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    Idebenone

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    2D Structure
    Also known as: 58186-27-9, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, Idebenona, Idebenonum, Sovrima, Hydroxydecyl ubiquinone
    Molecular Formula
    C19H30O5
    Molecular Weight
    338.4  g/mol
    InChI Key
    JGPMMRGNQUBGND-UHFFFAOYSA-N
    FDA UNII
    HB6PN45W4J
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
    2.1.2 InChI
    InChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
    2.1.3 InChI Key
    JGPMMRGNQUBGND-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=C(C(=O)C(=C(C1=O)OC)OC)CCCCCCCCCCO
    2.2 Other Identifiers
    2.2.1 UNII
    HB6PN45W4J
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Cv 2619

    2. Cv-2619

    3. Hydroxydecyl Ubiquinone

    4. Noben

    5. Raxone

    2.3.2 Depositor-Supplied Synonyms

    1. 58186-27-9

    2. 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione

    3. Idebenona

    4. Idebenonum

    5. Sovrima

    6. Hydroxydecyl Ubiquinone

    7. Cv 2619

    8. Cv-2619

    9. Oristar Hdu

    10. Brn 2001459

    11. Chebi:31687

    12. 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone

    13. 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinone

    14. Nsc-759228

    15. Hb6pn45w4j

    16. 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione

    17. 2,5-cyclohexadiene-1,4-dione, 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-

    18. 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinone

    19. Raxone

    20. 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-1,4-benzoquinone

    21. Mfcd00274552

    22. Ncgc00160514-01

    23. 2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylbenzo-1,4-quinone

    24. Idebenone [inn:jan]

    25. Dsstox_cid_20678

    26. Dsstox_rid_79536

    27. Dsstox_gsid_40678

    28. Idebenonum [latin]

    29. Idebenona [spanish]

    30. 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone

    31. 2,3-dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4-benzoquinone

    32. Smr000466364

    33. Cas-58186-27-9

    34. Sr-01000759378

    35. Unii-hb6pn45w4j

    36. Cerestabon

    37. Catena

    38. Mnesis

    39. Avan

    40. Idebenone- Bio-x

    41. Raxone (tn)

    42. 1189907-75-2

    43. Idebenone [inn]

    44. Idebenone [jan]

    45. Idebenone [mi]

    46. Idebenone [usan]

    47. Idebenone [mart.]

    48. Idebenone [who-dd]

    49. Snt-mc17

    50. Schembl28320

    51. Idebenone [ema Epar]

    52. Idebenone (jan/usan/inn)

    53. Mls000759487

    54. Mls001032035

    55. Mls001424002

    56. Mls006011882

    57. Idebenone, Analytical Standard

    58. Chembl252556

    59. Qsa-10

    60. Dtxsid0040678

    61. Idebenone, >=98% (hplc)

    62. Fr114

    63. Hms2051o06

    64. Hms2089d08

    65. Hms3393o06

    66. Hms3656k22

    67. Hms3713a10

    68. Hms3884b12

    69. Pharmakon1600-01505755

    70. Albb-027258

    71. Bcp09116

    72. Hy-n0303

    73. Str09227

    74. Zinc1542890

    75. Tox21_111864

    76. Bbl025842

    77. Bdbm50505498

    78. Nsc759228

    79. S2605

    80. Stk801942

    81. Hydroxydecyl Ubiquinone [inci]

    82. 2,5-cyclohexadiene-1,4-dione, 5,6-dimethoxy-2-(10-hydroxydecyl)-3-methyl-

    83. Akos005622577

    84. Tox21_111864_1

    85. Ac-4337

    86. Ccg-100846

    87. Ks-5193

    88. Nc00096

    89. Nsc 759228

    90. Sb19130

    91. Ncgc00160514-02

    92. Ncgc00160514-03

    93. Bi164565

    94. Sy051193

    95. Sbi-0207024.p001

    96. Db-053168

    97. Ft-0617205

    98. I0848

    99. Sw219495-1

    100. D01750

    101. H10427

    102. Ab00639997-04

    103. Ab00639997-06

    104. Ab00639997_07

    105. Ab00639997_08

    106. 186i279

    107. A-68500

    108. Q4197874

    109. Sr-01000759378-4

    110. Sr-01000759378-5

    111. Sr-01000759378-6

    112. Brd-k37516142-001-01-4

    113. 2,3-dimethoxy-6-(10-hydroxydecyl)-5-methylbenzoquinone

    114. 2,3-dimethoxy-6-(10-hydroxydecyl)-5-methyl-1,4benzoquinone

    115. 2-(10-hydroxydecyl)-6-methoxy-3-methyl-5-(trideuteriomethoxy)cyclohexa-2,5-diene-1,4-dione

    2.4 Create Date
    2005-03-25
    3 Chemical and Physical Properties
    Molecular Weight 338.4 g/mol
    Molecular Formula C19H30O5
    XLogP34.3
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count5
    Rotatable Bond Count12
    Exact Mass338.20932405 g/mol
    Monoisotopic Mass338.20932405 g/mol
    Topological Polar Surface Area72.8 Ų
    Heavy Atom Count24
    Formal Charge0
    Complexity502
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Indication

    Raxone is indicated for the treatment of visual impairment in adolescent and adult patients with Lebers Hereditary Optic Neuropathy (LHON).

    Treatment of Friedreichs Ataxia

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Antioxidants

    Naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues. (See all compounds classified as Antioxidants.)

    5.2 ATC Code

    N06BX13

    N06BX13

    N06BX13

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    N - Nervous system

    N06 - Psychoanaleptics

    N06B - Psychostimulants, agents used for adhd and nootropics

    N06BX - Other psychostimulants and nootropics

    N06BX13 - Idebenone