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    Lamivudine, Zidovudine Drug Combination

    FINISHED DOSAGE FORMULATIONS

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    2D Structure
    Also known as: Lamivudine + zidovudine, 165456-81-5, 4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione, Lamivudine; zidovudine, Zidovudine / lamivudine, Lamivudine / zidovudine
    Molecular Formula
    C18H24N8O7S
    Molecular Weight
    496.5  g/mol
    InChI Key
    LHCOVOKZWQYODM-CPEOKENHSA-N
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
    2.1.2 InChI
    InChI=1S/C10H13N5O4.C8H11N3O3S/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8;9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h3,6-8,16H,2,4H2,1H3,(H,12,17,18);1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+,8+;6-,7+/m00/s1
    2.1.3 InChI Key
    LHCOVOKZWQYODM-CPEOKENHSA-N
    2.1.4 Canonical SMILES
    CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-].C1C(OC(S1)CO)N2C=CC(=NC2=O)N
    2.1.5 Isomeric SMILES
    CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)N=[N+]=[N-].C1[C@H](O[C@H](S1)CO)N2C=CC(=NC2=O)N
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Combivir

    2. Lamivudine, Zidovudine Drug Combination

    2.2.2 Depositor-Supplied Synonyms

    1. Lamivudine + Zidovudine

    2. 165456-81-5

    3. 4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

    4. Lamivudine; Zidovudine

    5. Zidovudine / Lamivudine

    6. Lamivudine / Zidovudine

    7. Lamivudine, Zidovudine Drug Combination

    8. 3tc / Zdv

    9. Combivir(tm)

    10. Lamivudine Mixture With Zidovudine

    11. Zidovudine Mixture With Lamivudine

    12. Epivir & Retrovir

    13. 4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one; 1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione

    14. Mixture Of Lamivudine And Zidovudine

    15. Lamivudine & Zidovudine

    16. 3tc & Zdv

    17. Azt & 3tc & Sst

    18. (-)-3tc & Azt

    19. .beta.-l-(-)-2',3'-dideoxy-3'-thiacytidine & 3'-azido-3'-deoxythymidine

    20. .beta.-l-(-)-2',3'-dideoxy-3'-thiacytidine & 3'-azido-3'-deoxythymidine & Sho-saiko-to

    21. Thymidine, 3'-azido-3'-deoxy-, Mixt. With 4-amino-1-((2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1h)-pyrimidinone

    2.3 Create Date
    2005-08-01
    3 Chemical and Physical Properties
    Molecular Weight 496.5 g/mol
    Molecular Formula C18H24N8O7S
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count5
    Exact Mass496.14886631 g/mol
    Monoisotopic Mass496.14886631 g/mol
    Topological Polar Surface Area207 Ų
    Heavy Atom Count34
    Formal Charge0
    Complexity815
    Isotope Atom Count0
    Defined Atom Stereocenter Count5
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NameLamivudine and zidovudine
    Drug LabelCOMBIVIR: COMBIVIR Tablets are combination tablets containing lamivudine and zidovudine. Lamivudine (EPIVIR) and zidovudine (RETROVIR, azidothymidine, AZT, or ZDV) are synthetic nucleoside analogues with activity against HIV-1.COMBIVIR Tablets are fo...
    Active IngredientLamivudine and zidovudine; Lamivudine; zidovudine
    Dosage FormTablet
    Routeoral; Oral
    Strength150mg; 300mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Hetero Labs Ltd V; Aurobindo Pharma; Lupin; Teva Pharms; Strides Arcolab

    2 of 4  
    Drug NameLamivudine; zidovudine
    Active Ingredientefavirenz; Lamivudine; zidovudine
    Dosage FormTablet, for suspension; Tablet
    Routeoral; oral suspension
    Strength60mg; 30mg; 150mg; 600mg; 300mg
    Market StatusTentative Approval
    CompanyMacleods Pharma; Hetero Drugs; Aurobindo; Mylan Labs; Aurobindo Pharma; Cipla; Pharmacare; Matrix Labs; Emcure Pharma

    3 of 4  
    Drug NameLamivudine and zidovudine
    Drug LabelCOMBIVIR: COMBIVIR Tablets are combination tablets containing lamivudine and zidovudine. Lamivudine (EPIVIR) and zidovudine (RETROVIR, azidothymidine, AZT, or ZDV) are synthetic nucleoside analogues with activity against HIV-1.COMBIVIR Tablets are fo...
    Active IngredientLamivudine and zidovudine; Lamivudine; zidovudine
    Dosage FormTablet
    Routeoral; Oral
    Strength150mg; 300mg
    Market StatusTentative Approval; Prescription
    CompanyMylan Pharms; Hetero Labs Ltd V; Aurobindo Pharma; Lupin; Teva Pharms; Strides Arcolab

    4 of 4  
    Drug NameLamivudine; zidovudine
    Active Ingredientefavirenz; Lamivudine; zidovudine
    Dosage FormTablet, for suspension; Tablet
    Routeoral; oral suspension
    Strength60mg; 30mg; 150mg; 600mg; 300mg
    Market StatusTentative Approval
    CompanyMacleods Pharma; Hetero Drugs; Aurobindo; Mylan Labs; Aurobindo Pharma; Cipla; Pharmacare; Matrix Labs; Emcure Pharma

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-HIV Agents

    Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS. (See all compounds classified as Anti-HIV Agents.)

    Reverse Transcriptase Inhibitors

    Inhibitors of reverse transcriptase (RNA-DIRECTED DNA POLYMERASE), an enzyme that synthesizes DNA on an RNA template. (See all compounds classified as Reverse Transcriptase Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Human Immunodeficiency Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]; Nucleoside Analog [EXT]; Nucleoside Reverse Transcriptase Inhibitors [MoA]; Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor [EPC]