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    Iophendylate

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Ethyl 10-(4-iodophenyl)undecanoate, 99-79-6, Iofendylatum, Ethyl 10-(p-iodophenyl)undecylate, Ethyl 10-(p-iodophenyl)hendecanoate, 6v3i57k9ul
    Molecular Formula
    C19H29IO2
    Molecular Weight
    416.3  g/mol
    InChI Key
    LAYLQVBQIBQVLL-UHFFFAOYSA-N
    FDA UNII
    6V3I57K9UL
    An inert iodine-containing agent which is opaque to X-RAYS. It is used mainly for BRAIN and SPINAL CORD visualization.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    ethyl 10-(4-iodophenyl)undecanoate
    2.1.2 InChI
    InChI=1S/C19H29IO2/c1-3-22-19(21)11-9-7-5-4-6-8-10-16(2)17-12-14-18(20)15-13-17/h12-16H,3-11H2,1-2H3
    2.1.3 InChI Key
    LAYLQVBQIBQVLL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCOC(=O)CCCCCCCCC(C)C1=CC=C(C=C1)I
    2.2 Other Identifiers
    2.2.1 UNII
    6V3I57K9UL
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Ethiodan

    2. Iodophendylate

    3. Ioglunide

    4. Iophendylate

    5. Isophendylate

    6. Maiodil

    7. Myodil

    8. Panthopaque

    9. Pantopaque

    2.3.2 Depositor-Supplied Synonyms

    1. Ethyl 10-(4-iodophenyl)undecanoate

    2. 99-79-6

    3. Iofendylatum

    4. Ethyl 10-(p-iodophenyl)undecylate

    5. Ethyl 10-(p-iodophenyl)hendecanoate

    6. 6v3i57k9ul

    7. Jofendylatum

    8. Iophendylate, P-

    9. Ethiodan

    10. Mulsopaque

    11. Neurotrast

    12. Myodil

    13. Myodyl

    14. Mulsopaque; Myodil; Myodyl; Neurotrast; Pantopaque

    15. Iofendilato

    16. P-iophendylate

    17. Iofendylatum [inn-latin]

    18. Iofendilato [inn-spanish]

    19. Hsdb 3346

    20. Ethyl 10-(p-iodophenyl)undecanoate

    21. Iofendylate [inn:ban]

    22. Einecs 202-787-8

    23. Brn 2661373

    24. Unii-6v3i57k9ul

    25. Iophendilate

    26. Undecanoic Acid, 10-(p-iodophenyl)-, Ethyl Ester

    27. Jofendylate

    28. Benzenedecanoic Acid, 4-iodo-iota-methyl-, Ethyl Ester

    29. Iophendylate [mi]

    30. Chembl951

    31. 3-09-00-02627 (beilstein Handbook Reference)

    32. Schembl492663

    33. Dtxsid2052869

    34. Ethyl10-(4-iodophenyl)undecanoate

    35. Hy-a0223

    36. Akos005267217

    37. Cs-0017569

    38. Ft-0682962

    39. Q3801357

    40. W-100019

    41. Benzenedecanoic Acid, 4-iodo-.iota.-methyl-, Ethyl Ester

    2.4 Create Date
    2005-08-08
    3 Chemical and Physical Properties
    Molecular Weight 416.3 g/mol
    Molecular Formula C19H29IO2
    XLogP37
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count12
    Exact Mass416.12123 g/mol
    Monoisotopic Mass416.12123 g/mol
    Topological Polar Surface Area26.3 Ų
    Heavy Atom Count22
    Formal Charge0
    Complexity285
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Therapeutic Uses

    Contrast Media

    National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

    IT IS ABSORBABLE, IODIZED FATTY ACID COMPD OF LOW VISCOSITY DESIGNED ESPECIALLY FOR MYELOGRAPHY. ... IT IS EQUALLY USEFUL FOR VISUALIZATION OF ALL REGIONS OF SPINAL CORD, ALTHOUGH THIS MAY BE TECHNICALLY MORE DIFFICULT IN CERVICAL & THORACIC REGIONS. ... IOPHENDYLATE ALSO IS USED IN EMULSIFIED AQUEOUS FORM AS CONTRAST MEDIUM FOR VISUALIZATION OF BILIARY TREE, SINUS TRACTS, & CERTAIN BODY CAVITIES.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 802

    IT IS COMMONLY USED FOR VISUALIZATION OF TUMORS OR HERNIATION OF INTERVERTEBRAL DISC OR OTHER LESIONS COMPRESSING SPINAL CORD.

    Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1215

    VET: TO OUTLINE SALIVARY GLANDS, DRAINING SINUSES, OR FISTULAS; IT MAY BE SAFE (1-3 ML) IN SPINAL VENTRICULOGRAPHY OF DOGS.

    Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 285

    DOSE- USUAL, MYELOGRAPHY, INTRATHECAL OR BY SPECIAL INJECTION

    Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1215

    4.2 Drug Warning

    THIS AGENT SHOULD NOT BE USED INTRAVASCULARLY. ... AGENT SHOULD NOT BE USED WHEN LUMBAR PUNCTURE IS CONTRAINDICATED; &, TO AVOID SUBDURAL & EXTRA-ARACHNOID EXTRAVASATION, IT SHOULD NOT BE EMPLOYED WITHIN 10 DAYS OF PREVIOUS LUMBAR PUNCTURE.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 802

    ...PERSISTENT LEVELS IN BODY INTERFERE WITH TRACER STUDIES WITH RADIOACTIVE IODINE.

    Osol, A. (ed.). Remington's Pharmaceutical Sciences. 16th ed. Easton, Pennsylvania: Mack Publishing Co., 1980., p. 1215

    WHEN BULK OF MATERIAL IS REMOVED...INCIDENCE OF SIDE REACTIONS IS LOW.

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 802

    IN GENERAL, IODINATED CONTRAST MEDIA SHOULD BE ADMINISTERED WITH CAUTION IN PATIENTS WITH HEPATIC OR RENAL DYSFUNCTION. ... THE INJECTION OF IODIZED FATTY ACIDS IS ESSENTIALLY A SURGICAL PROCEDURE THAT INVOLVES RISK. THE FOLLOWING CAUTIONS SHOULD BE BORNE IN MIND. PREPARATIONS THAT HAVE AGED & DARKENED BEYOND THE ORIGINAL COLOR SHOULD NOT BE USED. ... THE COMPOUNDS SHOULD NOT BE ADMINISTERED TO INDIVIDUALS WITH HISTORY OF SENSITIVITY TO IODIDES. /IODINATED CONTRAST MEDIA/

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 803

    For more Drug Warnings (Complete) data for IOPHENDYLATE (6 total), please visit the HSDB record page.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Contrast Media

    Substances used to allow enhanced visualization of tissues. (See all compounds classified as Contrast Media.)

    5.2 ATC Code

    V - Various

    V08 - Contrast media

    V08A - X-ray contrast media, iodinated

    V08AD - Non-watersoluble x-ray contrast media

    V08AD04 - Iofendylate

    5.3 Absorption, Distribution and Excretion

    WHEN EXAM IS COMPLETED, COMPD SHOULD BE REMOVED BY ASPIRATION. WHEN BULK OF MATERIAL IS REMOVED, REMAINDER IS ABSORBED WITHIN FEW MONTHS...

    Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 802