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    Hydroxyethyl Cellulose

    ACTIVE PHARMA INGREDIENTS

    DIGITAL CONTENT

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 9Xls

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    2D Structure
    Also known as: Hydroxyethylcellulose, Cellulose hydroxyethyl ether, 2-hydroxyethyl cellulose ether, Db11602
    Molecular Formula
    C36H70O19
    Molecular Weight
    806.9  g/mol
    InChI Key
    DFJVHKAPIXJTSC-UHFFFAOYSA-N
    Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-[[3,4,5-tris(2-hydroxypropoxy)-6-[4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol
    2.1.2 InChI
    InChI=1S/C36H70O19/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41/h19-44H,9-18H2,1-8H3
    2.1.3 InChI Key
    DFJVHKAPIXJTSC-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC(COCC1C(C(C(C(O1)OC2C(OC(C(C2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Aldiamed

    2. Hydroxyethylcellulose

    3. Hydroxyethylcellulose, Sodium Salt

    4. Hydroxyl Ethyl Cellulose

    5. Lacrigel

    6. Minims Artificial Tears

    7. Natrosol 250

    2.2.2 Depositor-Supplied Synonyms

    1. Hydroxyethylcellulose

    2. Cellulose Hydroxyethyl Ether

    3. 2-hydroxyethyl Cellulose Ether

    4. Db11602

    2.3 Create Date
    2005-09-14
    3 Chemical and Physical Properties
    Molecular Weight 806.9 g/mol
    Molecular Formula C36H70O19
    XLogP3-3
    Hydrogen Bond Donor Count8
    Hydrogen Bond Acceptor Count19
    Rotatable Bond Count28
    Exact Mass806.45113000 g/mol
    Monoisotopic Mass806.45113000 g/mol
    Topological Polar Surface Area263 Ų
    Heavy Atom Count55
    Formal Charge0
    Complexity986
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count18
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    For alleviating surface irritation in topical ocular administrations, such as artificial tear solutions. Hydroxyethyl cellulose is also found in topical formulations to aid in more efficient drug diffusion across the membranes.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Hydroxyethyl cellulose acts as a demulcent by relieving inflammation or irritation and dryness of eyes. It acts as one of the key ingredient and viscosity-enhancing agent to prolong corneal contact time and increase intraocular drug levels.

    5.2 Mechanism of Action

    Interacts with the solid surface through hydrogen bonding to thicken and prolong the formation time of a water-retaining film. Hydroxyethyl cellulose acts as a drug carrier or microsphere to entrap other drug molecules and form a viscous gel-like dispersion, enabling drug diffusion across biological membranes.