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    Lanolin

    ACTIVE PHARMA INGREDIENTS

    FINISHED DOSAGE FORMULATIONS

    MARKET PLACE

    REF. STANDARDS & IMPURITIES

    PharmaCompass
    $ API Ref.Price (USD/KG) : 7Xls

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    2D Structure
    Also known as: Stearyl palmitate, Octadecyl palmitate, Octadecyl hexadecanoate, 2598-99-4, Hexadecanoic acid, octadecyl ester, Palmitic acid stearyl ester
    Molecular Formula
    C34H68O2
    Molecular Weight
    508.9  g/mol
    InChI Key
    BILPUZXRUDPOOF-UHFFFAOYSA-N
    FDA UNII
    214W90O2XZ
    lanolin is a natural product found in Bombax ceiba with data available.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    octadecyl hexadecanoate
    2.1.2 InChI
    InChI=1S/C34H68O2/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-33-36-34(35)32-30-28-26-24-22-20-16-14-12-10-8-6-4-2/h3-33H2,1-2H3
    2.1.3 InChI Key
    BILPUZXRUDPOOF-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC
    2.2 Other Identifiers
    2.2.1 UNII
    214W90O2XZ
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Hexadecanoic Acid Octadecyl Ester

    2. Octadecyl Hexadecanoate

    3. Octadecyl Palmitate

    4. Palmitic Acid Octadecyl Ester

    5. Stearyl Palmitate

    2.3.2 Depositor-Supplied Synonyms

    1. Stearyl Palmitate

    2. Octadecyl Palmitate

    3. Octadecyl Hexadecanoate

    4. 2598-99-4

    5. Hexadecanoic Acid, Octadecyl Ester

    6. Palmitic Acid Stearyl Ester

    7. 100231-75-2

    8. 8006-54-0

    9. Octadecanyl Hexadecanoate

    10. Palmitic Acid, Octadecyl Ester

    11. 214w90o2xz

    12. We(18:0/16:0)

    13. Einecs 220-000-6

    14. Unii-214w90o2xz

    15. Wool Grease

    16. Ai3-30713

    17. Wool Wax

    18. Einecs 309-376-3

    19. Wool Wax;wool Grease

    20. Stearyl Palmitate, >=99%

    21. Schembl33919

    22. Dtxsid0026048

    23. Stearyl Palmitate [inci]

    24. Chebi:84066

    25. Caa59899

    26. Palmitic Acid, Stearyl Ester

    27. Lmfa07010049

    28. Zinc60050365

    29. Akos028115046

    30. Ccg-269767

    31. Db-046811

    32. Ft-0634387

    33. J-016213

    34. Q27157447

    2.4 Create Date
    2005-03-27
    3 Chemical and Physical Properties
    Molecular Weight 508.9 g/mol
    Molecular Formula C34H68O2
    XLogP316.3
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count32
    Exact Mass508.52193141 g/mol
    Monoisotopic Mass508.52193141 g/mol
    Topological Polar Surface Area26.3 Ų
    Heavy Atom Count36
    Formal Charge0
    Complexity406
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Warning

    Since certain individuals are allergic to this substance, it should not be used in ointments intended for use by sensitive persons.

    Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1250

    4.2 Minimum/Potential Fatal Human Dose

    1= PRACTICALLY NONTOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QT FOR 70 KG PERSON (150 LB).

    Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-152

    4.3 Drug Indication

    Used as a skin protectant, and to relieve dryness and irritation of the skin,. Helps prevent and treat diaper dermatitis.

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Lanolin treats cracked, dry, irritated skin and minor burns. It prevents and treats sore nipples during breastfeeding,. Protects chafed skin or minor skin irritations due to various causes,.

    5.2 Mechanism of Action

    Lanolin is an emollient. Emollients soften the skin by forming an occlusive oil film on the stratum corneum layer of the epithelium, thus decreasing the transepidermal water loss.