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2D Structure
Also known as: Iodine-123(1-), Iodide (123i(1-)), Iodide i-123, 69239-56-1, 98qpv8670c, I-123
Molecular Formula
I-
Molecular Weight
122.90559  g/mol
InChI Key
XMBWDFGMSWQBCA-AHCXROLUSA-M
FDA UNII
98QPV8670C

Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123. Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4). Radioactive I-123 in particular is effective for this use as its half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a reduced radiation burden as compared to I-131.
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
iodine-123(1-)
2.1.2 InChI
InChI=1S/HI/h1H/p-1/i1-4
2.1.3 InChI Key
XMBWDFGMSWQBCA-AHCXROLUSA-M
2.1.4 Canonical SMILES
[I-]
2.1.5 Isomeric SMILES
[123I-]
2.2 Other Identifiers
2.2.1 UNII
98QPV8670C
2.3 Synonyms
2.3.1 Depositor-Supplied Synonyms

1. Iodine-123(1-)

2. Iodide (123i(1-))

3. Iodide I-123

4. 69239-56-1

5. 98qpv8670c

6. I-123

7. Iodide-123

8. Unii-98qpv8670c

9. Iodine 123

10. Iodide I-123 Ion

11. Iodide Ion I 123

12. Iodide, I-123

13. Iodide Ion (123 I)

14. Dtxsid40988959

15. Db09420

16. 123i-

17. Q3801335

2.4 Create Date
2005-08-08
3 Chemical and Physical Properties
Molecular Weight 122.90559 g/mol
Molecular Formula I-
XLogP30.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass122.90559 g/mol
Monoisotopic Mass122.90559 g/mol
Topological Polar Surface Area0 Ų
Heavy Atom Count1
Formal Charge-1
Complexity0
Isotope Atom Count1
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Drug Indication

Administration of Sodium Iodide I 123 Capsules is indicated as a diagnostic procedure to be used in evaluating thyroid function and/or morphology.


FDA Label


5 Pharmacology and Biochemistry
5.1 Biological Half-Life

Iodine-123 decays by electron capture with a physical half-life of 13.2 hours


5.2 Mechanism of Action

Sodium Iodide I-123 is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123. Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4).