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    Kanamycin Sulfate

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    DIGITAL CONTENT

    GLOBAL SALES INFORMATION

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 54Xls

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    2D Structure
    Also known as: Kanamycin a sulfate, Kanamycin monosulfate, 25389-94-0, Kanamycin acid sulfate, Kanamycin a sulphate, Kanamycin (sulfate)
    Molecular Formula
    C18H38N4O15S
    Molecular Weight
    582.6  g/mol
    InChI Key
    OOYGSFOGFJDDHP-KMCOLRRFSA-N
    FDA UNII
    J80EX28SMQ
    Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (2R,3S,4S,5R,6R)-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric acid
    2.1.2 InChI
    InChI=1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
    2.1.3 InChI Key
    OOYGSFOGFJDDHP-KMCOLRRFSA-N
    2.1.4 Canonical SMILES
    C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)O)O)OC3C(C(C(C(O3)CO)O)N)O)N.OS(=O)(=O)O
    2.1.5 Isomeric SMILES
    C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)N)O)N.OS(=O)(=O)O
    2.2 Other Identifiers
    2.2.1 UNII
    J80EX28SMQ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Kanamycin

    2. Kanamycin A

    3. Kantrex

    2.3.2 Depositor-Supplied Synonyms

    1. Kanamycin A Sulfate

    2. Kanamycin Monosulfate

    3. 25389-94-0

    4. Kanamycin Acid Sulfate

    5. Kanamycin A Sulphate

    6. Kanamycin (sulfate)

    7. Ophtalmokalixan

    8. 133-92-6

    9. Kanamycin Monosulphate

    10. 3847-27-6

    11. J80ex28smq

    12. Kanamycin Monosulfate [jan]

    13. Kanamycin A Monosulfate

    14. Chebi:6109

    15. Nsc-757068

    16. (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-diamino-3-[(2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4,5-triol;sulfuric Acid

    17. Dsstox_cid_27524

    18. Dsstox_rid_82394

    19. Dsstox_gsid_47524

    20. Cristalomicina

    21. Kanabristol

    22. Kanamytrex

    23. Otokalixin

    24. Cantrex

    25. Kanacedin

    26. Kanaqua

    27. Kanasig

    28. Kanatrol

    29. Kanescin

    30. Kanicin

    31. Kannasyn

    32. Kantrim

    33. Kano

    34. (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-(((1r,2r,3s,4r,6s)-4,6-diamino-3-(((2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)tetrahydro-2h-pyran-3,4,5-triol Sulfate

    35. Kanamycin Sulfate [jan]

    36. Unii-j80ex28smq

    37. Kanamycin Sulfate [usp:jan]

    38. Mfcd00070253

    39. Kanamycin Sulfate From Streptomyces Kanamyceticus, Animal Component-free

    40. Einecs 223-347-1

    41. Einecs 246-933-9

    42. Kantrex (tn)

    43. Kanamycin, Sulfate (1:1) (salt)

    44. Kanamycin Sulfate (tn)

    45. Kanamycin Sulfate (usp)

    46. Ncgc00016792-01

    47. Kanamycin Sulfate Solution

    48. Kanamycin Sulfate (jp17)

    49. Kanamycin Sulphate (1:1)

    50. Cas-25389-94-0

    51. Chembl1446

    52. Schembl65538

    53. Kanamycin Mono Sulfate

    54. Kanamycin Monosulfate (jp17)

    55. Dtxsid1047524

    56. Hms500b06

    57. Kuc109575ac

    58. Kanamycin A Sulfate [mi]

    59. Kanamycin Sulfate [vandf]

    60. Hms2096o09

    61. Hms3713o09

    62. Kanamycin Sulfate [usp-rs]

    63. Kanamycin Sulfate [who-dd]

    64. D-streptamine, O-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-->6)-o-[6-amino-6-deoxy-alpha-d-glucopyranosyl-(1-->4)]-2-deoxy-, Sulfate (1:1)

    65. Ksc-27-052c

    66. Tox21_110612

    67. Tox21_202817

    68. Hy-16566a

    69. S2315

    70. C18h36n4o11 .h2o4s

    71. Akos025310124

    72. Kanamycin Sulfate [green Book]

    73. Ccg-220394

    74. Cs-1140

    75. Kanamycin Sulfate [orange Book]

    76. Nsc 757068

    77. Kanamycin Sulfate [usp Monograph]

    78. Ncgc00260363-01

    79. Kanamycin Monosulfate, Cell Culture Grade

    80. Kanamycin Sulfate 100 Microg/ml In Water

    81. Kanamycin Monosulfate [ep Monograph]

    82. K0047

    83. C08046

    84. D00866

    85. D03262

    86. 133k926

    87. Q27107073

    88. Kanamycin Sulfate Streptomyces Kanamyceticus, Powder, Gamma-irradiated

    89. Kanamycin Sulfate From Streptomyces Kanamyceticus, Meets Usp Testing Specifications, Powder

    90. Kanamycin Sulfate, Mixture Of Kanamycin A (main Component) And Kanamycin B And C

    91. Kanamycin Sulfate, Pharmaceutical Secondary Standard; Certified Reference Material

    92. (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-((1r,2r,3s,4r,6s)-4,6-diamino-3-((2s,3r,4s,5s,6r)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)-2-hydroxycyclohexyloxy)tetrahydro-2h-pyran-3,4,5-triol Sulfate

    93. (2r,3s,4s,5r,6r)-2-(aminomethyl)-6-[(1r,2r,3s,4r,6s)-4,6-bis(azanyl)-3-[(2s,3r,4s,5s,6r)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-2-oxidanyl-cyclohexyl]oxy-oxane-3,4,5-triol Sulphate

    94. .alpha.-d-glucopyranoside, (1s,2r,3r,4s,6r)-4,6-diamino-3-[(6-amino-6-deoxy-.alpha.-d-glucopyranosyl)oxy]-2-hydroxycyclohexyl 3-amino-3-deoxy-, Sulfate (1:1) (salt)

    95. D-streptamine, O-3-amino-3-deoxy-.alpha.-d-glucopyranosyl(1->6)-o-(6-amino-6-deoxy-.alpha.-d-glucopyranosyl(1->4))-2-deoxy-, Sulfate (1:1) (salt)

    96. D-streptamine, O-3-amino-3-deoxy-.alpha.-d-glucopyranosyl(1->6)-o-(6-amino-6-deoxy-.alpha.-d-glucopyranosyl(1->4))-2-deoxy-, Sulphate (1:1) (salt)

    97. D-streptamine, O-3-amino-3-deoxy-alpha-d-glucopyranosyl(1->6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl(1->4))-2-deoxy-, Sulfate (1:1) (salt)

    98. D-streptamine, O-3-amino-3-deoxy-alpha-d-glucopyranosyl(1-6)-o-(6-amino-6-deoxy-alpha-d-glucopyranosyl(1-4))-2-deoxy-, Sulfate (1:1) (salt)

    99. Kanamycin Sulfate From Streptomyces Kanamyceticus, Powder, Bioreagent, Suitable For Cell Culture, Suitable For Plant Cell Culture

    100. O-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1->6)-o-[6-amino-6-deoxy-alpha-d-glucopyranosyl-(1->4)]-2-deoxy-d-streptamine Monosulfate

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 582.6 g/mol
    Molecular Formula C18H38N4O15S
    Hydrogen Bond Donor Count13
    Hydrogen Bond Acceptor Count19
    Rotatable Bond Count6
    Exact Mass582.20543769 g/mol
    Monoisotopic Mass582.20543769 g/mol
    Topological Polar Surface Area366 Ų
    Heavy Atom Count38
    Formal Charge0
    Complexity720
    Isotope Atom Count0
    Defined Atom Stereocenter Count15
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameKanamycin sulfate
    Active IngredientKanamycin sulfate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 1gm base/3ml; eq 500mg base/2ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    2 of 2  
    Drug NameKanamycin sulfate
    Active IngredientKanamycin sulfate
    Dosage FormInjectable
    RouteInjection
    Strengtheq 1gm base/3ml; eq 500mg base/2ml
    Market StatusPrescription
    CompanyFresenius Kabi Usa

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Bacterial Agents

    Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)

    Protein Synthesis Inhibitors

    Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins. (See all compounds classified as Protein Synthesis Inhibitors.)