroquinidine, (9r)-isomer

    19. Hydroquinidine, (9s)-(+-)-isomer

    20. Hydroquinine

    21. Lcn 834

    22. Lcn-834

    23. Lentoquine

    24. Srcor

    2.3.2 Depositor-Supplied Synonyms

    1. Hydroquinidine

    2. 1435-55-8

    3. Hydroconquinine

    4. Hydroconchinine

    5. Dihydroquinine

    6. (+)-hydroquinidine

    7. (9s)-10,11-dihydro-6'-methoxycinchonan-9-ol

    8. 8p68xpy4hg

    9. Dihydrochinidin

    10. 10,11-dihydroquinidine

    11. Mfcd00135599

    12. Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9s)-

    13. (s)-((1s,2r,4s,5r)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol

    14. (+)-dihydroquinidine

    15. Einecs 215-862-5

    16. Gnf-pf-2067

    17. Unii-8p68xpy4hg

    18. Hydroquinidine, 95%

    19. Hydroquinidine [mi]

    20. Schembl308961

    21. (8r,9s)-10,11-dihydro-6'-methoxy-9-cinchonanol

    22. Chembl531472

    23. Megxp0_001892

    24. Hydroquinidine [who-dd]

    25. Acon1_001481

    26. Dtxsid50862110

    27. Act08913

    28. Zinc3977899

    29. S4648

    30. S4658

    31. Ccg-267773

    32. Ccg-267774

    33. Db15300

    34. Nsc 757410

    35. Ncgc00180461-01

    36. Ncgc00180461-02

    37. Ncgc00385753-01

    38. (+)-dihydroquinidine, Analytical Standard

    39. As-16052

    40. A20646

    41. Fmoc-(s)-3-amino-4-(2-naphthyl)butanoicacid

    42. 435h558

    43. Q5276449

    44. Brd-k98182306-001-01-3

    45. (9s)-10,11-dihydro-6'-methoxycinchonan-9-ol;hydroquinidine

    46. (s)-((2r,4s,5r)-5-ethylquinuclidin-2-yl)(6-methoxyquinolin-4-yl)methanol

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 326.4 g/mol
    Molecular Formula C20H26N2O2
    XLogP33.1
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass326.199428076 g/mol
    Monoisotopic Mass326.199428076 g/mol
    Topological Polar Surface Area45.6 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity432
    Isotope Atom Count0
    Defined Atom Stereocenter Count4
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Parasympatholytics

    Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS. (See all compounds classified as Parasympatholytics.)

    Anti-Arrhythmia Agents

    Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade. (See all compounds classified as Anti-Arrhythmia Agents.)

    4.2 ATC Code

    C - Cardiovascular system

    C01 - Cardiac therapy

    C01B - Antiarrhythmics, class i and iii

    C01BA - Antiarrhythmics, class ia

    C01BA13 - Hydroquinidine