1. 2 Propanol
2. 2-propanol
3. Alcohol, Isopropyl
4. Alcohol, Rubbing
5. Isopropanol
6. Rubbing Alcohol
1. Isopropanol
2. 2-propanol
3. Propan-2-ol
4. 67-63-0
5. 2-hydroxypropane
6. Alkolave
7. Avantine
8. Hartosol
9. Dimethylcarbinol
10. Sec-propyl Alcohol
11. I-propanol
12. Petrohol
13. Takineocol
14. Alcojel
15. Avantin
16. 1-methylethanol
17. 2-propyl Alcohol
18. Alcolo
19. Isohol
20. Lavacol
21. Lutosol
22. Propol
23. Alcosolve 2
24. 1-methylethyl Alcohol
25. Imsol A
26. Arquad Dmcb
27. Alcosolve
28. Spectrar
29. I-propylalkohol
30. N-propan-2-ol
31. Combi-schutz
32. I-propyl Alcohol
33. Isopropyl Alcohol, Rubbing
34. Iso-propanol
35. Iso-propylalkohol
36. Alcool Isopropilico
37. Visco 1152
38. Alcool Isopropylique
39. Sterisol Hand Disinfectant
40. I-propanol [german]
41. Sec-propanol
42. Fema No. 2929
43. I-propylalkohol [german]
44. Iso-propyl Alcohol
45. Iso-propylalkohol [german]
46. Alcool Isopropilico [italian]
47. Alcool Isopropylique [french]
48. Iso-propylalcohol
49. Alcohol,isopropyl
50. Propanol-2
51. Isopropyl Alcohol [usp]
52. Mfcd00011674
53. Nsc-135801
54. Chebi:17824
55. Nd2m416302
56. 2-propanol, Anhydrous
57. Ncgc00090917-01
58. Rubbing Alcohol
59. Dsstox_cid_762
60. Isopropyl Alcohol (usp)
61. Iproh
62. Dsstox_rid_75777
63. Dsstox_gsid_20762
64. 2-propanol, Usp, 99.0%
65. Caswell No. 507
66. Isopropylalcohol
67. Isopropyl Alcohol(2-d)
68. Fema Number 2929
69. 2-propanol, Acs Reagent, >=99.5%
70. Cas-67-63-0
71. Alcohol, Isopropyl
72. Ccris 2308
73. Hsdb 116
74. Einecs 200-661-7
75. Un1219
76. Isopropyl Alcohol(1,1,1,3,3,3-d6)
77. Nsc 135801
78. Brn 0635639
79. Isopropyl Alcohol(1,1,1,2,3,3,3-d7)
80. Isoproylalcohol
81. Virahol
82. I-propylalcohol
83. Lavaco
84. Isopropylalkohol
85. 2propanol
86. 2-propylalcohol
87. Isopropy Alcohol
88. Isoproyl Alcohol
89. Ai3-01636
90. 2-propanolum
91. Isopropyl-alcohol
92. Propane-2ol
93. Propan-2ol
94. Unii-nd2m416302
95. 2-propano
96. Isopropryl Alcohol
97. Propane-2-ol
98. 2 -propanol
99. 2- Propanol
100. Propan 2-ol
101. Iso-proh
102. Isopropyl Alcohol
103. I-proh
104. (propan-2-ol)
105. Isopro (tn)
106. Recovered Isopropanol
107. Tissue Dry Dehydrant
108. Zuragard
109. Isopropyl Alcohol C+
110. Hibistat (salt/mix)
111. I-pr-oh
112. Propane, 2-hydroxy-
113. 2-propanol, Ph Eur
114. Iso-c3h7oh
115. Isopropanol (jp17)
116. Isopropanol (recovered)
117. Isopropanol Acs Reagent
118. 2-propanol, Gc Grade
119. 2-propanol, For Hplc
120. Isopropanol [jan]
121. Isopropyl Alcohol - Gmp
122. 2-propanol, Acs Reagent
123. 2-propanol, Hplc Grade
124. Chembl582
125. Isopropyl Alcohol Hplc/uv
126. 2-propanol, 99.5%
127. Ec 200-661-7
128. Ips 1
129. Isopropanol, 70% In Water
130. Isopropanol, 70% In H2o
131. Isopropanol [who-dd]
132. 4-01-00-01461 (beilstein Handbook Reference)
133. Isopropyl Alcohol (manufacture Strong-acid Process)
134. 2-propanol [usp-rs]
135. 2-propanol [who-ip]
136. Isopropanol, Isopropyl Alcohol
137. Isopropyl Alcohol [ii]
138. Isopropyl Alcohol [mi]
139. Isopropanol, 99.5% Anhydrous
140. Wln: Qy1&1
141. 2-propanol, Analytical Standard
142. Isopropanol Or Isopropyl Alcohol
143. Isopropyl Alcohol [fcc]
144. 2-propanol, Lr, >=99%
145. Dtxsid7020762
146. Isopropyl Alcohol [fhfi]
147. Isopropyl Alcohol [hsdb]
148. Isopropyl Alcohol [iarc]
149. Isopropyl Alcohol [inci]
150. Bdbm36154
151. Alcohol,isopropyl [vandf]
152. Isopropyl Alcohol (manufacturing-strong Acid Process Only)
153. Isopropyl Alcohol [vandf]
154. 2-propanol, Anhydrous, 99.5%
155. Isopropyl Alcohol [mart.]
156. Zinc901159
157. 2-propanol, Ar, >=99.5%
158. Amy11029
159. Str00089
160. 2-propanol, 99.9%, Pra Grade
161. 2-propanol, For Hplc, 99.5%
162. 2-propanol, For Hplc, 99.9%
163. 2-propanol, Technical Grade, 95%
164. Isopropyl Alcohol Reagent Grade Acs
165. Tox21_111039
166. Tox21_202475
167. 2-propanol, 99.5%, Hplc Grade
168. 2-propanol, Spectrophotometric Grade
169. 2-propanolum [who-ip Latin]
170. Nsc135801
171. 2-propanol, Histological Grade, 99%
172. Akos000121012
173. 2-propanol, For Hplc, >=99.8%
174. Db02325
175. Isopropyl Alcohol (isopropanol)
176. Isopropyl Alcohol [orange Book]
177. Un 1219
178. Isopropyl Alcohol [ep Monograph]
179. 2-propanol 1000 Microg/ml In Methanol
180. Acetone Impurity B [ep Impurity]
181. Isopropyl Alcohol [usp Monograph]
182. Ncgc00260024-01
183. 2-propanol, 99.95% (lc-ms Grade)
184. 2-propanol, Uv Hplc Gradient, 99.8%
185. Isopropyl Alcohol (only Persons Who Manufacture By The Strong Acid Process Are Subject, Supplier Notification Not Required)
186. Isopropyl Alcohol, Natural, >=98%, Fg
187. Phenolphthalein Solution, Alcoholic 0.5%
188. 2-propanol 100 Microg/ml In Acetonitrile
189. Duraprep Component Isopropyl Alcohol
190. Isopropyl Alcohol, >=99.7%, Fcc, Fg
191. Soluprep Component Isopropyl Alcohol
192. 2-propanol, Saj First Grade, >=99.0%
193. 2-propanol, Jis Special Grade, >=99.5%
194. 2-propanol, Laboratory Reagent, >=99.5%
195. 2-propanol, Meets Usp Testing Specifications
196. Chloraprep Component Isopropyl Alcohol
197. Ft-0613371
198. Ft-0670483
199. I0163
200. I0164
201. I0277
202. Isopropanol, 99.5% Anhydrous, 50 Ppm Water
203. Isopropyl Alcohol Component Of Duraprep
204. Isopropyl Alcohol Component Of Soluprep
205. C01845
206. D00137
207. Q16392
208. Isopropyl Alcohol Component Of Chloraprep
209. Sr-01000944474
210. J-510285
211. Sr-01000944474-1
212. 2-propanol, Acs Spectrophotometric Grade, >=99.5%
213. 2-propanol, P.a., Acs Reagent, Reag. Iso, 99.8%
214. 2-propanol, Reag. Iso, Uv Hplc Spectroscopic, 99.7%
215. 2-propanol, Bioreagent, For Molecular Biology, >=99.5%
216. 2-propanol, Electronic Grade, 99.999% Trace Metals Basis
217. 2-propanol, Puriss. P.a., Acs Reagent, >=99.8% (gc)
218. 2-propanol, Vetec(tm) Reagent Grade, Anhydrous, >=99.5%
219. 2-propanol, Bioultra, For Molecular Biology, >=99.5% (gc)
220. Isopropanol Or Isopropyl Alcohol [un1219] [flammable Liquid]
221. Isopropyl Alcohol, Europepharmacopoeia (ep) Reference Standard
222. Isopropyl Alcohol, Meets Ep, Bp, Usp Testing Specifications
223. 2-propanol, >=99.7%, Suitable For Absorption Spectrum Analysis
224. 2-propanol, Semiconductor Grade Puranal(tm) (honeywell 17829)
225. 2-propanol, United States Pharmacopeia (usp) Reference Standard
226. 2-propanol, >=99.7%, For Residue Analysis, Suitable For 1000 Per Jis
227. 2-propanol, Hplc Plus, For Hplc, Gc, And Residue Analysis, 99.9%
228. 2-propanol, Pharmaceutical Secondary Standard; Certified Reference Material
229. 2-propanol, Semiconductor Grade Mos Puranal(tm) (honeywell 17930)
230. 2-propanol, Semiconductor Grade Slsi Puranal(tm) (honeywell 17030)
231. 2-propanol, Semiconductor Grade Ulsi Puranal(tm) (honeywell 17022)
232. 2-propanol, Semiconductor Grade Vlsi Puranal(tm) (honeywell 17604)
233. 2-propanol, Hplc Plus, For Hplc, Gc, And Residue Analysis, 99.9%, Poly Coated Bottles
234. 2-propanol, Puriss. P.a., Acs Reagent, Reag. Iso, Reag. Ph. Eur., >=99.8% (gc)
235. 2-propanol, Puriss., Meets Analytical Specification Of Ph. Eur., Bp, Usp, >=99.5% (gc)
236. 8003-15-4
| Molecular Weight | 60.10 g/mol |
|---|---|
| Molecular Formula | C3H8O |
| XLogP3 | 0.3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 0 |
| Exact Mass | 60.057514874 g/mol |
| Monoisotopic Mass | 60.057514874 g/mol |
| Topological Polar Surface Area | 20.2 Ų |
| Heavy Atom Count | 4 |
| Formal Charge | 0 |
| Complexity | 10.8 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently Bonded Unit Count | 1 |
Anti-Infective Agents, Local; Solvents
National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)
MEDICATION (VET): Antiseptic, rubefacient
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 901
ALCOHOLS ARE APPLIED TO REDUCE LOCAL BACTERIAL FLORA PRIOR TO PENETRATION WITH NEEDLES OR OTHER SHARP INSTRUMENTS AND AS A PREOPERATIVE WASH. ... ISOPROPYL ALCOHOL HAS SLIGHTLY GREATER BACTERIAL ACTIVITY THAN ETHYL ALCOHOL DUE TO ITS GREATER DEPRESSION OF SURFACE TENSION. IT RAPIDLY KILLS VEGETATIVE FORMS OF MOST BACTERIA WHEN USED FULL STRENGTH OR AS 70% AQ SOLN.
American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986., p. 1523
EXPTL USE: HEPATITIS B VIRUS IN DRIED HUMAN PLASMA WAS EXPOSED FOR 10 MIN AT 20 C TO 70% ISOPROPANOL, A CHEMICAL DISINFECTANT HAVING INTERMEDIATE ACTIVITY LEVEL. ONE CHIMPANZEE RECEIVED TREATED MATERIAL IV, & DID NOT SHOW SIGNS OF INFECTION AFTER POST-INOCULATION PERIOD OF 9 MONTHS.
PMID:6630443 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC270849 BOND WW ET AL; J CLIN MICROBIOL 18 (3): 535 (1983)
Antiseptic
O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 901
ACCORDING TO CLINICAL EXPERIENCE ISOPROPYL ALCOHOL IS MORE TOXIC THAN ETHYL ALCOHOL AND LESS TOXIC THAN METHYL ALCOHOL. ... ITS ACUTE POTENCY AS CENTRAL NERVOUS DEPRESSANT IS ABOUT TWICE THAT OF ETHANOL. PROBABLE LETHAL ORAL DOSE FOR ADULT IS 8 OZ (240 ML), BUT AS LITTLE AS 20 ML IN WATER CAN PRODUCE SYMPTOMS.
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-271
A single lethal dose for a human is about 250 mL, although as little as 100 mL can be fatal.
Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 2149
Solvents
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant and Hackh's Chemical Dictionary, 5th ed) (See all compounds classified as Solvents.)
D - Dermatologicals
D08 - Antiseptics and disinfectants
D08A - Antiseptics and disinfectants
D08AX - Other antiseptics and disinfectants
D08AX05 - Isopropanol
DISTRIBUTION OF ISOPROPYL ALC ... IN TISSUES OF DOGS 4 HR AFTER ORAL ADMIN OF 90 ML OF ISOPROPYL ALCOHOL WAS DETERMINED ... USING DOGS THAT HAD BEEN GIVEN PROGRESSIVELY INCR AMT OF THE ALCOHOL FOR THE PREVIOUS 59 DAYS. ... CONCENTRATIONS OF ISOPROPYL ALCOHOL FOUND IN THE TISSUES AND BODY FLUIDS DECREASED IN THE FOLLOWING ORDER: BRAIN, URINE, HEART, KIDNEY, AND BLOOD.
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4566
Intestinal uptake of isopropanol is rapid; 80% of an oral dose is absorbed within 30 min. Complete absorption occurs within 2 hr ... . Skin absorption is probably relatively small but contributes to toxicity with prolonged contact. ... Isopropanol distribution in body water with an apparent vol of distribution of 0.6-0.7 L/kg. Two hr are required for complete tissue distribution. ... The kidney excretes 20-50% of an absorbed dose unchanged. Alcohol dehydrogenase oxidizes most isopropanol to acetone, which the lung or kidney slowly eliminates. ... Clinically insignificant excretion occurs into the stomach and saliva.
Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 798
ABOUT 47% OF ORAL DOSE OF 720 MG ... WAS EXHALED UNCHANGED OVER 3 HR; LESS THAN 3% ... ELIMINATED IN BREATH AS ACETONE ...
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V15 235 (1977)
DISAPPEARANCE RATE OF ISOPROPYL ALC IN BLOOD IS HALF THAT OF ETHANOL BUT 5 TIMES THAT OF METHANOL.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V15 234 (1977)
For more Absorption, Distribution and Excretion (Complete) data for ISOPROPANOL (12 total), please visit the HSDB record page.
ISOPROPANOL IS OXIDIZED, MORE SLOWLY THAN ETHANOL OR N-PROPANOL, TO ACETONE, & SOME 10% OF DOSE IS EXCRETED BY RABBITS AS GLUCURONIDE CONJUGATE OF ISOPROPANOL.
Parke, D. V. The Biochemistry of Foreign Compounds. Oxford: Pergamon Press, 1968., p. 214
METABOLISM OF ETHANOL, PROPANOL, ISOPROPANOL, BUTANOL, ISOBUTANOL, SEC-BUTANOL, & TERT-BUTANOL WAS STUDIED AFTER ORAL ADMIN IN RABBITS. BLOOD PH WAS ON THE ACID SIDE WITH PROPANOL, BUTANOL, & ISOBUTANOL, AND ON THE ALKALINE SIDE WITH ISOPROPANOL & SEC-BUTANOL, BUT NO CHANGE WAS OBSERVED WITH ETHANOL & TERT-BUTANOL. BUTANOL & ISOBUTANOL HAD THE LOWEST RATE OF URINARY EXCRETION. ACETALDEHYDE AND ACETIC ACID WERE DETECTED AS THE URINARY METABOLITES OF ETHANOL AND PROPANOL, WHEREAS ISOBUTYRALDEHYDE & ISOVALERIC ACID WERE THE METABOLITES OF ISOBUTANOL.
SAITO M; NICHIDAI IGAKU ZASSHI 34 (8-9): 569-85 (1975)
Alcohol dehydrogenase oxidizes most isopropanol to acetone, which the lung or kidney slowly eliminates. Acetone probably is further metabolized to acetate, formate, and finally carbon dioxide.
Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 798
Liver alcohol dehydrogonase (ADH) is the major enzyme involved in the oxidation of 2-propanol. ADH oxidizes most 2-propanol to acetone. Acetone then is eliminated from the kidney & expired air. It is estimated that 70-90% of ingested 2-propanol is metabolized to acetone. Acetone is probably further metabolized to acetate, formate & finally carbon dioxide. Conversion of acetone to acetic acid & formic acid may cause acidosis. Metabolism of 2-propanol leads to a shift in NAD/NADH ratio which may cause hypoglycemia.
Snyder, R. (ed.). Ethel Browning's Toxicity and Metabolism of Industrial Solvents. Second Edition. Volume 3 Alcohols and Esters. New York, NY: Elsevier, 1992., p. 33
The metabolism of isopropanol is via oxidation by aldehyde dehydrogenase (ADH) to acetone. In common with other alpha-substituted (secondary) alcohols, isopropanol is a relatively poor substrate for ADH. The primary metabolite, acetone, is eliminated in the expired air and in the urine and also undergoes further oxidation to acetate, formate and ultimately CO2.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V71 1030 (1999)
2-propanol has known human metabolites that include (2S,3S,4S,5R)-3,4,5-Trihydroxy-6-propan-2-yloxyoxane-2-carboxylic acid.
S73 | METXBIODB | Metabolite Reaction Database from BioTransformer | DOI:10.5281/zenodo.4056560
Whole body: 6 hours; whole body for acetone, a metabolite: 22 hours; [TDR, p. 781]
TDR - Ryan RP, Terry CE, Leffingwell SS (eds). Toxicology Desk Reference: The Toxic Exposure and Medical Monitoring Index, 5th Ed. Washington DC: Taylor & Francis, 1999., p. 781
... 1 G/KG WAS INJECTED IV OR INTRAPERITONEALLY IN DOGS AND RATS & PLASMA LEVELS OF ISOPROPYL ALCOHOL & ITS METABOLITE, ACETONE, WERE DETERMINED ... AT INTERVALS. THE MAXIMUM CONCN OF ACETONE WAS 12.4 MMOLES 9 HR AFTER INJECTION ... IN DOGS & 12.0 MMOLES 5 HR AFTER INJECTION IN RATS. ... THE HALF TIME FOR THE ELIMINATION OF ISOPROPYL ALCOHOL BY THE DOG & RAT IS 4 & 2 HR, RESPECTIVELY, & OF ACETONE 11 AND 5/HR.
Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 4567
In two intoxicated chronic alcoholics, isopropanol elimination exhibited first order kinetics with a half-life of 2.5-3.2 hr. The elimination half-life of ... acetone was more prolonged.
Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 799
/In/ inhalation of 70% isopropyl alcohol by a neonate ... the isopropyl alcohol elimination half-life was 9.6 hr.
Ellenhorn, M.J., S. Schonwald, G. Ordog, J. Wasserberger. Ellenhorn's Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams and Wilkins, 1997., p. 1148
In adults, the elimination half life ranges from 2.9 to 16.2 hours and this is shorter in alcoholics. Values observed in children poisoned with isopropanol fall within this range.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V71 1030 (1999)
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